Personal profile

Research interests

In all cells, regulated proteolytic events constantly sculpt and shape the proteome. In response to environmental conditions, proteolysis regulates cellular activities by adjusting gene expression, signal transduction and enzymatic activities. Equally important, intracellular proteolysis is a fundamental wing of protein quality control systems, as it eliminates misfolded proteins, especially under folding-stress conditions.

The enzymes that carry out most of the intracellular regulated proteolysis are AAA+ proteases. These are complex molecular machines that couple ATP-hydrolysis to substrate processing and degradation. These enzymes were carefully select their substrates and carry out proteolysis in a highly regulated manner that minimizes recognition errors, thereby allows intracellular proteolysis to proceed without damaging cell functioning.

Our lab use bacterial model systems to study the substrate-recognition principles and the mechanism of protein degradation by AAA+ proteases. In addition, as proteolysis regulates the virulence of many pathogenic bacteria, we develop inhibitors of AAA+ proteases and proteolytic pathways with the aim of using them as antibiotic compounds.
Check out our the Gur lab website at to learn more.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being


Dive into the research topics where Eyal Gur is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
  • 1 Similar Profiles

Collaborations and top research areas from the last five years

Recent external collaboration on country/territory level. Dive into details by clicking on the dots or