Niv Papo

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84 Article
3 Review article
1 Meeting Abstract
1 Editorial
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- 1 Patent

Machine-learning prediction of affinity and epistasis in the bovine pancreatic trypsin inhibitor–chymotrypsin complex
Tzuri, N., Kass, I., Orenstein, Y. & Papo, N., 1 Jul 2026, In: Protein Science. 35, 7, e70660.
Research output: Contribution to journal › Article › peer-review

Open Access
Modifying inhibitor specificity for homologous enzymes by machine learning
Gozlan, D. S., Meiri, R., Shapira, G., Coban, M., Radisky, E. S., Orenstein, Y. & Papo, N., 1 Feb 2026, In: FEBS Journal. 293, 4, p. 1007-1023 17 p.
Research output: Contribution to journal › Article › peer-review

Open Access
PRSS23 promotes ovarian cancer peritoneal dissemination independent of protease activity
Akhtar, S., Coban, M., Miller, E., Hockla, A., Maina, E., Mehner, C., Ilic, S., Papo, N., Radisky, D. C. & Radisky, E. S., 1 Jun 2026, In: Journal of Biological Chemistry. 302, 6, 111450.
Research output: Contribution to journal › Article › peer-review

Open Access
Mapping the sclerostin–LRP4 binding interface identifies critical interaction hotspots in loops 1 and 3 of sclerostin
Katchkovsky, S., Meiri, R., Lacham-Hartman, S., Orenstein, Y., Levaot, N. & Papo, N., 1 Feb 2025, In: FEBS Letters. 599, 3, p. 316-329 14 p.
Research output: Contribution to journal › Article › peer-review

Open Access
1 Scopus citations
Neuroprotective functions of the APPI domain of amyloid precursor protein (APP): Reducing KLK6-mediated APP cleavage and Aβ42 formation and aggregation
Lacham-Hartman, S., Oren, O., Rabinovitch, M. & Papo, N., 1 Aug 2025, In: International Journal of Biological Macromolecules. 320, 146066.
Research output: Contribution to journal › Article › peer-review

Open Access
2 Scopus citations
Structural analysis of nanobody interactions with their prostate-specific membrane antigen binding epitopes
Alon-Zchut, G., Zalk, R., Huynh, T. T., Zalutsky, M. R., Weizmann, Y., Zarivach, R. & Papo, N., 1 Aug 2025, In: International Journal of Biological Macromolecules. 320, 145693.
Research output: Contribution to journal › Article › peer-review

Open Access
3 Scopus citations
Deep neural networks for predicting the affinity landscape of protein-protein interactions
Meiri, R., Aharoni Lotati, S. L., Orenstein, Y. & Papo, N., 20 Sep 2024, In: iScience. 27, 9, 110772.
Research output: Contribution to journal › Article › peer-review

Open Access
3 Scopus citations
Preventing osteoporotic bone loss in mice by promoting balanced bone remodeling through M-CSF_RGD, a dual antagonist to c-FMS and αvβ3 receptors
Zur, Y., Katchkovsky, S., Itzhar, A., Abramovitch-Dahan, C. V., Stepensky, D., Papo, N. & Levaot, N., 1 Dec 2024, In: International Journal of Biological Macromolecules. 282, 136821.
Research output: Contribution to journal › Article › peer-review

Open Access
2 Scopus citations
PSMA-reactive NB7 single domain antibody fragment: A potential scaffold for developing prostate cancer theranostics
Huynh, T. T., Feng, Y., Meshaw, R., Zhao, X. G., Rosenfeld, L., Vaidyanathan, G., Papo, N. & Zalutsky, M. R., 1 Jul 2024, In: Nuclear Medicine and Biology. 134-135, 108913.
Research output: Contribution to journal › Article › peer-review
9 Scopus citations
APPI-Derived Cyclic Peptide Enhances Aβ42 Aggregation and Reduces Aβ42-Mediated Membrane Destabilization and Cytotoxicity
Lacham-Hartman, S., Moshe, R., Ben-Zichri, S., Shmidov, Y., Bitton, R., Jelinek, R. & Papo, N., 20 Sep 2023, In: ACS Chemical Neuroscience. 14, 18, p. 3385-3397 13 p.
Research output: Contribution to journal › Article › peer-review
7 Scopus citations

8 Active
12 Finished

Diagnosis and treatment of metastatic cancers using a Kunitz domain that selectively targets mesotrypsin
Papo, N. (PI)
Israel Science Foundation
1/01/24 → 31/12/27
Project: Research
Map Ligand Binding Selectivity Landscapes toward Engineering Target-Specific Inhibitors
Papo, N. (PI)
Israel Cancer Research Fund
1/01/21 → …
Project: Research
Targeting novel protease PRSS23 to inhibit ovarian cancer progression
Papo, N. (PI) & Radisky, E. E. (CoPI)
United States-Israel Binational Science Foundation (BSF)
1/01/19 → …
Project: Research
Targeting novel protease PRSS23 to inhibit ovarian cancer progression
Papo, N. (PI) & Radisky, E. E. (CoPI)
1/01/19 → …
Project: Research
Usage of INCPM platform on ISF research grant No.615/14 - Utilizing combinatorial methods to develop bi-specific peptide-small molecule conjugates for applications in cancer imaging and therapy
Papo, N. (PI)
Israel Science Foundation
1/01/16 → …
Project: Research
Protein engineering lab
Papo, N. (PI), Aharoni, A.-M. (CoPI) & Gazit, R. (CoPI)
Israel Science Foundation
1/01/14 → …
Project: Research
Cenntrifuge, FPLC, freezer, incubator shaker CO2, bench-top centrifuge, electroporation system, spectrophotometer, incubator shakers, water purification system, imaging system
Papo, N. (PI)
Israel Science Foundation
1/01/14 → …
Project: Research
Developing novel dual-specific proteins that target multiple receptors for applications in prostate cancer imaging and therapy
Papo, N. (PI)
Prostate Cancer Foundation
1/01/13 → …
Project: Research
Map Ligand Binding Selectivity Landscapes toward Engineering Target-Specific Inhibitors
Papo, N. (PI)
Israel Cancer Research Fund
1/01/23 → 31/12/24
Project: Research
Map Ligand Binding Selectivity Landscapes toward Engineering Target-Specific Inhibitors
Papo, N. (PI)
Israel Cancer Research Fund
1/01/22 → 31/12/23
Project: Research

Niv Papo

Personal profile

Fingerprint

Collaborations and top research areas from the last five years

Dive into details

Machine-learning prediction of affinity and epistasis in the bovine pancreatic trypsin inhibitor–chymotrypsin complex

Modifying inhibitor specificity for homologous enzymes by machine learning

PRSS23 promotes ovarian cancer peritoneal dissemination independent of protease activity

Mapping the sclerostin–LRP4 binding interface identifies critical interaction hotspots in loops 1 and 3 of sclerostin

Neuroprotective functions of the APPI domain of amyloid precursor protein (APP): Reducing KLK6-mediated APP cleavage and Aβ42 formation and aggregation

Structural analysis of nanobody interactions with their prostate-specific membrane antigen binding epitopes

Deep neural networks for predicting the affinity landscape of protein-protein interactions

Preventing osteoporotic bone loss in mice by promoting balanced bone remodeling through M-CSF_RGD, a dual antagonist to c-FMS and αvβ3 receptors

PSMA-reactive NB7 single domain antibody fragment: A potential scaffold for developing prostate cancer theranostics

APPI-Derived Cyclic Peptide Enhances Aβ42 Aggregation and Reduces Aβ42-Mediated Membrane Destabilization and Cytotoxicity

Diagnosis and treatment of metastatic cancers using a Kunitz domain that selectively targets mesotrypsin

Map Ligand Binding Selectivity Landscapes toward Engineering Target-Specific Inhibitors

Targeting novel protease PRSS23 to inhibit ovarian cancer progression

Targeting novel protease PRSS23 to inhibit ovarian cancer progression

Usage of INCPM platform on ISF research grant No.615/14 - Utilizing combinatorial methods to develop bi-specific peptide-small molecule conjugates for applications in cancer imaging and therapy

Protein engineering lab

Cenntrifuge, FPLC, freezer, incubator shaker CO2, bench-top centrifuge, electroporation system, spectrophotometer, incubator shakers, water purification system, imaging system

Developing novel dual-specific proteins that target multiple receptors for applications in prostate cancer imaging and therapy

Map Ligand Binding Selectivity Landscapes toward Engineering Target-Specific Inhibitors

Map Ligand Binding Selectivity Landscapes toward Engineering Target-Specific Inhibitors

Niv Papo

Personal profile

Fingerprint

Collaborations and top research areas from the last five years

Research output

Projects