Research output per year
Research output per year
Personal profile
Research interests
- Misfolded SOD1 as a target in Amyotrophic Lateral Sclerosis (ALS) drug discovery.
- Structural basis of GPCR signal transduction.
- Protein/protein and protein/small-molecule interactions.
- Targeting protein/protein interfaces by drugs.
- Identification of biologically active compounds using in vitro selection methods.
- Computer-aided drug discovery.
Fingerprint
Dive into the research topics where Stanislav Engel is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
-
Nose-to-brain delivery of a SOD1-stabilizing small molecule ameliorates pathology in an ALS mouse model
Dhandapani, R., Bakavayev, S., Armoza, A., Bersudsky, M., Shlifer, A., Yehezkel, G., Tsitrina, A., Barak, Z., Sintov, A. C. & Engel, S., 1 Apr 2026, In: Neurotherapeutics. 23, 3, e00904.Research output: Contribution to journal › Article › peer-review
Open Access -
Reliable repurposing of the antibody interactome inside the cell
O’Shea, C. M., Shahzad, R., Aghasoleimani, K., Newman, S., Panmanee, J., Schalkwyk, L. C., Brooke, G. N., Benson, F. E., Trimmer, J. S., Bosco, D. A., Fujisawa, T., Ichijo, H., Cashman, N. R., Engel, S. & Wright, G. S. A., 1 Dec 2026, In: Nature Communications. 17, 1, 2222.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Blocking an epitope of misfolded SOD1 ameliorates disease phenotype in a model of amyotrophic lateral sclerosis
Bakavayev, S., Stavsky, A., Argueti-Ostrovsky, S., Yehezkel, G., Fridmann-Sirkis, Y., Barak, Z., Gitler, D., Israelson, A. & Engel, S., 1 Nov 2023, In: Brain. 146, 11, p. 4594-4607 14 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Functional Analysis of Spike from SARS-CoV-2 Variants Reveals the Role of Distinct Mutations in Neutralization Potential and Viral Infectivity
Kuzmina, A., Wattad, S., Engel, S., Rosenberg, E. & Taube, R., 1 Apr 2022, In: Viruses. 14, 4, 803.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
Yeast-based directed-evolution for high-throughput structural stabilization of G protein-coupled receptors (GPCRs)
Meltzer, M., Zvagelsky, T., Hadad, U., Papo, N. & Engel, S., 1 Dec 2022, In: Scientific Reports. 12, 1, 8657.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Exposure of β6/β7-Loop in Zn/Cu Superoxide Dismutase (SOD1) Is Coupled to Metal Loss and Is Transiently Reversible during Misfolding
Bakavayev, S., Argueti, S., Venkatachalam, N., Yehezkel, G., Stavsky, A., Barak, Z., Israelson, A. & Engel, S., 6 Jan 2021, In: ACS Chemical Neuroscience. 12, 1, p. 49-62 14 p.Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
SARS CoV-2 Delta variant exhibits enhanced infectivity and a minor decrease in neutralization sensitivity to convalescent or post-vaccination sera
Kuzmina, A., Wattad, S., Khalaila, Y., Ottolenghi, A., Rosental, B., Engel, S., Rosenberg, E. & Taube, R., 17 Dec 2021, In: iScience. 24, 12, 103467.Research output: Contribution to journal › Article › peer-review
Open Access25 Scopus citations -
Primate differential redoxome (PDR) – A paradigm for understanding neurodegenerative diseases
Venkatachalam, N., Bakavayev, S., Engel, D., Barak, Z. & Engel, S., 1 Sep 2020, In: Redox Biology. 36, 101683.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
An Engineered Variant of the B1 Domain of Protein G Suppresses the Aggregation and Toxicity of Intra- and Extracellular Aβ42
Banerjee, V., Oren, O., Dagan, B., Taube, R., Engel, S. & Papo, N., 20 Mar 2019, In: ACS Chemical Neuroscience. 10, 3, p. 1488-1496 9 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Cu/Zn-superoxide dismutase and wild-type like fALS SOD1 mutants produce cytotoxic quantities of H2O2 via cysteine-dependent redox short-circuit
Bakavayev, S., Chetrit, N., Zvagelsky, T., Mansour, R., Vyazmensky, M., Barak, Z., Israelson, A. & Engel, S., 1 Dec 2019, In: Scientific Reports. 9, 1, 10826.Research output: Contribution to journal › Article › peer-review
Open Access46 Scopus citations
Thesis
-
Acetohydroxy Acid Synthase: New Reaction Products and New Insights
Engel, S. (Author), Barak, Z. (Supervisor), Merchuk, J. (Supervisor) & Chipman, D. (Supervisor), 2004Student thesis: Doctoral Thesis
Press/Media
-
Data on Nanoparticles Published by Researchers at Ben-Gurion University of the Negev (Nose-to-brain delivery of a SOD1-stabilizing small molecule ameliorates pathology in an ALS mouse model)
Barak, Z., Sintov, A., Engel, S., Tsitrin, A. & Dhandapani, R. K.
23/04/26
1 item of Media coverage
Press/Media
-
Targeting Pathogenic Beta-6/Beta-7 Loop Epitope of Misfolded SOD1 to Treat Amyotrophic Lateral Sclerosis (ALS)
Engel, S. (PI)
1/01/22 → …
Project: Research
-
Misfolded Superoxide Dismutase 1 (SOD1) as target for therapeutic intervention in amyotrophic lateral sclerosis (ALS)
Engel, S. (PI)
1/01/16 → 31/12/19
Project: Research