Personal profile
Research interests
My lab studies genet and genomic aspects of mitochondrial functiona and evolution. We are interested in the functional potential and outcome of genetic variants, in transcriptional regulation of the mitochondrial genome, mit-nuclear co-evolution and co-regulation.
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Collaborations and top research areas from the last five years
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Hypoxia leads to reduced mito-nuclear gene expression and increased mtDNA transcriptional pausing in human cells
Shtolz, N., Dadon, S. & Mishmar, D., 1 Dec 2026, In: Communications Biology. 9, 1, 180.Research output: Contribution to journal › Article › peer-review
Open Access -
The functional importance of mitochondrial sequences with dual functions: overlapping protein-protein and protein-RNA gene sequences as test cases
Shtolz, N., Horovitz, L., Caruchero, Y. & Mishmar, D., 2 Apr 2026, In: Philosophical Transactions of the Royal Society B: Biological Sciences. 381, 1947Research output: Contribution to journal › Article › peer-review
Open Access -
Coevolution Between the Mitochondrial and Nuclear Genomes
Mishmar, D., 1 Jan 2025, Encyclopedia of Evolutionary Biology. Elsevier, p. V2:56-V2:66Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
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Vertebrates show coordinated elevated expression of mitochondrial and nuclear genes after birth
Medini, H. & Mishmar, D., 1 Mar 2025, In: Genome Research. 35, 3, p. 459-474 16 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
The metazoan landscape of mitochondrial DNA gene order and content is shaped by selection and affects mitochondrial transcription
Shtolz, N. & Mishmar, D., 1 Dec 2023, In: Communications Biology. 6, 1, 93.Research output: Contribution to journal › Article › peer-review
Open Access39 Scopus citations -
Universities should denounce terrorism and antisemitism
Mishmar, D., Carmel, L., Shema, E. & Falik-Zaccai, T., 16 Nov 2023, In: Nature. 623, 7987, p. 483 1 p.Research output: Contribution to journal › Comment/debate
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Coordination of mitochondrial and nuclear gene-expression regulation in health, evolution, and disease
Papier, O., Minor, G., Medini, H. & Mishmar, D., 1 Jun 2022, In: Current Opinion in Physiology. 27, 100554.Research output: Contribution to journal › Review article › peer-review
8 Scopus citations -
Erratum: Human primitive brain displays negative mitochondrial-nuclear expression correlation of respiratory genes (Genome Research (2018) 28 (952-967) DOI: 10.1101/gr.226324.117)
Barshad, G., Blumberg, A., Cohen, T. & Mishmar, D., 1 Aug 2022, In: Genome Research. 32, 8, p. 1626 1 p.Research output: Contribution to journal › Comment/debate
Open Access -
Human mitochondrial RNA modifications associate with tissue-specific changes in gene expression, and are affected by sunlight and UV exposure
Cohen, T., Medini, H., Mordechai, C., Eran, A. & Mishmar, D., 1 Dec 2022, In: European Journal of Human Genetics. 30, 12, p. 1363-1372 10 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Mutant C. elegans mitofusin leads to selective removal of mtDNA heteroplasmic deletions across generations to maintain fitness
Meshnik, L., Bar-Yaacov, D., Kasztan, D., Neiger, T., Cohen, T., Kishner, M., Valenci, I., Dadon, S., Klein, C. J., Vance, J. M., Nevo, Y., Züchner, S., Ovadia, O., Mishmar, D. & Ben-Zvi, A., 1 Dec 2022, In: BMC Biology. 20, 1, 40.Research output: Contribution to journal › Article › peer-review
Open Access19 Scopus citations
Equipment
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Mishmar Lab - Mitochondrial Genomics and Evolution
Mishmar, D. (PI)
Department of Life SciencesEquipment/facility: lab
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Re-expression of YAP for beta-cell regeneration; beta-reYAP
Maedler, K. K. (PI) & Mishmar, D. (CoPI)
1/01/23 → …
Project: Research
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Mitochondrial genomics and evolution
Mishmar, D. (PI) & Ostersetzer-Biran, O. (CoPI)
1/01/17 → …
Project: Research
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a. Various instruments for tissue culture. FACS Calibur 4 Colour Analyser, Becton Dickinson (BD)
Mishmar, D. (PI)
1/01/05 → …
Project: Research
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Exploring mitochondrial transcriptional regulation across metazoan evolution
Mishmar, D. (PI)
1/01/21 → 31/12/24
Project: Research
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Investigating the higher order organization of the mitochondrial genome – physiological impact and evolutionary perspective
Mishmar, D. (PI)
1/01/17 → 31/12/20
Project: Research
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Investigating the higher order organization of the mitochondrial genome – physiological impact and evolutionary perspective
Mishmar, D. (PI)
1/01/17 → 31/12/20
Project: Research
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Evolutionary-based approach to decipher the interactions between subunits within human oxidative phosphorylation complex I
Mishmar, D. (PI)
1/01/12 → 31/12/15
Project: Research
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The involvement of natural mitochondrial genetic variation in humans in the regulation of mitochondrial DNA replication and maintenance
Shlomai, J. J. (PI) & Mishmar, D. (CoPI)
1/01/07 → 31/12/09
Project: Research
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Mitochondrial DNA genetic diversity and complex disorders: complications in type II diabetes mellitus (DM) as a model
Mishmar, D. (PI)
1/01/05 → 31/12/07
Project: Research