Personal profile

Research interests

We are developing computational and experimental tools to study the underlying mechanisms that govern the adaptive immune response in both natural infection and vaccination. Our main focus is on the role of immunological history. The nature of our work is translational, integrating the design and application of computational approaches with clinical and laboratory studies that provide data for validating and refining our computational tools.

 

Current Research Directions:

 

 

  • Host-pathogen co-evolution through the prism of adaptive immunity
  • Effects of immunological history on responses to natural infection and vaccination
  • Human Leukocyte Antigen (HLA) binding prediction and its applications in vaccine design, HLA-viral interactions, and immunodominance
  • Studying the effects of immune mediated pressure on SARS-CoV-2 viral evolution
  • Antibody dependant enhancemnet (ADE) in flaviviral infections and vaccines
 

 

 

 

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being
  • SDG 4 - Quality Education
  • SDG 15 - Life on Land
  • SDG 17 - Partnerships for the Goals

Education/Academic qualification

PhD, Computational Neuroscience, Hebrew University of Jerusalem

Award Date: 1 Oct 2008

Bachelor, Computer Science, Hebrew University of Jerusalem

Award Date: 1 Oct 1999

External positions

Affiliate Investigator, Vaccine and Infectiuos Disease Division, Fred Hutchinson Cancer Research Center

1 Jan 2015 → …

Keywords

  • QR180 Immunology
  • computational immunology
  • systems biology
  • immunoinformatics
  • Host viral co-evolution

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Collaborations and top research areas from the last five years

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  • Correlates of protection for booster doses of the SARS-CoV-2 vaccine BNT162b2

    Hertz, T., Levy, S., Ostrovsky, D., Oppenheimer, H., Zismanov, S., Kuzmina, A., Friedman, L. M., Trifkovic, S., Brice, D., Chun-Yang, L., Cohen-Lavi, L., Shemer-Avni, Y., Cohen-Lahav, M., Amichay, D., Keren-Naus, A., Voloshin, O., Weber, G., Najjar-Debbiny, R., Chazan, B. & McGargill, M. A. & 7 others, Webby, R., Chowers, M., Novack, L., Novack, V., Taube, R., Nesher, L. & Weinstein, O., 29 Jun 2023, In: Nature Communications. 14, 1, 4575.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    6 Scopus citations
  • Induction of bronchus-associated lymphoid tissue is an early life adaptation for promoting human B cell immunity

    Matsumoto, R., Gray, J., Rybkina, K., Oppenheimer, H., Levy, L., Friedman, L. M., Khamaisi, M., Meng, W., Rosenfeld, A. M., Guyer, R. S., Bradley, M. C., Chen, D., Atkinson, M. A., Brusko, T. M., Brusko, M., Connors, T. J., Luning Prak, E. T., Hershberg, U., Sims, P. A. & Hertz, T. & 1 others, Farber, D. L., 1 Aug 2023, In: Nature Immunology. 24, 8, p. 1370-1381 12 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    9 Scopus citations
  • Mapping antibody footprints using binding profiles

    Azulay, A., Cohen-Lavi, L., Friedman, L. M., McGargill, M. A. & Hertz, T., 28 Aug 2023, In: Cell Reports Methods. 3, 8, 100566.

    Research output: Contribution to journalArticlepeer-review

    Open Access
  • Obesity Is Associated with an Impaired Baseline Repertoire of Anti-Influenza Virus Antibodies

    Abd Alhadi, M., Friedman, L. M., Karlsson, E. A., Cohen-Lavi, L., Burkovitz, A., Schultz-Cherry, S., Noah, T. L., Weir, S. S., Shulman, L. M., Beck, M. A. & Hertz, T., 15 Jun 2023, In: Microbiology spectrum. 11, 3, p. e0001023 e00010-23.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    1 Scopus citations
  • Obesity is associated with impaired immune history to influenza

    Alhadi, M., Friedman, L., Karlsson, E., Cohen-Lavi, L., Burkovitz, A., Schultz-Cherry, S., Noah, T., Weir, S., Shulman, L., Beck, M. & Hertz, T., 1 May 2023, In: Journal of Immunology. 210, 1_Supplement, 1 p.

    Research output: Contribution to journalMeeting Abstractpeer-review

    Open Access
  • US National Institutes of Health Prioritization of SARS-CoV-2 Variants

    Turner, S., Alisoltani, A., Bratt, D., Cohen-Lavi, L., Dearlove, B. L., Drosten, C., Fischer, W. M., Fouchier, R. A. M., Gonzalez-Reiche, A. S., Jaroszewski, L., Khalil, Z., LeGresley, E., Johnson, M., Jones, T. C., Mühlemann, B., O'Connor, D., Sedova, M., Shukla, M., Theiler, J. & Wallace, Z. S. & 14 others, Yoon, H., Zhang, Y., van Bakel, H., Degrace, M. M., Ghedin, E., Godzik, A., Hertz, T., Korber, B., Lemieux, J., Niewiadomska, A. M., Post, D. J., Rolland, M., Scheuermann, R. & Smith, D. J., 1 May 2023, In: Emerging Infectious Diseases. 29, 5, p. E1-E9

    Research output: Contribution to journalArticlepeer-review

    Open Access
    1 Scopus citations
  • Brain-immune axis regulation is responsive to cognitive behavioral therapy and mindfulness intervention: Observations from a randomized controlled trial in patients with Crohn's disease

    Nemirovsky, A., Ilan, K., Lerner, L., Cohen-Lavi, L., Schwartz, D., Goren, G., Sergienko, R., Greenberg, D., Slonim-Nevo, V., Sarid, O., Friger, M., Regev, S., Odes, S., Hertz, T. & Monsonego, A., 1 Feb 2022, In: Brain, Behavior, and Immunity - Health. 19, 100407.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    14 Scopus citations
  • Defining the risk of SARS-CoV-2 variants on immune protection

    DeGrace, M. M., Ghedin, E., Frieman, M. B., Krammer, F., Grifoni, A., Alisoltani, A., Alter, G., Amara, R. R., Baric, R. S., Barouch, D. H., Bloom, J. D., Bloyet, L. M., Bonenfant, G., Boon, A. C. M., Boritz, E. A., Bratt, D. L., Bricker, T. L., Brown, L., Buchser, W. J. & Carreño, J. M. & 110 others, Cohen-Lavi, L., Darling, T. L., Davis-Gardner, M. E., Dearlove, B. L., Di, H., Dittmann, M., Doria-Rose, N. A., Douek, D. C., Drosten, C., Edara, V. V., Ellebedy, A., Fabrizio, T. P., Ferrari, G., Fischer, W. M., Florence, W. C., Fouchier, R. A. M., Franks, J., García-Sastre, A., Godzik, A., Gonzalez-Reiche, A. S., Gordon, A., Haagmans, B. L., Halfmann, P. J., Ho, D. D., Holbrook, M. R., Huang, Y., James, S. L., Jaroszewski, L., Jeevan, T., Johnson, R. M., Jones, T. C., Joshi, A., Kawaoka, Y., Kercher, L., Koopmans, M. P. G., Korber, B., Koren, E., Koup, R. A., LeGresley, E. B., Lemieux, J. E., Liebeskind, M. J., Liu, Z., Livingston, B., Logue, J. P., Luo, Y., McDermott, A. B., McElrath, M. J., Meliopoulos, V. A., Menachery, V. D., Montefiori, D. C., Mühlemann, B., Munster, V. J., Munt, J. E., Nair, M. S., Netzl, A., Niewiadomska, A. M., O’Dell, S., Pekosz, A., Perlman, S., Pontelli, M. C., Rockx, B., Rolland, M., Rothlauf, P. W., Sacharen, S., Scheuermann, R. H., Schmidt, S. D., Schotsaert, M., Schultz-Cherry, S., Seder, R. A., Sedova, M., Sette, A., Shabman, R. S., Shen, X., Shi, P. Y., Shukla, M., Simon, V., Stumpf, S., Sullivan, N. J., Thackray, L. B., Theiler, J., Thomas, P. G., Trifkovic, S., Türeli, S., Turner, S. A., Vakaki, M. A., van Bakel, H., VanBlargan, L. A., Vincent, L. R., Wallace, Z. S., Wang, L., Wang, M., Wang, P., Wang, W., Weaver, S. C., Webby, R. J., Weiss, C. D., Wentworth, D. E., Weston, S. M., Whelan, S. P. J., Whitener, B. M., Wilks, S. H., Xie, X., Ying, B., Yoon, H., Zhou, B., Hertz, T., Smith, D. J., Diamond, M. S., Post, D. J. & Suthar, M. S., 26 May 2022, In: Nature. 605, 7911, p. 640-652 13 p.

    Research output: Contribution to journalReview articlepeer-review

    Open Access
    96 Scopus citations
  • FLU-LISA (fluorescence-linked immunosorbent assay): high-throughput antibody profiling using antigen microarrays

    Levy, S., Abd Alhadi, M., Azulay, A., Kahana, A., Bujanover, N., Gazit, R., McGargill, M. A., Friedman, L. M. & Hertz, T., 25 Dec 2022, (Accepted/In press) In: Immunology and Cell Biology. 101, 3, p. 231-248 18 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    4 Scopus citations
  • Tcr meta-clonotypes for biomarker discovery with tcrdist3 enabled identification of public, hla-restricted clusters of sars-cov-2 tcrs

    Mayer-Blackwell, K., Schattgen, S., Cohen-Lavi, L., Crawford, J. C., Souquette, A., Gaevert, J. A., Hertz, T., Thomas, P. G., Bradley, P. G. & Fiore-Gartland, A., 30 Nov 2021, In: eLife. 10, 32 p., e68605.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    56 Scopus citations