Research output per year
Research output per year
Personal profile
Research interests
- Neuroendocrine-Immune interaction,
- Inflammation,
- Pharmacology
Research Topics
- My research focuses on the mechanisms by which inflammation is modulated, its effects on neuroglia and the manner in which this impacts on neurodegenerative diseases. The research is unique in showing that neuropeptides, powerful regulators of peripheral inflammation, also exert important effect on inflammation in the brain. This raises the possibility of new therapeutic strategies for treatment of neurodegenerative disease featuring anti-inflammatory neuropeptide receptor agonists or antagonists
Major expertise and techniques in the lab
- Primary glial cultures inflammatory mediators’ analysis Immunohistochemistry
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Dive into the research topics where Sigal Fleisher is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Research output
- 26 Article
-
Candesartan ameliorates brain inflammation associated with Alzheimer's disease
Torika, N., Asraf, K., Apte, R. N. & Fleisher-Berkovich, S., 1 Mar 2018, In: CNS Neuroscience and Therapeutics. 24, 3, p. 231-242 12 p.Research output: Contribution to journal › Article › peer-review
Open Access38 Scopus citations -
Microglial activation is modulated by captopril: In vitro and in vivo studies
Asraf, K., Torika, N., Apte, R. N. & Fleisher-Berkovich, S., 1 May 2018, In: Frontiers in Cellular Neuroscience. 12, 116.Research output: Contribution to journal › Article › peer-review
Open Access25 Scopus citations -
Intranasal telmisartan ameliorates brain pathology in five familial Alzheimer's disease mice
Torika, N., Asraf, K., Cohen, H. & Fleisher-Berkovich, S., 1 Aug 2017, In: Brain, Behavior, and Immunity. 64, p. 80-90 11 p.Research output: Contribution to journal › Article › peer-review
24 Scopus citations -
Involvement of the bradykinin B1 Receptor in microglial activation: In vitro and in vivo studies
Asraf, K., Torika, N., Danon, A. & Fleisher-Berkovich, S., 19 Apr 2017, In: Frontiers in Endocrinology. 8, APR, 82.Research output: Contribution to journal › Article › peer-review
Open Access17 Scopus citations -
Angiotensin Converting Enzyme Inhibitors Ameliorate Brain Inflammation Associated with Microglial Activation: Possible Implications for Alzheimer’s Disease
Torika, N., Asraf, K., Roasso, E., Danon, A. & Fleisher-Berkovich, S., 1 Dec 2016, In: Journal of NeuroImmune Pharmacology. 11, 4, p. 774-785 12 p.Research output: Contribution to journal › Article › peer-review
35 Scopus citations -
Differential effect of intranasally administrated kinin B1 and B2 receptor antagonists in Alzheimer's disease mice
Asraf, K., Torika, N., Roasso, E. & Fleisher-Berkovich, S., 1 Apr 2016, In: Biological Chemistry. 397, 4, p. 345-351 7 p.Research output: Contribution to journal › Article › peer-review
8 Scopus citations -
Telmisartan modulates glial activation: In vitro and in vivo studies
Torika, N., Asraf, K., Danon, A., Apte, R. N. & Fleisher-Berkovich, S., 1 May 2016, In: PLoS ONE. 11, 5, e0155823.Research output: Contribution to journal › Article › peer-review
Open Access38 Scopus citations -
Differential regulation of astrocyte prostaglandin response by kinins: Possible role for mitogen activated protein kinases
Torika, N., Filipovich-Rimon, T., Asraf, K., Roasso, E., Danon, A. & Fleisher-Berkovich, S., 21 Aug 2014, In: European Journal of Pharmacology. 741, p. 323-329 7 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Bradykinin decreases nitric oxide release from microglia via inhibition of cyclic adenosine monophosphate signaling
Ben-Shmuel, S., Danon, A. & Fleisher-Berkovich, S., 1 Feb 2013, In: Peptides. 40, p. 133-140 8 p.Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
Distinct modulation of microglial amyloid β phagocytosis and migration by neuropeptidesi
Fleisher-Berkovich, S., Filipovich-Rimon, T., Ben-Shmuel, S., Hülsmann, C., Kummer, M. P. & Heneka, M. T., 11 Oct 2010, In: Journal of Neuroinflammation. 7, 61.Research output: Contribution to journal › Article › peer-review
Open Access57 Scopus citations