Research output per year
Research output per year
Personal profile
Research interests
In collaboration with colleagues from the Health Sciences Faculty, I am investigating the long-term effects of neurotoxic levels of glutamate following brain injury on the development of depression, anxiety, social behaviour changes, such as submissive or aggressive behaviour in rat models of brain trauma. Novel methods of altering the balance between brain and blood glucose after injury are potential prevention strategies tested in rats in order to minimize the development of post-injury psychiatric pathologies.
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Collaborations and top research areas from the last five years
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Blood glutamate scavenging as a novel glutamate-based therapeutic approach for post-traumatic brain injury anxiety and social impairment
Frank, D., Gruenbaum, B. F., Shelef, I., Zvenigorodsky, V., Severynovska, O., Fleidervish, I., Knyazer, B., Frenkel, A., Zlotnik, A., Kofman, O. & Boyko, M., 4 Feb 2023, In: Translational Psychiatry. 13, 1, 41.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
The Integrity of the Blood–Brain Barrier as a Critical Factor for Regulating Glutamate Levels in Traumatic Brain Injury
Boyko, M., Gruenbaum, B. F., Frank, D., Natanel, D., Negev, S., Azab, A. N., Barsky, G., Knyazer, B., Kofman, O. & Zlotnik, A., 1 Mar 2023, In: International Journal of Molecular Sciences. 24, 6, 5897.Research output: Contribution to journal › Article › peer-review
Open Access -
Blood Glutamate Scavenging With Pyruvate as a Novel Preventative and Therapeutic Approach for Depressive-Like Behavior Following Traumatic Brain Injury in a Rat Model
Frank, D., Gruenbaum, B. F., Shelef, I., Zvenigorodsky, V., Severynovska, O., Gal, R., Dubilet, M., Zlotnik, A., Kofman, O. & Boyko, M., 14 Feb 2022, In: Frontiers in Neuroscience. 16, 832478.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Essential role of the mitochondrial Na+/Ca2+ exchanger NCLX in mediating PDE2-dependent neuronal survival and learning
Rozenfeld, M., Azoulay, I. S., Ben Kasus Nissim, T., Stavsky, A., Melamed, M., Stutzmann, G., Hershfinkel, M., Kofman, O. & Sekler, I., 6 Dec 2022, In: Cell Reports. 41, 10, 111772.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Isolation-Induced Ultrasonic Vocalization in Environmental and Genetic Mice Models of Autism
Shekel, I., Giladi, S., Raykin, E., Weiner, M., Chalifa-Caspi, V., Lederman, D., Kofman, O. & Golan, H. M., 22 Nov 2021, In: Frontiers in Neuroscience. 15, 769670.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Developmental and social deficits and enhanced sensitivity to prenatal chlorpyrifos in PON1-/- mouse pups and adults
Kofman, O., Lan, A., Raykin, E., Zega, K. & Brodski, C., 1 Sep 2020, In: PLoS ONE. 15, 9 September, e0239738.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Early life stress induces submissive behavior in adult rats
Frank, D., Zlotnik, A., Kofman, O., Grinshpun, J., Severynovska, O., Brotfain, E., Kut, R., Natanel, D., Melamed, I. & Boyko, M., 17 Oct 2019, In: Behavioural Brain Research. 372, 112025.Research output: Contribution to journal › Article › peer-review
13 Scopus citations -
Impaired innate and conditioned social behavior in adult C57Bl6/J mice prenatally exposed to chlorpyrifos
Lan, A., Stein, D., Portillo, M., Toiber, D. & Kofman, O., 1 Mar 2019, In: Behavioral and Brain Functions. 15, 1, 2.Research output: Contribution to journal › Article › peer-review
Open Access20 Scopus citations -
Role of self-criticism in reward and punishment probabilistic learning
Duek, O., Shahar, G., Osher, Y. & Kofman, O., 1 Nov 2018, In: Personality and Individual Differences. 134, p. 155-163 9 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Prenatal chlorpyrifos leads to autism-like deficits in C57Bl6/J mice
Lan, A., Kalimian, M., Amram, B. & Kofman, O., 2 May 2017, In: Environmental Health: A Global Access Science Source. 16, 1, 43.Research output: Contribution to journal › Article › peer-review
Open Access45 Scopus citations