Personal profile
Research interests
Computational Oncology & Cancer Genomics
Medical Informatics, Machine Learning, and Artificial Intelligence
Molecular Evolution, Tumor Evolution, and Evolved Drug-Resistance
High-throughput Functional genomics
Metastatic Breast Cancer (MBC)
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Aging-associated differences in mammary tumor–initiating populations and immune evasion pathways in breast cancer
Yan, P., Bui, T., Jimenez, E. R., Kuang, Y., Xu, S., Paweletz, C. P., Haimov, H., Sklartz, M., Cohen, O., McAllister, S. S. & Polyak, K., 24 Feb 2026, In: Proceedings of the National Academy of Sciences of the United States of America. 123, 8, e2523254123.Research output: Contribution to journal › Article › peer-review
Open Access -
PKC-eta promotes breast cancer metastasis by regulating the Hippo–YAP signaling pathway
Liju, V. B., Waidha, K., Muraleedharan, A., Jayaram, D. R., Haimov, H., Jagadeeshan, S., Manikandan, D. B., Shareb, R. A., Nurukurti, L., Sklarz, M., Gutkind, J. S., Allon, I., Cohen, O., Elkabets, M. & Livneh, E., 1 Dec 2026, In: Signal Transduction and Targeted Therapy. 11, 1, 58.Research output: Contribution to journal › Article › peer-review
Open Access -
Author Correction: A multi-modal single-cell and spatial expression map of metastatic breast cancer biopsies across clinicopathological features (Nature Medicine, (2024), 30, 11, (3236-3249), 10.1038/s41591-024-03215-z)
Klughammer, J., Abravanel, D. L., Segerstolpe, Å., Blosser, T. R., Goltsev, Y., Cui, Y., Goodwin, D. R., Sinha, A., Ashenberg, O., Slyper, M., Vigneau, S., Jané‐Valbuena, J., Alon, S., Caraccio, C., Chen, J., Cohen, O., Cullen, N., DelloStritto, L. K., Dionne, D. & Files, J. & 39 others, , 1 May 2025, In: Nature Medicine. 31, 5, p. 1713 1 p.Research output: Contribution to journal › Comment/debate
Open Access -
Mechanostimulatory Platform for Improved CAR T Cell Immunotherapy
Yassin, A. A. K., Ureña Martin, C., Le Saux, G., Pandey, A., Tzadka, S., Toledo, E., Pandit, J. J., Sherf, T., Nusbaum, I., Bhattachrya, B., Banerji, R., Greenshpan, Y., Abu Ahmad, M. A., Radinsky, O., Sklartz, M., Gazit, R., Elkabets, M., Ghassemi, S., Cohen, O. & Schvartzman, M. & 1 others, , 24 Jul 2025, In: Advanced Materials. 37, 29, 2412482.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Pharmacological activation of SIRT6 suppresses progression of head and neck and esophageal squamous cell carcinoma by modulation of cellular metabolism and protein translation
Ben Lulu, T., Manikandan, D. B., Pevzner, Y., Sklarz, M., Eisdorfer, S. A., Awad, S., Mathukkada, S., Marripati, D., Wainer, M., Shimshilashvili-Kleiner, L., Ohana, E., Cohen, I., Zhang, J., Alassam, S. S., Rotblat, B., Wang, H., Kong, D., Cohen, O., Toiber, D. & Elkabets, M., 1 Dec 2025, In: Cell Death and Disease. 16, 1, 727.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
SlideCNA: spatial copy number alteration detection from Slide-seq-like spatial transcriptomics data
Zhang, D., Segerstolpe, Å., Slyper, M., Waldman, J., Murray, E., Strasser, R., Watter, J., Cohen, O., Ashenberg, O., Abravanel, D., Jané-Valbuena, J., Mages, S., Lako, A., Helvie, K., Rozenblatt-Rosen, O., Rodig, S., Chen, F., Wagle, N., Regev, A. & Klughammer, J., 1 Dec 2025, In: Genome Biology. 26, 1, 112.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
A multi-modal single-cell and spatial expression map of metastatic breast cancer biopsies across clinicopathological features
Klughammer, J., Abravanel, D. L., Segerstolpe, Å., Blosser, T. R., Goltsev, Y., Cui, Y., Goodwin, D. R., Sinha, A., Ashenberg, O., Slyper, M., Vigneau, S., Jané‐Valbuena, J., Alon, S., Caraccio, C., Chen, J., Cohen, O., Cullen, N., DelloStritto, L. K., Dionne, D. & Files, J. & 39 others, , 1 Nov 2024, In: Nature Medicine. 30, 11, p. 3236-3249 14 p.Research output: Contribution to journal › Article › peer-review
Open Access35 Scopus citations -
Correction to: Subclonal cooperation drives metastasis by modulating local and systemic immune microenvironments (Nature Cell Biology, (2019), 21, 7, (879-888), 10.1038/s41556-019-0346-x)
Janiszewska, M., Tabassum, D. P., Castaño, Z., Cristea, S., Yamamoto, K. N., Kingston, N. L., Murphy, K. C., Shu, S., Harper, N. W., Del Alcazar, C. G., Alečković, M., Ekram, M. B., Cohen, O., Kwak, M., Qin, Y., Laszewski, T., Luoma, A., Marusyk, A., Wucherpfennig, K. W. & Wagle, N. & 4 others, , 1 May 2024, In: Nature Cell Biology. 26, 5, p. 841 1 p.Research output: Contribution to journal › Comment/debate
Open Access -
Elucidating the Transcriptional States of Spermatogenesis—Joint Analysis of Germline and Supporting Cell, Mice and Human, Normal and Perturbed, Bulk and Single-Cell RNA-Seq
AbuMadighem, A., Cohen, O. & Huleihel, M., 1 Jul 2024, In: Biomolecules. 14, 7, 840.Research output: Contribution to journal › Review article › peer-review
Open Access2 Scopus citations -
PD1 ligand functionality a biomarker of response to anti PD1 treatment in patients with HNSCC
Kaufman, B., Taha, T., Abramov, O., Zohar, Y., Mhameed, K., Cohen, O., Porgador, A., Elkabets, M. & Billan, S., 1 Dec 2024, In: npj Precision Oncology. 8, 1, 126.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations
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Uncovering potential modulation of age-related transcriptional states in tumors and their microenvironment in clinical metastatic breast cancer
Berthelote, A. R. (PI), Cohen, O. (PI) & Polyak, K. (CoPI)
United States-Israel Binational Science Foundation (BSF)
1/09/20 → 31/08/24
Project: Research