Research output per year
Research output per year
Personal profile
Research interests
Long-held to be a post-translational modification unique to Eukarya, it is now clear that Bacteria and Archaea also perform N-glycosylation, the covalent linkage of glycans to select asparagine residues of target proteins. However, whereas such protein processing is restricted to a limited number of bacterial groups, N-glycosylation is an almost universal event in the Archaea. Work in our lab seeks to better understand the archaeal version of this universal post-translational modification using bioinformatics, genetic, biochemical, and structural approaches.
Education/Academic qualification
PhD, Molecular forms of acetylcholinesterase: Regulation at the biosynthetic, ultrastructural and molecular levels, Weizmann Institute of Science
Award Date: 1 Sep 1994
Master, The immunocytochemical localization of phosphatidylinositol-anchored acetylcholinesterase in excitable tissues of Torpedo ocellata, Weizmann Institute of Science
Award Date: 1 Sep 1988
Bachelor, McGill University
Award Date: 1 Sep 1985
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Collaborations and top research areas from the last five years
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Distinct properties ofHalobacterium salinarumAgl32, an archaeal D-glucuronyl C5-epimerase involved in N-glycosylation
Aquilone, A., Levi, Y., Zaretsky, M., Vershinin, Z., Grossman-Haham, I., De Castro, C. & Eichler, J., 1 Aug 2026, In: Glycobiology. 36, 8, cwag045.Research output: Contribution to journal › Article › peer-review
Open Access -
Only in Halobacterium salinarum: Sugar modifications unique to an archaeal N-linked glycan
Eichler, J., Vershinin, Z. & Zaretsky, M., 1 Apr 2026, In: Carbohydrate Research. 562, 109817.Research output: Contribution to journal › Article › peer-review
Open Access -
Cuticular proteins (crusticuls) affect 3D chitin bundle nanostructure
Shaked, S. A., Weil, S., Manor, R., Aflalo, E. D., Moscovitz, S., Maman, N., Maria, R., Kruppke, B., Hanke, T., Eichler, J., Ratzker, B., Sokol, M. & Sagi, A., 17 May 2025, In: Nanoscale. 17, 22, p. 13951-13965 15 p.Research output: Contribution to journal › Article › peer-review
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Identification of the D-glucuronyl C5-epimerase that introduces iduronic acid into N-linked glycans decorating archaeal glycoproteins
Vershinin, Z., Zaretsky, M., Notaro, A., Yu, D., Molinaro, A., Sofer, S., Grossman-Haham, I., De Castro, C. & Eichler, J., 1 Dec 2025, In: Communications Biology. 8, 1, 1591.Research output: Contribution to journal › Article › peer-review
Open Access -
Two different sulfotransferases modify sugars of the N-linked tetrasaccharide decorating Halobacterium salinarum glycoproteins
Zaretsky, M., Vershinin, Z., Erez, L., Grossman-Haham, I. & Eichler, J., 1 Apr 2025, In: mBio. 16, 4Research output: Contribution to journal › Article › peer-review
Open Access -
A transporter that allows phosphate ions to control the polymorph of exoskeletal calcium carbonate biomineralization
Shaked, S. A., Abehsera, S., Ziegler, A., Bentov, S., Manor, R., Weil, S., Ohana, E., Eichler, J., Aflalo, E. D. & Sagi, A., 1 Apr 2024, In: Acta Biomaterialia. 178, p. 221-232 12 p.Research output: Contribution to journal › Article › peer-review
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N-glycosylation in Archaea – Expanding the process, components and roles of a universal post-translational modification
Vershinin, Z., Zaretsky, M. & Eichler, J., 1 Jan 2024, In: BBA Advances. 6, 100120.Research output: Contribution to journal › Article › peer-review
Open Access -
Perturbed N-glycosylation of Halobacterium salinarum archaellum filaments leads to filament bundling and compromised cell motility
Sofer, S., Vershinin, Z., Mashni, L., Zalk, R., Shahar, A., Eichler, J. & Grossman-Haham, I., 1 Dec 2024, In: Nature Communications. 15, 1, 5841.Research output: Contribution to journal › Article › peer-review
Open Access -
The Bacterial Proteasome Inter-domain Is a Selectivity Barrier for Degradation-tag Binding
Mor-Rashti, Z., Levin, R., Eichler, J. & Gur, E., 15 Mar 2024, In: Journal of Molecular Biology. 436, 6, 168462.Research output: Contribution to journal › Article › peer-review
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The sequence of events of enteropathogenic E. coli's type III secretion system translocon assembly
Gershberg, J., Morhaim, M., Rostrovsky, I., Eichler, J. & Sal-Man, N., 15 Mar 2024, In: iScience. 27, 3, 109108.Research output: Contribution to journal › Article › peer-review
Open Access
Press/Media
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Ben-Gurion University of the Negev Reports Findings in Nanostructures [Cuticular proteins (crusticuls) affect 3D chitin bundle nanostructure]
Manor, R., Maman, N., Eichler, J., Sagi, A., Moscovitz, S., Shaked, S. A., Aflalo, E.-D. & Weil, S.
4/06/25
1 item of Media coverage
Press/Media
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Linking Halobacterium salinarum N-glycosylation to cellular processes
Eichler, J. (PI)
1/01/25 → 31/12/28
Project: Research
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Surface Enhanced Raman Spectroscopy of Bacteria
Efrima, S. (PI), Eichler, J. (CoPI), Shabtai, Y. (CoPI) & Bronk, B. (CoPI)
United States-Israel Binational Science Foundation (BSF)
1/01/98 → …
Project: Research
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A plasmid goes viral: Understanding the origin and evolution of viruses by studying a newly discovered virus-like element.
Erdmann, S. (PI), Tischler, N. N. (CoPI), Eichler, J. (CoPI), Eichler, J. J. (CoPI) & Huiskonen, J. J. (CoPI)
7/07/20 → 6/07/23
Project: Research
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Exploring N-glycosylation in Halobacterium salinarum at the transcript, protein, lipid carrier and cellular levels
Eichler, J. (PI)
1/01/20 → 31/12/23
Project: Research
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Protein glycosylation in Haloarcula hispanica: A new model for understanding a post-translational modification in Archaea
Eichler, J. (PI), Jin, C. C. (CoPI), Yang, J. J. (CoPI), Yang, L. L. (CoPI), Ouyang, H. H. (CoPI), Lu, H. H. (CoPI), Xu, Y. Y. (CoPI), Zhang, X. X. (CoPI) & Pei, C. C. (CoPI)
1/01/16 → 1/01/19
Project: Research
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Molecular characterization of N-glycosylation pathways in halophilic Archaea
Eichler, J. (PI)
1/01/16 → 31/12/18
Project: Research
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Using chemoenzymatic synthesis to study archaeal N-glycosylation
Eichler, J. (PI) & Kulkarni, S. S. (CoPI)
1/01/15 → 1/01/18
Project: Research
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N-glycosylation in Archaea: A post-translational modification of extremophilic proteins
Eichler, J. (PI)
1/01/11 → 31/12/14
Project: Research
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Protein N-glycosylation in Archaea: Post-translational modification in extreme conditions
Eichler, J. (PI)
1/01/07 → 31/12/10
Project: Research
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Molecular dynamics of preprotein translocation across biological membranes
Eichler, J. (CoPI) & Wickner, W. (PI)
Human Frontier Science Program
1/01/95 → 31/12/97
Project: Research