Skip to main navigation Skip to search Skip to main content
Barak Rotblat

View Scopus Profile

Barak Rotblat

 https://orcid.org/0000-0003-2985-7115
20022025

Research activity per year

Personal profile

Research interests

Background

Previously depicted as the ‘dark matter of the genome’, it is becoming clearer that genes encoding long noncoding RNAs (lncRNA) are important players in all aspects of cell biology. LncRNAs are expressed in a tissue specific manner during development, have evolved in complex organisms and, surprisingly, are found in polysomes. What do these lncRNAs do? They bind proteins and regulate their activity (they do other things as well). While there are more than 10,000 different lncRNAs, only ~ 100 lncRNAs have been characterized to date and elucidating the functions these non coding RNAs have evolved to fulfil is our challenge.

Current Projects

1. We are studying lncRNAs that are important in brain cancer, glioblastoma, in general and in particular in glioblastoma cancer stem cells. 2. We are interested in how protein synthesis is regulated in the cells. We aim to learn more about the functions of lncRNAs in basic cell biology processes, in particular in regulation of protein translation. In cells, there is tight regulation of which RNAs will actually be translated. This is observed as specific RNAs partition between polysomal (translated) and non-polysomal (untranslated) fractions in resting and in stimulated conditions. We observed that lncRNA behave in a similar manner to coding mRNAs and we aim to elucidate their contribution to the translational landscape of the cell.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

Fingerprint

Dive into the research topics where Barak Rotblat is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
  • 1 Similar Profiles
View full fingerprint

Collaborations and top research areas from the last five years

Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Explore network further

  • Identifying sex-chromosome-linked determinants of sexual differentiation in a WZ-ZZ sex inheritance crustacean

    Wahl, M., Borojovich, Y., Levy, T., Asculai, N., Manor, R., Rotblat, B., Levin, L., Chalifa-Caspi, V., Aflalo, E. D. & Sagi, A., 1 Oct 2025, In: Biology of Reproduction. 113, 4, p. 838-855 18 p.

    Research output: Contribution to journal › Article › peer-review

    3 Scopus citations

  • Pharmacological activation of SIRT6 suppresses progression of head and neck and esophageal squamous cell carcinoma by modulation of cellular metabolism and protein translation

    Ben Lulu, T., Manikandan, D. B., Pevzner, Y., Sklarz, M., Eisdorfer, S. A., Awad, S., Mathukkada, S., Marripati, D., Wainer, M., Shimshilashvili-Kleiner, L., Ohana, E., Cohen, I., Zhang, J., Alassam, S. S., Rotblat, B., Wang, H., Kong, D., Cohen, O., Toiber, D. & Elkabets, M., 1 Dec 2025, In: Cell Death and Disease. 16, 1, 727.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    4 Scopus citations

  • The EIF4EBP1 gene encoding 4EBP1 is transcriptionally upregulated by MYC and linked to shorter survival in medulloblastoma

    Hruby, L., Schaal, K., Delaidelli, A., Picard, D., Dunham, C., Lewandowska, O., Reiff, T., Larcher, M., Pouponnot, C., Sorensen, P. H. B., Rotblat, B., Reifenberger, G., Remke, M. & Leprivier, G., 1 Dec 2025, In: Cell Death Discovery. 11, 1, 330.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Translon: a single term for translated regions

    TRANSLACORE, 1 Oct 2025, In: Nature Methods. 22, 10, p. 2002-2006 5 p.

    Research output: Contribution to journal › Letter › peer-review

    Open Access
    10 Scopus citations

  • Brillouin gain microscopy

    Shaashoua, R., Kasuker, L., Kishner, M., Levy, T., Rotblat, B., Ben-Zvi, A. & Bilenca, A., 1 Aug 2024, In: Nature Photonics. 18, 8, p. 836-841 6 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    13 Scopus citations

  • Enhancing Mechanical Stimulated Brillouin Scattering Imaging with Physics-Driven Model Selection

    Shaashoua, R., Levy, T., Rotblat, B. & Bilenca, A., 1 Jun 2024, In: Laser and Photonics Reviews. 18, 6, 2301054.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    6 Scopus citations

  • mTORC1 regulates cell survival under glucose starvation through 4EBP1/2-mediated translational reprogramming of fatty acid metabolism

    Levy, T., Voeltzke, K., Hruby, L., Alasad, K., Bas, Z., Snaebjörnsson, M., Marciano, R., Scharov, K., Planque, M., Vriens, K., Christen, S., Funk, C. M., Hassiepen, C., Kahler, A., Heider, B., Picard, D., Lim, J. K. M., Stefanski, A., Bendrin, K. & Vargas-Toscano, A. & 11 others, Kahlert, U. D., Stühler, K., Remke, M., Elkabets, M., Grünewald, T. G. P., Reichert, A. S., Fendt, S. M., Schulze, A., Reifenberger, G., Rotblat, B. & Leprivier, G., 1 Dec 2024, In: Nature Communications. 15, 1, 4083.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    39 Scopus citations

  • Apoptotic cell death in disease—Current understanding of the NCCD 2023

    Vitale, I., Pietrocola, F., Guilbaud, E., Aaronson, S. A., Abrams, J. M., Adam, D., Agostini, M., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., Aqeilan, R. I., Arama, E., Baehrecke, E. H., Balachandran, S., Bano, D., Barlev, N. A., Bartek, J. & Bazan, N. G. & 208 others, Becker, C., Bernassola, F., Bertrand, M. J. M., Bianchi, M. E., Blagosklonny, M. V., Blander, J. M., Blandino, G., Blomgren, K., Borner, C., Bortner, C. D., Bove, P., Boya, P., Brenner, C., Broz, P., Brunner, T., Damgaard, R. B., Calin, G. A., Campanella, M., Candi, E., Carbone, M., Carmona-Gutierrez, D., Cecconi, F., Chan, F. K. M., Chen, G. Q., Chen, Q., Chen, Y. H., Cheng, E. H., Chipuk, J. E., Cidlowski, J. A., Ciechanover, A., Ciliberto, G., Conrad, M., Cubillos-Ruiz, J. R., Czabotar, P. E., D’Angiolella, V., Daugaard, M., Dawson, T. M., Dawson, V. L., De Maria, R., De Strooper, B., Debatin, K. M., Deberardinis, R. J., Degterev, A., Del Sal, G., Deshmukh, M., Di Virgilio, F., Diederich, M., Dixon, S. J., Dynlacht, B. D., El-Deiry, W. S., Elrod, J. W., Engeland, K., Fimia, G. M., Galassi, C., Ganini, C., Garcia-Saez, A. J., Garg, A. D., Garrido, C., Gavathiotis, E., Gerlic, M., Ghosh, S., Green, D. R., Greene, L. A., Gronemeyer, H., Häcker, G., Hajnóczky, G., Hardwick, J. M., Haupt, Y., He, S., Heery, D. M., Hengartner, M. O., Hetz, C., Hildeman, D. A., Ichijo, H., Inoue, S., Jäättelä, M., Janic, A., Joseph, B., Jost, P. J., Kanneganti, T. D., Karin, M., Kashkar, H., Kaufmann, T., Kelly, G. L., Kepp, O., Kimchi, A., Kitsis, R. N., Klionsky, D. J., Kluck, R., Krysko, D. V., Kulms, D., Kumar, S., Lavandero, S., Lavrik, I. N., Lemasters, J. J., Liccardi, G., Linkermann, A., Lipton, S. A., Lockshin, R. A., López-Otín, C., Luedde, T., MacFarlane, M., Madeo, F., Malorni, W., Manic, G., Mantovani, R., Marchi, S., Marine, J. C., Martin, S. J., Martinou, J. C., Mastroberardino, P. G., Medema, J. P., Mehlen, P., Meier, P., Melino, G., Melino, S., Miao, E. A., Moll, U. M., Muñoz-Pinedo, C., Murphy, D. J., Niklison-Chirou, M. V., Novelli, F., Núñez, G., Oberst, A., Ofengeim, D., Opferman, J. T., Oren, M., Pagano, M., Panaretakis, T., Pasparakis, M., Penninger, J. M., Pentimalli, F., Pereira, D. M., Pervaiz, S., Peter, M. E., Pinton, P., Porta, G., Prehn, J. H. M., Puthalakath, H., Rabinovich, G. A., Rajalingam, K., Ravichandran, K. S., Rehm, M., Ricci, J. E., Rizzuto, R., Robinson, N., Rodrigues, C. M. P., Rotblat, B., Rothlin, C. V., Rubinsztein, D. C., Rudel, T., Rufini, A., Ryan, K. M., Sarosiek, K. A., Sawa, A., Sayan, E., Schroder, K., Scorrano, L., Sesti, F., Shao, F., Shi, Y., Sica, G. S., Silke, J., Simon, H. U., Sistigu, A., Stephanou, A., Stockwell, B. R., Strapazzon, F., Strasser, A., Sun, L., Sun, E., Sun, Q., Szabadkai, G., Tait, S. W. G., Tang, D., Tavernarakis, N., Troy, C. M., Turk, B., Urbano, N., Vandenabeele, P., Vanden Berghe, T., Vander Heiden, M. G., Vanderluit, J. L., Verkhratsky, A., Villunger, A., von Karstedt, S., Voss, A. K., Vousden, K. H., Vucic, D., Vuri, D., Wagner, E. F., Walczak, H., Wallach, D., Wang, R., Wang, Y., Weber, A., Wood, W., Yamazaki, T., Yang, H. T., Zakeri, Z., Zawacka-Pankau, J. E., Zhang, L., Zhang, H., Zhivotovsky, B., Zhou, W., Piacentini, M., Kroemer, G. & Galluzzi, L., 1 May 2023, In: Cell Death and Differentiation. 30, 5, p. 1097-1154 58 p.

    Research output: Contribution to journal › Review article › peer-review

    Open Access
    324 Scopus citations

  • Ecological network analysis reveals cancer-dependent chaperone-client interaction structure and robustness

    Galai, G., He, X., Rotblat, B. & Pilosof, S., 1 Dec 2023, In: Nature Communications. 14, 1, 6277.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    5 Scopus citations

  • Gene Expression and Drug Sensitivity Analysis of Mitochondrial Chaperones Reveals That HSPD1 and TRAP1 Expression Correlates with Sensitivity to Inhibitors of DNA Replication and Mitosis

    Badarni, M., Gabbay, S., Elkabets, M. & Rotblat, B., 1 Jul 2023, In: Biology. 12, 7, 988.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    2 Scopus citations
View all 75 Research outputs