Research output per year
Research output per year
Personal profile
Research interests
Background
Flagella are organelles that facilitate locomotion of single cells, such as bacteria, archaea, algae, parasites, and human sperm. These cells depend on motility to find nutrients, escape threats, and mate. Flagella structure and mechanism vary among domains (Bacteria, Archaea, Eukarya), but all are complex molecular machines that power cell motility.
Current Projects
We use methods in biochemistry and structural biology (especially cryo-EM) to decipher the structure of flagella, and thereby their beating mechanisms. We are currently focusing on flagella from haloarchaea (salt-loving extremophiles) and eukaryotic parasites, which rely on their flagella to survive.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Keywords
- Q Science (General)
- Structural Biology
- Protein complexes
- haloarchaea
- flagella
- eukaryotic parasites
Fingerprint
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Perturbed N-glycosylation of Halobacterium salinarum archaellum filaments leads to filament bundling and compromised cell motility
Sofer, S., Vershinin, Z., Mashni, L., Zalk, R., Shahar, A., Eichler, J. & Grossman-Haham, I., 1 Dec 2024, In: Nature Communications. 15, 1, 5841.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Towards an atomic model of a beating ciliary axoneme
Grossman-Haham, I., 1 Feb 2023, In: Current Opinion in Structural Biology. 78, 102516.Research output: Contribution to journal › Review article › peer-review
4 Scopus citations -
Structure of the radial spoke head and insights into its role in mechanoregulation of ciliary beating
Grossman-Haham, I., Coudray, N., Yu, Z., Wang, F., Zhang, N., Bhabha, G. & Vale, R. D., 1 Jan 2021, In: Nature Structural and Molecular Biology. 28, 1, p. 20-28 9 p.Research output: Contribution to journal › Article › peer-review
Open Access36 Scopus citations -
Erratum: Inhibition of fibroblast secreted QSOX1 perturbs extracellular matrix in the tumor microenvironment and decreases tumor growth and metastasis in murine cancer models (Oncotarget (2020) 11 (386-398) DOI: 10.18632/oncotarget.27438)
Feldman, T., Grossman-Haham, I., Elkis, Y., Vilela, P., Moskovits, N., Barshack, I., Salame, T. M., Fass, D. & Ilani, T., 6 Oct 2020, In: Oncotarget. 11, 40, p. 3687 1 p.Research output: Contribution to journal › Comment/debate
Open Access -
Inhibition of fibroblast secreted QSOX1 perturbs extracellular matrix in the tumor microenvironment and decreases tumor growth and metastasis in murine cancer models
Feldman, T., Grossman-Haham, I., Elkis, Y., Vilela, P., Moskovits, N., Barshack, I., Salame, T. M., Fass, D. & Ilani, T., 28 Jan 2020, In: Oncotarget. 11, 4, p. 386-398 13 p.Research output: Contribution to journal › Article › peer-review
Open Access14 Scopus citations -
cis-Proline mutants of quiescin sulfhydryl oxidase 1 with altered redox properties undermine extracellular matrix integrity and cell adhesion in fibroblast cultures
Javitt, G., Grossman-Haham, I., Alon, A., Resnick, E., Mutsafi, Y., Ilani, T. & Fass, D., 1 Jan 2019, In: Protein Science. 28, 1, p. 228-238 11 p.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
Slow domain reconfiguration causes power-law kinetics in a two-state enzyme
Grossman-Haham, I., Rosenblum, G., Namani, T. & Hofmann, H., 16 Jan 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 3, p. 513-518 6 p.Research output: Contribution to journal › Article › peer-review
Open Access28 Scopus citations -
Overcoming a species-specificity barrier in development of an inhibitory antibody targeting a modulator of tumor stroma
Grossman, I., Ilani, T., Fleishman, S. J. & Fass, D., 1 Apr 2016, In: Protein Engineering, Design and Selection. 29, 4, p. 135-147 13 p.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
Single-molecule spectroscopy exposes hidden states in an enzymatic electron relay
Grossman, I., Aviram, H. Y., Armony, G., Horovitz, A., Hofmann, H., Haran, G. & Fass, D., 15 Oct 2015, In: Nature Communications. 6, 8624.Research output: Contribution to journal › Article › peer-review
Open Access14 Scopus citations -
Enzyme structure captures four cysteines aligned for disulfide relay
Gat, Y., Vardi-Kilshtain, A., Grossman, I., Major, D. T. & Fass, D., 1 Jan 2014, In: Protein Science. 23, 8, p. 1102-1112 11 p.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations
Equipment
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Grossman-Haham Lab - Structural studies flagella
Grossman-Haham, I. (PI)
Department of Life SciencesEquipment/facility: lab