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Collaborations and top research areas from the last five years
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Orphan drug uttroside B impedes MASH progression and HCC development in experimental models
Rayginia, T. P., Keerthana, C. K., Aiswarya, S. U., Shifana, S. C., Jannet, S., Varma, S. S., Maria Joy, P., Swetha, M., James, S., Aparna, J. S., Vijayan, Y., Retnakumary, A. P., Nath, L. R., Kalimuthu, K., Jaikumar, V. S., Sundaram, S., Anto, N. P., Isakov, N., Harikumar, K. B. & Lankalapalli, R. S. & 1 others, , 1 Feb 2026, In: JHEP Reports. 8, 2, 101626.Research output: Contribution to journal › Article › peer-review
Open Access -
The peptidyl-prolyl cis-trans isomerase, Pin1, is a regulator of the protein kinase C θ (PKCθ) catalytic activity in activated T cells
Anto, N. P., Muraleedharan, A., Jayaram, D. R., Liju, V. B., Shaik, J., Malter, J., Keasar, C., Livneh, E., Braiman, A., Altman, A., Kong, K. F. & Isakov, N., 1 Jan 2026, In: Protein Science. 35, 1, e70414.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Uttroside B, a US FDA-designated ‘Orphan Drug’, mitigates the development of hepatocellular carcinoma and its pulmonary metastasis via EGFR/ERK-mediated inhibition of SREBP-1 and STAT-3
Keerthana, C. K., Rayginia, T. P., Kalimuthu, K., Saha, S., Haritha, N. H., Nisthul Areekkara, A., Swetha, M., Aiswarya, S. U., Nath, L. R., Varma, S. S., Viswanathan, A., S, J., J, S., JS, A., Praveen, A., Jaikumar, V. S., Sundaram, S., Anto, N. P., Maiti, T. K. & Sadasivan, C. & 4 others, , 1 Dec 2026, In: Cell Death Discovery. 12, 1, 250.Research output: Contribution to journal › Article › peer-review
Open Access -
Mechanisms of Cbl-Mediated Ubiquitination of Proteins in T and Natural Killer Cells and Effects on Immune Cell Functions
Nath, P. R. & Isakov, N., 1 Dec 2024, In: Life. 14, 12, 1592.Research output: Contribution to journal › Review article › peer-review
Open Access2 Scopus citations -
Conformational and functional regulation of the chicken tumor virus number 10 (CT10) regulator of kinase II (CrkII) adaptor protein by cyclophilin A
Isakov, N., 1 Jan 2023, In: Exploration of Immunology. 3, 3, p. 217-232 16 p.Research output: Contribution to journal › Review article › peer-review
Open Access -
Cyclophilin A associates with and regulates the activity of ZAP70 in TCR/CD3-stimulated T cells
Anto, N. P., Arya, A. K., Muraleedharan, A., Shaik, J., Nath, P. R., Livneh, E., Sun, Z., Braiman, A. & Isakov, N., 1 Jan 2023, In: Cellular and Molecular Life Sciences. 80, 1, 7.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
Termination of TCR-mediated activation signals is regulated by CrkII-dependent Cbl-mediated ubiquitination and degradation of C3G
Nath, P. R., Anto, N. P., Braiman, A. & Isakov, N., 1 Mar 2023, In: Immunobiology. 228, 2, 152342.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
The Peptidyl-Prolyl cis-trans isomerase, Pin1, associates with Protein Kinase C θ via a critical Phospho-Thr-Pro motif in the V3 regulatory domain
Anto, N. P., Muraleedharan, A., Nath, P. R., Sun, Z., Keasar, C., Livneh, E., Braiman, A., Altman, A., Kong, K. F. & Isakov, N., 1 Jan 2023, In: Frontiers in Immunology. 14, 1126464.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
The role of AMPK in cancer metabolism and its impact on the immunomodulation of the tumor microenvironment
Keerthana, C. K., Rayginia, T. P., Shifana, S. C., Anto, N. P., Kalimuthu, K., Isakov, N. & Anto, R. J., 1 Jan 2023, In: Frontiers in Immunology. 14, 1114582.Research output: Contribution to journal › Review article › peer-review
Open Access154 Scopus citations -
Augmented Efficacy of Uttroside B over Sorafenib in a Murine Model of Human Hepatocellular Carcinoma
Swetha, M., Keerthana, C. K., Rayginia, T. P., Nath, L. R., Haritha, N. H., Shabna, A., Kalimuthu, K., Thangarasu, A. K., Aiswarya, S. U., Jannet, S., Pillai, S., Harikumar, K. B., Sundaram, S., Anto, N. P., Wu, D. H., Lankalapalli, R. S., Towner, R., Isakov, N., Deepa, S. S. & Anto, R. J., 1 May 2022, In: Pharmaceuticals. 15, 5, 636.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations
Press/Media
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Recent Findings from Ben-Gurion University of the Negev Provide New Insights into Phosphotransferases (Alcohol Group Acceptor) [The peptidyl-prolyl cis-trans isomerase, Pin1, is a regulator of the protein kinase C th (PKCth) catalytic activity ...]
Livneh, E., Isakov, N., Keasar, C. & Braiman, A.
7/01/26
1 item of Media coverage
Press/Media
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Molecular and cellular analysis of PKC-theta mediated regulation of T cell functions
Isakov, N. (PI) & Altman, A. A. (CoPI)
United States-Israel Binational Science Foundation (BSF)
1/01/07 → …
Project: Research
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Molecular and cellular analysis of PKC-theta mediated regulation of T cell functions
Isakov, N. (PI) & Altman, A. A. (CoPI)
1/01/07 → …
Project: Research
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Flow cytometer for multicolor analysis of cells / particles
Porgador, A. (PI), Apte, R. (CoPI) & Isakov, N. (CoPI)
1/01/06 → …
Project: Research
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PICOT Mediated Regulation of T Lymphocyte Functions
Isakov, N. (PI) & Altman, A. A. (CoPI)
United States-Israel Binational Science Foundation (BSF)
1/01/03 → …
Project: Research
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PICOT Mediated Regulation of T Lymphocyte Functions
Isakov, N. (PI) & Altman, A. A. (CoPI)
United States-Israel Binational Science Foundation (BSF)
1/01/03 → …
Project: Research
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Functional Role of PICOT and PICOT-Homology Domain in T Cell Activation
Isakov, N. (PI) & Altman, A. A. (CoPI)
United States-Israel Binational Science Foundation (BSF)
1/01/99 → …
Project: Research
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Functional Role of PICOT and PICOT-Homology Domain in T Cell Activation
Isakov, N. (PI) & Altman, A. A. (CoPI)
United States-Israel Binational Science Foundation (BSF)
1/01/99 → …
Project: Research
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Regulation of PKC in T Lymphocytes by 14-3-3 and OtherEffector Molecules
Isakov, N. (PI) & Altman, A. A. (CoPI)
1/01/96 → …
Project: Research
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Regulation of PKC in T Lymphocytes by 14-3-3 and OtherEffector Molecules
Isakov, N. (PI) & Altman, A. A. (CoPI)
United States-Israel Binational Science Foundation (BSF)
1/01/96 → …
Project: Research