Research output per year
Research output per year
Personal profile
Research interests
- Misfolded SOD1 as a target in Amyotrophic Lateral Sclerosis (ALS) drug discovery.
- Structural basis of GPCR signal transduction.
- Protein/protein and protein/small-molecule interactions.
- Targeting protein/protein interfaces by drugs.
- Identification of biologically active compounds using in vitro selection methods.
- Computer-aided drug discovery.
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Dive into the research topics where Stanislav Engel is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
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Blocking an epitope of misfolded SOD1 ameliorates disease phenotype in a model of amyotrophic lateral sclerosis
Bakavayev, S., Stavsky, A., Argueti-Ostrovsky, S., Yehezkel, G., Fridmann-Sirkis, Y., Barak, Z., Gitler, D., Israelson, A. & Engel, S., 1 Nov 2023, In: Brain. 146, 11, p. 4594-4607 14 p.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
Functional Analysis of Spike from SARS-CoV-2 Variants Reveals the Role of Distinct Mutations in Neutralization Potential and Viral Infectivity
Kuzmina, A., Wattad, S., Engel, S., Rosenberg, E. & Taube, R., 13 Apr 2022, In: Viruses. 14, 4, 15 p., 803.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
Yeast-based directed-evolution for high-throughput structural stabilization of G protein-coupled receptors (GPCRs)
Meltzer, M., Zvagelsky, T., Hadad, U., Papo, N. & Engel, S., 23 May 2022, In: Scientific Reports. 12, 1, 8657.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Exposure of β6/β7-Loop in Zn/Cu Superoxide Dismutase (SOD1) Is Coupled to Metal Loss and Is Transiently Reversible during Misfolding
Bakavayev, S., Argueti, S., Venkatachalam, N., Yehezkel, G., Stavsky, A., Barak, Z., Israelson, A. & Engel, S., 6 Jan 2021, In: ACS Chemical Neuroscience. 12, 1, p. 49-62 14 p.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
SARS CoV-2 Delta variant exhibits enhanced infectivity and a minor decrease in neutralization sensitivity to convalescent or post-vaccination sera
Kuzmina, A., Wattad, S., Khalaila, Y., Ottolenghi, A., Rosental, B., Engel, S., Rosenberg, E. & Taube, R., 17 Dec 2021, In: iScience. 24, 12, 103467.Research output: Contribution to journal › Article › peer-review
Open Access24 Scopus citations -
Primate differential redoxome (PDR) – A paradigm for understanding neurodegenerative diseases
Venkatachalam, N., Bakavayev, S., Engel, D., Barak, Z. & Engel, S., 1 Sep 2020, In: Redox Biology. 36, 101683.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
An Engineered Variant of the B1 Domain of Protein G Suppresses the Aggregation and Toxicity of Intra- and Extracellular Aβ42
Banerjee, V., Oren, O., Dagan, B., Taube, R., Engel, S. & Papo, N., 20 Mar 2019, In: ACS Chemical Neuroscience. 10, 3, p. 1488-1496 9 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Cu/Zn-superoxide dismutase and wild-type like fALS SOD1 mutants produce cytotoxic quantities of H2O2 via cysteine-dependent redox short-circuit
Bakavayev, S., Chetrit, N., Zvagelsky, T., Mansour, R., Vyazmensky, M., Barak, Z., Israelson, A. & Engel, S., 1 Dec 2019, In: Scientific Reports. 9, 1, 10826.Research output: Contribution to journal › Article › peer-review
Open Access44 Scopus citations -
Interactions between BIM Protein and Beta-Amyloid May Reveal a Crucial Missing Link between Alzheimer's Disease and Neuronal Cell Death
Malishev, R., Nandi, S., Śmiłowicz, D., Bakavayev, S., Engel, S., Bujanover, N., Gazit, R., Metzler-Nolte, N. & Jelinek, R., 21 Aug 2019, In: ACS Chemical Neuroscience. 10, 8, p. 3555-3564 10 p.Research output: Contribution to journal › Article › peer-review
19 Scopus citations -
A predicted unstructured C-terminal loop domain in SIRT1 is required for cathepsin B cleavage
Kumar, A., Daitsh, Y., Ben-Aderet, L., Qiq, O., Elayyan, J., Batshon, G., Reich, E., Maatuf, Y. H., Engel, S. & Dvir-Ginzberg, M., 1 Aug 2018, In: Journal of Cell Science. 131, 16, jcs.214973.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations
Thesis
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Acetohydroxy Acid Synthase: New Reaction Products and New Insights
Engel, S. (Author), Barak, Z. (Supervisor), Merchuk, J. (Supervisor) & Chipman, D. (Supervisor), 2004Student thesis: Doctoral Thesis
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Misfolded Superoxide Dismutase 1 (SOD1) as target for therapeutic intervention in amyotrophic lateral sclerosis (ALS)
Engel, S. (PI)
1/01/16 → 31/12/19
Project: Research