Research output per year
Research output per year
Personal profile
Research interests
- Developing stem-cell (iPSC) based personalized platforms of the human BBB in order to study diversity in brain penetrability among individuals.
- Elucidating the role of the BBB in neurological disease using patient-specific stem cells (iPSCs).
- Studying cell-to-cell interactions between the various cells of the neurovascular unit (NVU) e.g. brain endothelial cells, pericytes, astrocytes and neurons.
- Studying the mechanisms underlying leukodystrophys (diseases of the white matter), and development of translational cell-therapy approaches.
- Pre-clinical development of translational strategies for BBB-targeted gene therapy, to treat the Allan Herndon Dudley syndrome (AHDS, also known as MCT8-deficiency).
Research interests
- Our research aims to understand the mechanisms that underlie neurological disorders and develop personalized therapeutic approaches for patients. We use patient-specific stem cells to recreate diseases in a dish. Our main interest is to study the role of the blood brain barrier (BBB) in neurological disorders.
Research interests
- Developing stem-cell (iPSC) based personalized platforms of the human BBB in order to study diversity in brain penetrability among individuals.
- Elucidating the role of the BBB in neurological disease using patient-specific stem cells (iPSCs).
- Studying cell-to-cell interactions between the various cells of the neurovascular unit (NVU) e.g.brain endothelial cells, pericytes, astrocytes and neurons.-----
- Studying the mechanisms underlying leukodystrophys (diseases of the white matter), and development of translational cell-therapy approaches.
- Pre-clinical development of translational strategies for BBB-targeted gene therapy, to treat the Allan Herndon Dudley syndrome (AHDS, also known as MCT8-deficiency).
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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Chronic and acute exposure to rotenone reveals distinct Parkinson's disease-related phenotypes in human iPSC-derived peripheral neurons
Saleh, M. A., Amer-Sarsour, F., Berant, A., Pasmanik-Chor, M., Kobo, H., Sharabi, Y., Vatine, G. D. & Ashkenazi, A., 1 Mar 2024, In: Free Radical Biology and Medicine. 213, p. 164-173 10 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Disease-associated polyalanine expansion mutations impair UBA6-dependent ubiquitination
Amer-Sarsour, F., Falik, D., Berdichevsky, Y., Kordonsky, A., Eid, S., Rabinski, T., Ishtayeh, H., Cohen-Adiv, S., Braverman, I., Blumen, S. C., Laviv, T., Prag, G., Vatine, G. D. & Ashkenazi, A., 16 Jan 2024, In: EMBO Journal. 43, 2, p. 250-276 27 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Impedance Characteristics of Microfluidic Channels and Integrated Coplanar Parallel Electrodes as Design Parameters for Whole-Channel Analysis in Organ-on-Chip Micro-Systems
Rapier, C. E., Jagadeesan, S., Vatine, G. D. & Ben-Yoav, H., 1 Aug 2024, In: Biosensors. 14, 8, 374.Research output: Contribution to journal › Article › peer-review
Open Access -
Early maturation and hyperexcitability is a shared phenotype of cortical neurons derived from different ASD-associated mutations
Hussein, Y., Tripathi, U., Choudhary, A., Nayak, R., Peles, D., Rosh, I., Rabinski, T., Djamus, J., Vatine, G. D., Spiegel, R., Garin-Shkolnik, T. & Stern, S., 1 Dec 2023, In: Translational Psychiatry. 13, 1, 246.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
AAV9-MCT8 Delivery at Juvenile Stage Ameliorates Neurological and Behavioral Deficits in a Mouse Model of MCT8-Deficiency
Liao, X. H., Avalos, P., Shelest, O., Ofan, R., Shilo, M., Bresee, C., Likhite, S., Vit, J. P., Heuer, H., Kaspar, B., Meyer, K., Dumitrescu, A. M., Refetoff, S., Svendsen, C. N. & Vatine, G. D., 1 Jul 2022, In: Thyroid. 32, 7, p. 849-859 11 p.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
Microfluidic channel sensory system for electro-addressing cell location, determining confluency, and quantifying a general number of cells
Rapier, C. E., Jagadeesan, S., Vatine, G. & Ben-Yoav, H., 1 Dec 2022, In: Scientific Reports. 12, 1, 3248.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
P450 oxidoreductase regulates barrier maturation by mediating retinoic acid metabolism in a model of the human BBB
Zlotnik, D., Rabinski, T., Halfon, A., Anzi, S., Plaschkes, I., Benyamini, H., Nevo, Y., Gershoni, O. Y., Rosental, B., Hershkovitz, E., Ben-Zvi, A. & Vatine, G. D., 13 Sep 2022, In: Stem Cell Reports. 17, 9, p. 2050-2063 14 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
PLEKHM2 Loss of Function Impairs the Activity of iPSC-Derived Neurons via Regulation of Autophagic Flux
Ben-Zvi, H., Rabinski, T., Ofir, R., Cohen, S. & Vatine, G. D., 1 Dec 2022, In: International Journal of Molecular Sciences. 23, 24, 16092.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
SnapShot: Autonomic nervous system disorders
Sharabi, Y., Vatine, G. D. & Ashkenazi, A., 20 Apr 2022, In: Neuron. 110, 8, p. 1432-1432.e1Research output: Contribution to journal › Comment/debate
Open Access1 Scopus citations -
Sodium Phenylbutyrate Rescues Thyroid Hormone Transport in Brain Endothelial-Like Cells
Braun, D., Bohleber, S., Vatine, G. D., Svendsen, C. N. & Schweizer, U., 1 Jul 2022, In: Thyroid. 32, 7, p. 860-870 11 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations