Personal profile

Research interests

Background

Previously depicted as the ‘dark matter of the genome’, it is becoming clearer that genes encoding long noncoding RNAs (lncRNA) are important players in all aspects of cell biology. LncRNAs are expressed in a tissue specific manner during development, have evolved in complex organisms and, surprisingly, are found in polysomes. What do these lncRNAs do? They bind proteins and regulate their activity (they do other things as well). While there are more than 10,000 different lncRNAs, only ~ 100 lncRNAs have been characterized to date and elucidating the functions these non coding RNAs have evolved to fulfil is our challenge.

Current Projects

1. We are studying lncRNAs that are important in brain cancer, glioblastoma, in general and in particular in glioblastoma cancer stem cells. 2. We are interested in how protein synthesis is regulated in the cells. We aim to learn more about the functions of lncRNAs in basic cell biology processes, in particular in regulation of protein translation. In cells, there is tight regulation of which RNAs will actually be translated. This is observed as specific RNAs partition between polysomal (translated) and non-polysomal (untranslated) fractions in resting and in stimulated conditions. We observed that lncRNA behave in a similar manner to coding mRNAs and we aim to elucidate their contribution to the translational landscape of the cell.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

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Collaborations and top research areas from the last five years

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  • Brillouin gain microscopy

    Shaashoua, R., Kasuker, L., Kishner, M., Levy, T., Rotblat, B., Ben-Zvi, A. & Bilenca, A., 1 Aug 2024, In: Nature Photonics. 18, 8, p. 836-841 6 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    2 Scopus citations
  • Enhancing Mechanical Stimulated Brillouin Scattering Imaging with Physics-Driven Model Selection

    Shaashoua, R., Levy, T., Rotblat, B. & Bilenca, A., 1 Jun 2024, In: Laser and Photonics Reviews. 18, 6, 2301054.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    2 Scopus citations
  • mTORC1 regulates cell survival under glucose starvation through 4EBP1/2-mediated translational reprogramming of fatty acid metabolism

    Levy, T., Voeltzke, K., Hruby, L., Alasad, K., Bas, Z., Snaebjörnsson, M., Marciano, R., Scharov, K., Planque, M., Vriens, K., Christen, S., Funk, C. M., Hassiepen, C., Kahler, A., Heider, B., Picard, D., Lim, J. K. M., Stefanski, A., Bendrin, K. & Vargas-Toscano, A. & 11 others, Kahlert, U. D., Stühler, K., Remke, M., Elkabets, M., Grünewald, T. G. P., Reichert, A. S., Fendt, S. M., Schulze, A., Reifenberger, G., Rotblat, B. & Leprivier, G., 1 Dec 2024, In: Nature Communications. 15, 1, 4083.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    16 Scopus citations
  • Apoptotic cell death in disease—Current understanding of the NCCD 2023

    Vitale, I., Pietrocola, F., Guilbaud, E., Aaronson, S. A., Abrams, J. M., Adam, D., Agostini, M., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., Aqeilan, R. I., Arama, E., Baehrecke, E. H., Balachandran, S., Bano, D., Barlev, N. A., Bartek, J. & Bazan, N. G. & 208 others, Becker, C., Bernassola, F., Bertrand, M. J. M., Bianchi, M. E., Blagosklonny, M. V., Blander, J. M., Blandino, G., Blomgren, K., Borner, C., Bortner, C. D., Bove, P., Boya, P., Brenner, C., Broz, P., Brunner, T., Damgaard, R. B., Calin, G. A., Campanella, M., Candi, E., Carbone, M., Carmona-Gutierrez, D., Cecconi, F., Chan, F. K. M., Chen, G. Q., Chen, Q., Chen, Y. H., Cheng, E. H., Chipuk, J. E., Cidlowski, J. A., Ciechanover, A., Ciliberto, G., Conrad, M., Cubillos-Ruiz, J. R., Czabotar, P. E., D’Angiolella, V., Daugaard, M., Dawson, T. M., Dawson, V. L., De Maria, R., De Strooper, B., Debatin, K. M., Deberardinis, R. J., Degterev, A., Del Sal, G., Deshmukh, M., Di Virgilio, F., Diederich, M., Dixon, S. J., Dynlacht, B. D., El-Deiry, W. S., Elrod, J. W., Engeland, K., Fimia, G. M., Galassi, C., Ganini, C., Garcia-Saez, A. J., Garg, A. D., Garrido, C., Gavathiotis, E., Gerlic, M., Ghosh, S., Green, D. R., Greene, L. A., Gronemeyer, H., Häcker, G., Hajnóczky, G., Hardwick, J. M., Haupt, Y., He, S., Heery, D. M., Hengartner, M. O., Hetz, C., Hildeman, D. A., Ichijo, H., Inoue, S., Jäättelä, M., Janic, A., Joseph, B., Jost, P. J., Kanneganti, T. D., Karin, M., Kashkar, H., Kaufmann, T., Kelly, G. L., Kepp, O., Kimchi, A., Kitsis, R. N., Klionsky, D. J., Kluck, R., Krysko, D. V., Kulms, D., Kumar, S., Lavandero, S., Lavrik, I. N., Lemasters, J. J., Liccardi, G., Linkermann, A., Lipton, S. A., Lockshin, R. A., López-Otín, C., Luedde, T., MacFarlane, M., Madeo, F., Malorni, W., Manic, G., Mantovani, R., Marchi, S., Marine, J. C., Martin, S. J., Martinou, J. C., Mastroberardino, P. G., Medema, J. P., Mehlen, P., Meier, P., Melino, G., Melino, S., Miao, E. A., Moll, U. M., Muñoz-Pinedo, C., Murphy, D. J., Niklison-Chirou, M. V., Novelli, F., Núñez, G., Oberst, A., Ofengeim, D., Opferman, J. T., Oren, M., Pagano, M., Panaretakis, T., Pasparakis, M., Penninger, J. M., Pentimalli, F., Pereira, D. M., Pervaiz, S., Peter, M. E., Pinton, P., Porta, G., Prehn, J. H. M., Puthalakath, H., Rabinovich, G. A., Rajalingam, K., Ravichandran, K. S., Rehm, M., Ricci, J. E., Rizzuto, R., Robinson, N., Rodrigues, C. M. P., Rotblat, B., Rothlin, C. V., Rubinsztein, D. C., Rudel, T., Rufini, A., Ryan, K. M., Sarosiek, K. A., Sawa, A., Sayan, E., Schroder, K., Scorrano, L., Sesti, F., Shao, F., Shi, Y., Sica, G. S., Silke, J., Simon, H. U., Sistigu, A., Stephanou, A., Stockwell, B. R., Strapazzon, F., Strasser, A., Sun, L., Sun, E., Sun, Q., Szabadkai, G., Tait, S. W. G., Tang, D., Tavernarakis, N., Troy, C. M., Turk, B., Urbano, N., Vandenabeele, P., Vanden Berghe, T., Vander Heiden, M. G., Vanderluit, J. L., Verkhratsky, A., Villunger, A., von Karstedt, S., Voss, A. K., Vousden, K. H., Vucic, D., Vuri, D., Wagner, E. F., Walczak, H., Wallach, D., Wang, R., Wang, Y., Weber, A., Wood, W., Yamazaki, T., Yang, H. T., Zakeri, Z., Zawacka-Pankau, J. E., Zhang, L., Zhang, H., Zhivotovsky, B., Zhou, W., Piacentini, M., Kroemer, G. & Galluzzi, L., 1 May 2023, In: Cell Death and Differentiation. 30, 5, p. 1097-1154 58 p.

    Research output: Contribution to journalReview articlepeer-review

    206 Scopus citations
  • Ecological network analysis reveals cancer-dependent chaperone-client interaction structure and robustness

    Galai, G., He, X., Rotblat, B. & Pilosof, S., 1 Dec 2023, In: Nature Communications. 14, 1, 6277.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    1 Scopus citations
  • Open Access
    1 Scopus citations
  • The Fitness Effects of Codon Composition of the Horizontally Transferred Antibiotic Resistance Genes Intensify at Sub-lethal Antibiotic Levels

    Shaferman, M., Gencel, M., Alon, N., Alasad, K., Rotblat, B., Serohijos, A. W. R., Alfonta, L. & Bershtein, S., 1 Jun 2023, In: Molecular Biology and Evolution. 40, 6, msad123.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    4 Scopus citations
  • EIF4EBP1 is transcriptionally upregulated by MYCN and associates with poor prognosis in neuroblastoma

    Voeltzke, K., Scharov, K., Funk, C. M., Kahler, A., Picard, D., Hauffe, L., Orth, M. F., Remke, M., Esposito, I., Kirchner, T., Schramm, A., Rotblat, B., Grünewald, T. G. P., Reifenberger, G. & Leprivier, G., 1 Dec 2022, In: Cell Death Discovery. 8, 1, 157.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    7 Scopus citations
  • Eukaryotic translation initiation factor 4E binding protein 1 (EIF4EBP1) expression in glioblastoma is driven by ETS1- and MYBL2-dependent transcriptional activation

    Hauffe, L., Picard, D., Musa, J., Remke, M., Grünewald, T. G. P., Rotblat, B., Reifenberger, G. & Leprivier, G., 1 Dec 2022, In: Cell Death Discovery. 8, 1, 91.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    13 Scopus citations
  • MEK1/2 inhibition transiently alters the tumor immune microenvironment to enhance immunotherapy efficacy against head and neck cancer

    Prasad, M., Zorea, J., Jagadeeshan, S., Shnerb, A. B., Mathukkada, S., Bouaoud, J., Michon, L., Novoplansky, O., Badarni, M., Cohen, L., Yegodayev, K. M., Tzadok, S., Rotblat, B., Brezina, L., Mock, A., Karabajakian, A., Fayette, J., Cohen, I., Cooks, T. & Allon, I. & 12 others, Dimitstein, O., Joshua, B., Kong, D., Voronov, E., Scaltriti, M., Carmi, Y., Conde-Lopez, C., Hess, J., Kurth, I., Morris, L. G. T., Saintigny, P. & Elkabets, M., 15 Mar 2022, In: Journal for ImmunoTherapy of Cancer. 10, 3, e003917.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    29 Scopus citations