Research output per year
Research output per year
Personal profile
Research interests
| The Hershfinkel laboratory is investigating the pathways that are activated by zinc to mediate physiological functions. Zinc is an essential micronutrient and plays a central role in the function of the skin, nervous and digestive systems.As many as 24 zinc transporters are involved in maintaining the cellular levels of zinc, and transport this metal ion across cellular and organellar membranes. | |
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Our lab identified a distinct zinc sensing receptor, ZnR/GPR39, that upon changes in extracellular zinc levels triggers major signaling pathways in epithelial cells and neurons. We focus on revealing the physiological roles of ZnR/GPR39.
As many as 24 zinc transporters are involved in maintaining the cellular levels of zinc, and transport this metal ion across cellular and organellar membranes. Our lab identified a distinct zinc sensing receptor, ZnR/GPR39, that upon changes in extracellular zinc levels triggers major signaling pathways in epithelial cells and neurons. We focus on revealing the physiological roles of ZnR/GPR39.
Using molecular biology, biochemistry and live cell imaging techniques we study how zinc ions are transported into the cell, which signaling pathways they activate, and how they regulate important ion transporters to control cell survival, as well as water absorption in the digestive system, salivary gland secretion and seizure.
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Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Keywords
- QP Physiology
- Zinc biology
- Zinc signaling
- Calcium signaling
- Cancer
- Neuroscience
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Collaborations and top research areas from the last five years
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Cross-talk between zinc and calcium regulates ion transport: A role for the zinc receptor, ZnR/GPR39
Hershfinkel, M., 15 Apr 2024, In: Journal of Physiology. 602, 8, p. 1579-1594 16 p.Research output: Contribution to journal › Review article › peer-review
Open Access3 Scopus citations -
NCLX controls hepatic mitochondrial Ca2+ extrusion and couples hormone-mediated mitochondrial Ca2+ oscillations with gluconeogenesis
Taha, M., Assali, E. A., Ben-Kasus Nissim, T., Stutzmann, G. E., Shirihai, O. S., Hershfinkel, M. & Sekler, I., 1 Sep 2024, In: Molecular Metabolism. 87, 101982.Research output: Contribution to journal › Article › peer-review
Open Access -
The Concise Guide to PHARMACOLOGY 2023/24: Transporters
Alexander, S. P. H., Fabbro, D., Kelly, E., Mathie, A. A., Peters, J. A., Veale, E. L., Armstrong, J. F., Faccenda, E., Harding, S. D., Davies, J. A., Amarosi, L., Anderson, C. M. H., Beart, P. M., Broer, S., Dawson, P. A., Gyimesi, G., Hagenbuch, B., Hammond, J. R., Hancox, J. C. & Hershfinkel, M. & 8 others, , 1 Oct 2023, In: British Journal of Pharmacology. 180, S2, p. S374-S469Research output: Contribution to journal › Article › peer-review
Open Access39 Scopus citations -
CKII Control of Axonal Plasticity Is Mediated by Mitochondrial Ca2+ via Mitochondrial NCLX
Katoshevski, T., Bar, L., Tikochinsky, E., Harel, S., Ben-Kasus Nissim, T., Bogeski, I., Hershfinkel, M., Attali, B. & Sekler, I., 9 Dec 2022, In: Cells. 11, 24, 3990.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Essential role of the mitochondrial Na+/Ca2+ exchanger NCLX in mediating PDE2-dependent neuronal survival and learning
Rozenfeld, M., Azoulay, I. S., Ben Kasus Nissim, T., Stavsky, A., Melamed, M., Stutzmann, G., Hershfinkel, M., Kofman, O. & Sekler, I., 6 Dec 2022, In: Cell Reports. 41, 10, 111772.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
SNAP23 regulates KCC2 membrane insertion and activity following mZnR/GPR39 activation in hippocampalneurons
Asraf, H., Bogdanovic, M., Gottesman, N., Sekler, I., Aizenman, E. & Hershfinkel, M., 18 Feb 2022, In: iScience. 25, 2, 103751.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
The ZIP3 Zinc Transporter Is Localized to Mossy Fiber Terminals and Is Required for Kainate-Induced Degeneration of CA3 Neurons
Bogdanovic, M., Asraf, H., Gottesman, N., Sekler, I., Aizenman, E. & Hershfinkel, M., 30 Mar 2022, In: Journal of Neuroscience. 42, 13, p. 2824-2834 11 p.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
ZnT1 is a neuronal Zn2+/Ca2+ exchanger
Gottesman, N., Asraf, H., Bogdanovic, M., Sekler, I., Tzounopoulos, T., Aizenman, E. & Hershfinkel, M., Jan 2022, In: Cell Calcium. 101, 12 p., 102505.Research output: Contribution to journal › Article › peer-review
14 Scopus citations -
Zinc signaling in the mammary gland: For better and for worse
Chakraborty, M. & Hershfinkel, M., 1 Sep 2021, In: Biomedicines. 9, 9, 1204.Research output: Contribution to journal › Review article › peer-review
Open Access4 Scopus citations -
ZnR/GPR39 controls cell migration by orchestrating recruitment of KCC3 into protrusions, re-organization of actin and activation of MMP
Chakraborty, M., Asraf, H., Sekler, I. & Hershfinkel, M., 1 Mar 2021, In: Cell Calcium. 94, 102330.Research output: Contribution to journal › Article › peer-review
6 Scopus citations
Projects
- 1 Active
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Zinc homeostasis and cortical responses to sound
Hershfinkel, M. (PI), Aizenman, E. (CoPI) & Tzounopoulos, T. (CoPI)
United States-Israel Binational Science Foundation (BSF)
1/01/16 → …
Project: Research