Research output per year
Research output per year
Personal profile
Research interests
- Neuroendocrine-Immune interaction,
- Inflammation,
- Pharmacology
Research Topics
- My research focuses on the mechanisms by which inflammation is modulated, its effects on neuroglia and the manner in which this impacts on neurodegenerative diseases. The research is unique in showing that neuropeptides, powerful regulators of peripheral inflammation, also exert important effect on inflammation in the brain. This raises the possibility of new therapeutic strategies for treatment of neurodegenerative disease featuring anti-inflammatory neuropeptide receptor agonists or antagonists
Major expertise and techniques in the lab
- Primary glial cultures inflammatory mediators’ analysis Immunohistochemistry
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Dive into the research topics where Sigal Fleisher is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Cannabinoids’ Role in Modulating Central and Peripheral Immunity in Neurodegenerative Diseases
Sharon, N., Yarmolinsky, L., Khalfin, B., Fleisher-Berkovich, S. & Ben-Shabat, S., 1 Jun 2024, In: International Journal of Molecular Sciences. 25, 12, 6402.Research output: Contribution to journal › Review article › peer-review
Open Access -
Selected cannabis cultivars modulate glial activation: in vitro and in vivo studies
Fleisher-Berkovich, S., Sharon, N., Ventura, Y., Feinshtein, V., Gorelick, J., Bernstein, N. & Ben-Shabat, S., 1 Dec 2024, In: Journal of Cannabis Research. 6, 1, 25.Research output: Contribution to journal › Article › peer-review
Open Access -
An Emerging Strategy for Neuroinflammation Treatment: Combined Cannabidiol and Angiotensin Receptor Blockers Treatments Effectively Inhibit Glial Nitric Oxide Release
Fleisher-Berkovich, S., Battaglia, V., Baratta, F., Brusa, P., Ventura, Y., Sharon, N., Dahan, A., Collino, M. & Ben-Shabat, S., 1 Nov 2023, In: International Journal of Molecular Sciences. 24, 22, 16254.Research output: Contribution to journal › Article › peer-review
Open Access -
Therapeutic Potential of Phytocannabinoid Cannabigerol for Multiple Sclerosis: Modulation of Microglial Activation In Vitro and In Vivo
Fleisher-Berkovich, S., Ventura, Y., Amoyal, M., Dahan, A., Feinshtein, V., Alfahel, L., Israelson, A., Bernstein, N., Gorelick, J. & Ben-Shabat, S., 1 Feb 2023, In: Biomolecules. 13, 2, 376.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Candesartan ameliorates brain inflammation associated with Alzheimer's disease
Torika, N., Asraf, K., Apte, R. N. & Fleisher-Berkovich, S., 1 Mar 2018, In: CNS Neuroscience and Therapeutics. 24, 3, p. 231-242 12 p.Research output: Contribution to journal › Article › peer-review
Open Access60 Scopus citations -
Microglial activation is modulated by captopril: In vitro and in vivo studies
Asraf, K., Torika, N., Apte, R. N. & Fleisher-Berkovich, S., 1 May 2018, In: Frontiers in Cellular Neuroscience. 12, 116.Research output: Contribution to journal › Article › peer-review
Open Access39 Scopus citations -
Intranasal telmisartan ameliorates brain pathology in five familial Alzheimer's disease mice
Torika, N., Asraf, K., Cohen, H. & Fleisher-Berkovich, S., 1 Aug 2017, In: Brain, Behavior, and Immunity. 64, p. 80-90 11 p.Research output: Contribution to journal › Article › peer-review
37 Scopus citations -
Involvement of the bradykinin B1 Receptor in microglial activation: In vitro and in vivo studies
Asraf, K., Torika, N., Danon, A. & Fleisher-Berkovich, S., 19 Apr 2017, In: Frontiers in Endocrinology. 8, APR, 82.Research output: Contribution to journal › Article › peer-review
Open Access24 Scopus citations -
Angiotensin Converting Enzyme Inhibitors Ameliorate Brain Inflammation Associated with Microglial Activation: Possible Implications for Alzheimer’s Disease
Torika, N., Asraf, K., Roasso, E., Danon, A. & Fleisher-Berkovich, S., 1 Dec 2016, In: Journal of NeuroImmune Pharmacology. 11, 4, p. 774-785 12 p.Research output: Contribution to journal › Article › peer-review
53 Scopus citations -
Differential effect of intranasally administrated kinin B1 and B2 receptor antagonists in Alzheimer's disease mice
Asraf, K., Torika, N., Roasso, E. & Fleisher-Berkovich, S., 1 Apr 2016, In: Biological Chemistry. 397, 4, p. 345-351 7 p.Research output: Contribution to journal › Article › peer-review
8 Scopus citations
Press/Media
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Ben-Gurion University of the Negev Researcher Yields New Study Findings on Neurodegenerative Diseases and Conditions (Cannabinoids' Role in Modulating Central and Peripheral Immunity in Neurodegenerative Diseases)
Sharon, N., Ben-Shabat, S., Sigal, F.-B. & Khalfin, B.
25/06/24
1 item of Media coverage
Press/Media