Research output per year
Research output per year
Personal profile
Research interests
- Neuroendocrine-Immune interaction,
- Inflammation,
- Pharmacology
Research Topics
- My research focuses on the mechanisms by which inflammation is modulated, its effects on neuroglia and the manner in which this impacts on neurodegenerative diseases. The research is unique in showing that neuropeptides, powerful regulators of peripheral inflammation, also exert important effect on inflammation in the brain. This raises the possibility of new therapeutic strategies for treatment of neurodegenerative disease featuring anti-inflammatory neuropeptide receptor agonists or antagonists
Major expertise and techniques in the lab
- Primary glial cultures inflammatory mediators’ analysis Immunohistochemistry
Fingerprint
Dive into the research topics where Sigal Fleisher is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Anti-Neuroinflammatory Cannabinoid Acids as a New Therapeutic Approach for Multiple Sclerosis
Sharon, N., Ventura, Y., Bernstein, N., Gorelick, J., Ben-Shabat, S. & Fleisher-Berkovich, S., 1 Apr 2026, In: Molecules. 31, 7, 1227.Research output: Contribution to journal › Article › peer-review
Open Access -
Cannabinoids, the Blood–Brain Barrier, and Neurodegeneration: Mechanisms, Dysregulation, and Therapeutic Perspectives
Ben-Shabat, S., Yarmolinsky, L., Sharon, N., Zeadnaa-Aldda, T., Dayan, S., Khalfin, B. & Fleisher-Berkovich, S., 1 Feb 2026, In: Biomolecules. 16, 2, 225.Research output: Contribution to journal › Review article › peer-review
Open Access -
Synergistic Anticancer Effects of Vitamin D and Plant-Derived Compounds: Molecular Mechanisms, Therapeutic Potential, and Nanotechnology-Enabled Delivery Approaches
Dahan, A., Ifrah, S., Yarmolinsky, L., Khalfin, B., Fleisher-Berkovich, S. & Ben-Shabat, S., 1 Mar 2026, In: International Journal of Molecular Sciences. 27, 5, 2507.Research output: Contribution to journal › Review article › peer-review
Open Access -
Etrog Citron (Citrus medica) as a Novel Source of Antiviral Agents: Overview of Its Bioactive Phytochemicals and Delivery Approaches
Dahan, A., Yarmolinsky, L., Nakonechny, F., Semenova, O., Khalfin, B., Fleisher-Berkovich, S. & Ben-Shabat, S., 1 Sep 2025, In: Pharmaceutics. 17, 9, 1173.Research output: Contribution to journal › Review article › peer-review
Open Access1 Scopus citations -
Cannabinoids’ Role in Modulating Central and Peripheral Immunity in Neurodegenerative Diseases
Sharon, N., Yarmolinsky, L., Khalfin, B., Fleisher-Berkovich, S. & Ben-Shabat, S., 1 Jun 2024, In: International Journal of Molecular Sciences. 25, 12, 6402.Research output: Contribution to journal › Review article › peer-review
Open Access6 Scopus citations -
Selected cannabis cultivars modulate glial activation: in vitro and in vivo studies
Fleisher-Berkovich, S., Sharon, N., Ventura, Y., Feinshtein, V., Gorelick, J., Bernstein, N. & Ben-Shabat, S., 1 Dec 2024, In: Journal of Cannabis Research. 6, 1, 25.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
An Emerging Strategy for Neuroinflammation Treatment: Combined Cannabidiol and Angiotensin Receptor Blockers Treatments Effectively Inhibit Glial Nitric Oxide Release
Fleisher-Berkovich, S., Battaglia, V., Baratta, F., Brusa, P., Ventura, Y., Sharon, N., Dahan, A., Collino, M. & Ben-Shabat, S., 1 Nov 2023, In: International Journal of Molecular Sciences. 24, 22, 16254.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Therapeutic Potential of Phytocannabinoid Cannabigerol for Multiple Sclerosis: Modulation of Microglial Activation In Vitro and In Vivo
Fleisher-Berkovich, S., Ventura, Y., Amoyal, M., Dahan, A., Feinshtein, V., Alfahel, L., Israelson, A., Bernstein, N., Gorelick, J. & Ben-Shabat, S., 1 Feb 2023, In: Biomolecules. 13, 2, 376.Research output: Contribution to journal › Article › peer-review
Open Access22 Scopus citations -
Candesartan ameliorates brain inflammation associated with Alzheimer's disease
Torika, N., Asraf, K., Apte, R. N. & Fleisher-Berkovich, S., 1 Mar 2018, In: CNS Neuroscience and Therapeutics. 24, 3, p. 231-242 12 p.Research output: Contribution to journal › Article › peer-review
Open Access81 Scopus citations -
Microglial activation is modulated by captopril: In vitro and in vivo studies
Asraf, K., Torika, N., Apte, R. N. & Fleisher-Berkovich, S., 1 May 2018, In: Frontiers in Cellular Neuroscience. 12, 116.Research output: Contribution to journal › Article › peer-review
Open Access49 Scopus citations
Press/Media
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Findings from Ben-Gurion University of the Negev Broadens Understanding of Nanotechnology (Synergistic Anticancer Effects of Vitamin D and Plant-Derived Compounds: Molecular Mechanisms, Therapeutic Potential, and Nanotechnology-Enabled Delivery ...)
Ben-Shabat, S., Sigal, F.-B., Dahan, A. & Khalfin, B.
19/03/26
1 item of Media coverage
Press/Media
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Findings from Ben-Gurion University of the Negev Has Provided New Information about Neurodegeneration (Cannabinoids, the Blood-Brain Barrier, and Neurodegeneration: Mechanisms, Dysregulation, and Therapeutic Perspectives)
Ben-Shabat, S., Sigal, F.-B., Sharon, N., Eldada (Zeadna), T., Dayan, S. & Khalfin, B.
10/03/26
1 item of Media coverage
Press/Media
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Ben-Gurion University of the Negev Researcher Yields New Study Findings on Neurodegenerative Diseases and Conditions (Cannabinoids' Role in Modulating Central and Peripheral Immunity in Neurodegenerative Diseases)
Sharon, N., Ben-Shabat, S., Sigal, F.-B. & Khalfin, B.
25/06/24
1 item of Media coverage
Press/Media
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Regulation of Neuroinflammation and TNF-alpha System by Cannabinoid Acids: Possible Implications for acute and chronic Multiple Sclerosis
Fleisher, S. (PI) & Ben-Shabat, S. (CoPI)
1/01/24 → 31/12/27
Project: Research
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Modulation of glial function by kinins: possible implications for brain inflammation
Fleisher, S. (PI)
1/01/11 → 31/12/14
Project: Research
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Brain inflammation : what role does bradykinin play?
Fleisher, S. (PI), Danon, A. (CoPI) & Schreiber-Avissar, S. S. (CoPI)
1/01/07 → 31/12/09
Project: Research
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Regulation of the glial inflammatory response by neuropeptides: implications for Alzheimer's disease
Fleisher, S. (PI) & Danon, A. (CoPI)
1/01/04 → 31/12/05
Project: Research