Research output per year
Research output per year
Personal profile
Research interests
In collaboration with colleagues from the Health Sciences Faculty, I am investigating the long-term effects of neurotoxic levels of glutamate following brain injury on the development of depression, anxiety, social behaviour changes, such as submissive or aggressive behaviour in rat models of brain trauma. Novel methods of altering the balance between brain and blood glucose after injury are potential prevention strategies tested in rats in order to minimize the development of post-injury psychiatric pathologies.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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Loss of the zinc receptor ZnR/GPR39 in mice enhances anxiety-related behavior and motor deficits, and modulates KCC2 expression in the amygdala
Sagi, R., Chakraborty, M., Bogdanovic, M., Asraf, H., Sekler, I., Kofman, O., Cohen, H. & Hershfinkel, M., 1 Dec 2024, In: Behavioral and Brain Functions. 20, 1, 31.Research output: Contribution to journal › Article › peer-review
Open Access -
Blood glutamate scavenging as a novel glutamate-based therapeutic approach for post-traumatic brain injury anxiety and social impairment
Frank, D., Gruenbaum, B. F., Shelef, I., Zvenigorodsky, V., Severynovska, O., Fleidervish, I., Knyazer, B., Frenkel, A., Zlotnik, A., Kofman, O. & Boyko, M., 1 Dec 2023, In: Translational Psychiatry. 13, 1, 41.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
Temporal dynamics of isolation calls emitted by pups in environmental and genetic mouse models of autism spectrum disorder
Gal, A., Raykin, E., Giladi, S., Lederman, D., Kofman, O. & Golan, H. M., 23 Oct 2023, In: Frontiers in Neuroscience. 17, 1274039.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
The Integrity of the Blood–Brain Barrier as a Critical Factor for Regulating Glutamate Levels in Traumatic Brain Injury
Boyko, M., Gruenbaum, B. F., Frank, D., Natanel, D., Negev, S., Azab, A. N., Barsky, G., Knyazer, B., Kofman, O. & Zlotnik, A., 1 Mar 2023, In: International Journal of Molecular Sciences. 24, 6, 5897.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
Blood Glutamate Scavenging With Pyruvate as a Novel Preventative and Therapeutic Approach for Depressive-Like Behavior Following Traumatic Brain Injury in a Rat Model
Frank, D., Gruenbaum, B. F., Shelef, I., Zvenigorodsky, V., Severynovska, O., Gal, R., Dubilet, M., Zlotnik, A., Kofman, O. & Boyko, M., 14 Feb 2022, In: Frontiers in Neuroscience. 16, 832478.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
Essential role of the mitochondrial Na+/Ca2+ exchanger NCLX in mediating PDE2-dependent neuronal survival and learning
Rozenfeld, M., Azoulay, I. S., Ben Kasus Nissim, T., Stavsky, A., Melamed, M., Stutzmann, G., Hershfinkel, M., Kofman, O. & Sekler, I., 6 Dec 2022, In: Cell Reports. 41, 10, 111772.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations -
Isolation-Induced Ultrasonic Vocalization in Environmental and Genetic Mice Models of Autism
Shekel, I., Giladi, S., Raykin, E., Weiner, M., Chalifa-Caspi, V., Lederman, D., Kofman, O. & Golan, H. M., 22 Nov 2021, In: Frontiers in Neuroscience. 15, 769670.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
Developmental and social deficits and enhanced sensitivity to prenatal chlorpyrifos in PON1-/- mouse pups and adults
Kofman, O., Lan, A., Raykin, E., Zega, K. & Brodski, C., 1 Sep 2020, In: PLoS ONE. 15, 9 September, e0239738.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Early life stress induces submissive behavior in adult rats
Frank, D., Zlotnik, A., Kofman, O., Grinshpun, J., Severynovska, O., Brotfain, E., Kut, R., Natanel, D., Melamed, I. & Boyko, M., 17 Oct 2019, In: Behavioural Brain Research. 372, 112025.Research output: Contribution to journal › Article › peer-review
16 Scopus citations -
Impaired innate and conditioned social behavior in adult C57Bl6/J mice prenatally exposed to chlorpyrifos
Lan, A., Stein, D., Portillo, M., Toiber, D. & Kofman, O., 1 Mar 2019, In: Behavioral and Brain Functions. 15, 1, 2.Research output: Contribution to journal › Article › peer-review
Open Access23 Scopus citations