Ofir Cohen

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Ofir Cohen

 https://orcid.org/0000-0002-0043-6838
20082023

Research activity per year

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Research interests

Computational Oncology & Cancer Genomics

Medical Informatics, Machine Learning, and Artificial Intelligence

Molecular Evolution, Tumor Evolution, and Evolved Drug-Resistance

High-throughput Functional genomics

Metastatic Breast Cancer (MBC)

 

 

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Collaborations and top research areas from the last five years

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  • Functional binding of PD1 ligands predicts response to anti-PD1 treatment in patients with cancer

    Kaufman, B., Abramov, O., Ievko, A., Apple, D., Shlapobersky, M., Allon, I., Greenshpan, Y., Bhattachrya, B., Cohen, O., Charkovsky, T., Gayster, A., Shaco-Levy, R., Rouvinov, K., Livoff, A., Elkabets, M. & Porgador, A., 26 May 2023, In: Science advances. 9, 21, p. eadg2809 eadg2809.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • High FOXA1 levels induce ER transcriptional reprogramming, a pro-metastatic secretome, and metastasis in endocrine-resistant breast cancer

    Fu, X., Pereira, R., Liu, C. C., De Angelis, C., Shea, M. J., Nanda, S., Qin, L., Mitchell, T., Cataldo, M. L., Veeraraghavan, J., Sethunath, V., Giuliano, M., Gutierrez, C., Győrffy, B., Trivedi, M. V., Cohen, O., Wagle, N., Nardone, A., Jeselsohn, R., Rimawi, M. F., & 2 othersOsborne, C. K. & Schiff, R., 29 Aug 2023, In: Cell Reports. 42, 8, 112821.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Mutated HRAS Activates YAP1–AXL Signaling to Drive Metastasis of Head and Neck Cancer

    Jagadeeshan, S., Prasad, M., Badarni, M., Ben-Lulu, T., Liju, V. B., Mathukkada, S., Saunders, C., Shnerb, A. B., Zorea, J., Yegodayev, K. M., Wainer, M., Vtorov, L., Allon, I., Cohen, O., Gausdal, G., Friedmann-Morvinski, D., Cheong, S. C., Ho, A. L., Rosenberg, A. J., Kessler, L., & 5 othersBurrows, F., Kong, D., Grandis, J. R., Silvio Gutkind, J. & Elkabets, M., 1 Apr 2023, In: Cancer Research. 83, 7, p. 1031-1047 17 p.

    Research output: Contribution to journal › Article › peer-review

    5 Scopus citations

  • ESR1 mutant breast cancers show elevated basal cytokeratins and immune activation

    Li, Z., McGinn, O., Wu, Y., Bahreini, A., Priedigkeit, N. M., Ding, K., Onkar, S., Lampenfeld, C., Sartorius, C. A., Miller, L., Rosenzweig, M., Cohen, O., Wagle, N., Richer, J. K., Muller, W. J., Buluwela, L., Ali, S., Bruno, T. C., Vignali, D. A. A., Fang, Y., & 6 othersZhu, L., Tseng, G. C., Gertz, J., Atkinson, J. M., Lee, A. V. & Oesterreich, S., 1 Dec 2022, In: Nature Communications. 13, 1, 2011.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    18 Scopus citations

  • MITI minimum information guidelines for highly multiplexed tissue images

    Human Tumor Atlas Network, 1 Mar 2022, In: Nature Methods. 19, 3, p. 262-267 6 p.

    Research output: Contribution to journal › Comment/debate

    Open Access
    19 Scopus citations

  • Opposing immune and genetic mechanisms shape oncogenic programs in synovial sarcoma

    Jerby-Arnon, L., Neftel, C., Shore, M. E., Weisman, H. R., Mathewson, N. D., McBride, M. J., Haas, B., Izar, B., Volorio, A., Boulay, G., Cironi, L., Richman, A. R., Broye, L. C., Gurski, J. M., Luo, C. C., Mylvaganam, R., Nguyen, L., Mei, S., Melms, J. C., Georgescu, C., & 30 othersCohen, O., Buendia-Buendia, J. E., Segerstolpe, A., Sud, M., Cuoco, M. S., Labes, D., Gritsch, S., Zollinger, D. R., Ortogero, N., Beechem, J. M., Petur Nielsen, G., Chebib, I., Nguyen-Ngoc, T., Montemurro, M., Cote, G. M., Choy, E., Letovanec, I., Cherix, S., Wagle, N., Sorger, P. K., Haynes, A. B., Mullen, J. T., Stamenkovic, I., Rivera, M. N., Kadoch, C., Wucherpfennig, K. W., Rozenblatt-Rosen, O., Suvà, M. L., Riggi, N. & Regev, A., 1 Feb 2021, In: Nature Medicine. 27, 2, p. 289-300 12 p.

    Research output: Contribution to journal › Article › peer-review

    48 Scopus citations

  • Spatially organized multicellular immune hubs in human colorectal cancer

    Pelka, K., Hofree, M., Chen, J. H., Sarkizova, S., Pirl, J. D., Jorgji, V., Bejnood, A., Dionne, D., Ge, W. H., Xu, K. H., Chao, S. X., Zollinger, D. R., Lieb, D. J., Reeves, J. W., Fuhrman, C. A., Hoang, M. L., Delorey, T., Nguyen, L. T., Waldman, J., Klapholz, M., & 52 othersWakiro, I., Cohen, O., Albers, J., Smillie, C. S., Cuoco, M. S., Wu, J., Su, M. J., Yeung, J., Vijaykumar, B., Magnuson, A. M., Asinovski, N., Moll, T., Goder-Reiser, M. N., Applebaum, A. S., Brais, L. K., DelloStritto, L. K., Denning, S. L., Phillips, S. T., Hill, E. K., Meehan, J. K., Frederick, D. T., Sharova, T., Kanodia, A., Todres, E. Z., Jané-Valbuena, J., Biton, M., Izar, B., Lambden, C. D., Clancy, T. E., Bleday, R., Melnitchouk, N., Irani, J., Kunitake, H., Berger, D. L., Srivastava, A., Hornick, J. L., Ogino, S., Rotem, A., Vigneau, S., Johnson, B. E., Corcoran, R. B., Sharpe, A. H., Kuchroo, V. K., Ng, K., Giannakis, M., Nieman, L. T., Boland, G. M., Aguirre, A. J., Anderson, A. C., Rozenblatt-Rosen, O., Regev, A. & Hacohen, N., 2 Sep 2021, In: Cell. 184, 18, p. 4734-4752.e20

    Research output: Contribution to journal › Article › peer-review

    Open Access
    137 Scopus citations

  • Acquired FGFR and FGF alterations confer resistance to Estrogen Receptor (ER) targeted therapy in ERþ metastatic breast cancer

    Mao, P., Cohen, O., Kowalski, K. J., Kusiel, J. G., Buendia-Buendia, J. E., Cuoco, M. S., Exman, P., Wander, S. A., Waks, A. G., Nayar, U., Chung, J., Freeman, S., Rozenblatt-Rosen, O., Miller, V. A., Piccioni, F., Root, D. E., Regev, A., Winer, E. P., Lin, N. U. & Wagle, N., 15 Nov 2020, In: Clinical Cancer Research. 26, 22, p. 5974-5989 16 p.

    Research output: Contribution to journal › Article › peer-review

    63 Scopus citations

  • A single-cell and single-nucleus RNA-Seq toolbox for fresh and frozen human tumors

    Slyper, M., Porter, C. B. M., Ashenberg, O., Waldman, J., Drokhlyansky, E., Wakiro, I., Smillie, C., Smith-Rosario, G., Wu, J., Dionne, D., Vigneau, S., Jané-Valbuena, J., Tickle, T. L., Napolitano, S., Su, M. J., Patel, A. G., Karlstrom, A., Gritsch, S., Nomura, M., Waghray, A., & 30 othersGohil, S. H., Tsankov, A. M., Jerby-Arnon, L., Cohen, O., Klughammer, J., Rosen, Y., Gould, J., Nguyen, L., Hofree, M., Tramontozzi, P. J., Li, B., Wu, C. J., Izar, B., Haq, R., Hodi, F. S., Yoon, C. H., Hata, A. N., Baker, S. J., Suvà, M. L., Bueno, R., Stover, E. H., Clay, M. R., Dyer, M. A., Collins, N. B., Matulonis, U. A., Wagle, N., Johnson, B. E., Rotem, A., Rozenblatt-Rosen, O. & Regev, A., May 2020, In: Nature Medicine. 26, 5, p. 792-802 11 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    237 Scopus citations

  • Author Correction: A single-cell and single-nucleus RNA-Seq toolbox for fresh and frozen human tumors (Nature Medicine, (2020), 26, 5, (792-802), 10.1038/s41591-020-0844-1)

    Slyper, M., Porter, C. B. M., Ashenberg, O., Waldman, J., Drokhlyansky, E., Wakiro, I., Smillie, C., Smith-Rosario, G., Wu, J., Dionne, D., Vigneau, S., Jané-Valbuena, J., Tickle, T. L., Napolitano, S., Su, M. J., Patel, A. G., Karlstrom, A., Gritsch, S., Nomura, M., Waghray, A., & 30 othersGohil, S. H., Tsankov, A. M., Jerby-Arnon, L., Cohen, O., Klughammer, J., Rosen, Y., Gould, J., Nguyen, L., Hofree, M., Tramontozzi, P. J., Li, B., Wu, C. J., Izar, B., Haq, R., Hodi, F. S., Yoon, C. H., Hata, A. N., Baker, S. J., Suvà, M. L., Bueno, R., Stover, E. H., Clay, M. R., Dyer, M. A., Collins, N. B., Matulonis, U. A., Wagle, N., Johnson, B. E., Rotem, A., Rozenblatt-Rosen, O. & Regev, A., 1 Aug 2020, In: Nature Medicine. 26, 8, p. 1307 1 p.

    Research output: Contribution to journal › Comment/debate

    Open Access
    8 Scopus citations
View all 43 Research outputs