Personal profile
Research interests
- Developing stem-cell (iPSC) based personalized platforms of the human BBB in order to study diversity in brain penetrability among individuals.
- Elucidating the role of the BBB in neurological disease using patient-specific stem cells (iPSCs).
- Studying cell-to-cell interactions between the various cells of the neurovascular unit (NVU) e.g. brain endothelial cells, pericytes, astrocytes and neurons.
- Studying the mechanisms underlying leukodystrophys (diseases of the white matter), and development of translational cell-therapy approaches.
- Pre-clinical development of translational strategies for BBB-targeted gene therapy, to treat the Allan Herndon Dudley syndrome (AHDS, also known as MCT8-deficiency).
Research interests
- Our research aims to understand the mechanisms that underlie neurological disorders and develop personalized therapeutic approaches for patients. We use patient-specific stem cells to recreate diseases in a dish. Our main interest is to study the role of the blood brain barrier (BBB) in neurological disorders.
Research interests
- Developing stem-cell (iPSC) based personalized platforms of the human BBB in order to study diversity in brain penetrability among individuals.
- Elucidating the role of the BBB in neurological disease using patient-specific stem cells (iPSCs).
- Studying cell-to-cell interactions between the various cells of the neurovascular unit (NVU) e.g.brain endothelial cells, pericytes, astrocytes and neurons.-----
- Studying the mechanisms underlying leukodystrophys (diseases of the white matter), and development of translational cell-therapy approaches.
- Pre-clinical development of translational strategies for BBB-targeted gene therapy, to treat the Allan Herndon Dudley syndrome (AHDS, also known as MCT8-deficiency).
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Collaborations and top research areas from the last five years
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A novel electrochemical sensor for in situ analysis of neurotransmitter profiles generated by induced pluripotent stem cell-derived neurons
Shalabny, N., Saleh, M. A., Snezhko, A., Vatine, G. D. & Ben-Yoav, H., 1 Dec 2025, In: Sensing and Bio-Sensing Research. 50, 100894.Research output: Contribution to journal › Article › peer-review
Open Access -
A Novel Pathogenic Variant Identified in HIKESHI-Related Hypomyelinating Leukodystrophy Disrupts Heat Shock Response in iPSCs
Saleh, M. A., Boichuck, M., Ottolenghi, A., Rabinski, T., Goldenthal, O., Sanchez, D. S., Fattal-Valevski, A., Heimer, G., Ben-Shachar, S., Libzon, S., Gershoni-Yahalom, O., Ben-Zvi, A., Zarivach, R., Zerem, A., Rosental, B. & Vatine, G. D., 1 Jul 2025, In: International Journal of Molecular Sciences. 26, 13, 6037.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Membrane Permeability Monitoring to Antipsychotic Olanzapine Using Platinum Black-Modified Electrodes
Ilango, M. S., Desagani, D., Jagadeesan, S., Snezhko, A., Vatine, G. & Ben-Yoav, H., 1 Apr 2025, In: Sensors. 25, 7, 2266.Research output: Contribution to journal › Article › peer-review
Open Access -
Proteomic analysis of human iPSC-derived sympathetic neurons identifies proteostasis collapse as a molecular signature following subtoxic rotenone exposure
Gordon, T., Saleh, M. A., Pasmanik-Chor, M., Vatine, G. D. & Ashkenazi, A., 1 Jan 2025, In: Toxicology. 510, 154015.Research output: Contribution to journal › Article › peer-review
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Chronic and acute exposure to rotenone reveals distinct Parkinson's disease-related phenotypes in human iPSC-derived peripheral neurons
Saleh, M. A., Amer-Sarsour, F., Berant, A., Pasmanik-Chor, M., Kobo, H., Sharabi, Y., Vatine, G. D. & Ashkenazi, A., 1 Mar 2024, In: Free Radical Biology and Medicine. 213, p. 164-173 10 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Disease-associated polyalanine expansion mutations impair UBA6-dependent ubiquitination
Amer-Sarsour, F., Falik, D., Berdichevsky, Y., Kordonsky, A., Eid, S., Rabinski, T., Ishtayeh, H., Cohen-Adiv, S., Braverman, I., Blumen, S. C., Laviv, T., Prag, G., Vatine, G. D. & Ashkenazi, A., 16 Jan 2024, In: EMBO Journal. 43, 2, p. 250-276 27 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Impedance Characteristics of Microfluidic Channels and Integrated Coplanar Parallel Electrodes as Design Parameters for Whole-Channel Analysis in Organ-on-Chip Micro-Systems
Rapier, C. E., Jagadeesan, S., Vatine, G. D. & Ben-Yoav, H., 1 Aug 2024, In: Biosensors. 14, 8, 374.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Early maturation and hyperexcitability is a shared phenotype of cortical neurons derived from different ASD-associated mutations
Hussein, Y., Tripathi, U., Choudhary, A., Nayak, R., Peles, D., Rosh, I., Rabinski, T., Djamus, J., Vatine, G. D., Spiegel, R., Garin-Shkolnik, T. & Stern, S., 1 Dec 2023, In: Translational Psychiatry. 13, 1, 246.Research output: Contribution to journal › Article › peer-review
Open Access35 Scopus citations -
AAV9-MCT8 Delivery at Juvenile Stage Ameliorates Neurological and Behavioral Deficits in a Mouse Model of MCT8-Deficiency
Liao, X. H., Avalos, P., Shelest, O., Ofan, R., Shilo, M., Bresee, C., Likhite, S., Vit, J. P., Heuer, H., Kaspar, B., Meyer, K., Dumitrescu, A. M., Refetoff, S., Svendsen, C. N. & Vatine, G. D., 1 Jul 2022, In: Thyroid. 32, 7, p. 849-859 11 p.Research output: Contribution to journal › Article › peer-review
Open Access22 Scopus citations -
Microfluidic channel sensory system for electro-addressing cell location, determining confluency, and quantifying a general number of cells
Rapier, C. E., Jagadeesan, S., Vatine, G. & Ben-Yoav, H., 1 Dec 2022, In: Scientific Reports. 12, 1, 3248.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations
Press/Media
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The function of circular RNAs in fragile X syndrome
Appelbaum, L. (PI) & Vatine, G. (CoPI)
Simons Foundation Autism Research Initiative
1/01/25 → …
Project: Research
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Pre-clinical assessment of gene therapy treatment for MCT8-deficiency
Vatine, G. (PI)
1/01/22 → 1/01/27
Project: Research
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Equipment for establishment of neurological disease modeling lab
Vatine, G. (PI)
1/01/18 → …
Project: Research
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The role of MCT8 in human blood brain barrier functioning using patient-specific induced pluripotent stem cells
Vatine, G. (PI)
1/01/18 → 31/12/21
Project: Research
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The role of MCT8 in human blood brain barrier functioning using patient-specific induced pluripotent stem cells
Vatine, G. (PI)
1/01/18 → 31/12/21
Project: Research