Personal profile
Research interests
Our research is concerned with the application of nanoparticles and nucleic acids with the aim of exploring and exploiting nanoscale advantages in the world of material chemistry, to address significant chemical, biochemical, and technological problems. By approaching nanoscience from a multidisciplinary perspective, integrating biomaterials, inorganic materials, and small molecules via noncovalent and covalent interactions, we can develop new hybrid materials with emergent properties. Our main research objectives are the development of novel strategies and approaches, providing versatile tools to form composite, nano-scaled, precisely-controlled structures and ultra-sensitive DNA machineries. My mentoring and educational objectives are to establish a fascinating and attractive interdisciplinary field that can join students, postdocs, and researchers from different areas of science. I believe that the multidisciplinary emphasis of my research creates an atmosphere of varied and collaborative work that motivates students and promotes independence as they explore new and challenging areas.
Specific Research Topics
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DNA Nanotechnology: Design and applications of novel complex molecular topologies using nucleic acids and their biological consequences.
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Construction and characterization of novel RNA-based self-assemblies for biomedical applications.
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Synthesis of programmable assemblies of colloidal nanoparticles with specific and anisotropic bonding directionality.
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Synthesis, purification, and functionalization of anisotropic nanoparticles for studies relating to plasmonics and biomedical applications.
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Design and development of light-based programmable nucleic acid amplification methods for real-time bioassays using photothermal nanoparticles.
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Collaborations and top research areas from the last five years
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Photoswitchable olefins as latent metathesis monomers for controlled polymerization
Lemcoff, N., Niv, R., Iudanov, K., Gordon, G., Biswas, A., Ben-Nun, U., Shelonchik, O., Lemcoff, N. G. & Weizmann, Y., 1 Jan 2026, In: Nature Chemistry. 18, 1, p. 51-60 10 p.Research output: Contribution to journal › Article › peer-review
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Photothermal nanocomposite hydrogels enable precise nucleic acid manipulation and separation
Ben Nun, U., Yesodi, D., Lemcoff, N., Gordon, G., Katz, A., Shelonchik, O., Biswas, A. & Weizmann, Y., 1 Jan 2026, (Accepted/In press) In: Cell Biomaterials. 100406.Research output: Contribution to journal › Article › peer-review
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Advancing Topoisomerase Research Using DNA Nanotechnology
Yesodi, D., Katz, A. & Weizmann, Y., 20 Jun 2025, In: Small Methods. 9, 6, 2401113.Research output: Contribution to journal › Article › peer-review
Open Access -
Let There Be Heat: Silica-Coated Gold Nanoparticles as Photothermal Reactors for Chemical Synthesis
Biswas, A., Lemcoff, N. & Weizmann, Y., 6 May 2025, In: Accounts of Chemical Research. 58, 9, p. 1424-1434 11 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Molecular light-to-heat conversion promotes orthogonal synthesis and assembly of metal-organic frameworks
Biswas, A., Lemcoff, N., Shelonchik, O., Baranov, M., Gordon, G., Ben Nun, U. & Weizmann, Y., 1 Dec 2025, In: Nature Communications. 16, 1, 2758.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
Polymer–Carbon Black Composites for Humidity-Driven Water Uptake and Photothermally Induced Rapid Desorption
Baranov, M., Ben Nun, U., Finestone, E. Y., Zhuravel, K., Shelonchik, O., Pavan, M., Shelly, L., Ashkenasy, G., Vainer, R. & Weizmann, Y., 13 Nov 2025, In: ACS Applied Materials and Interfaces. 17, 47, p. 64438-64450 13 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Structural analysis of nanobody interactions with their prostate-specific membrane antigen binding epitopes
Alon-Zchut, G., Zalk, R., Huynh, T. T., Zalutsky, M. R., Weizmann, Y., Zarivach, R. & Papo, N., 1 Aug 2025, In: International Journal of Biological Macromolecules. 320, 145693.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Engineered exosome hybrid copper nanoscale antibiotics facilitate simultaneous self-assembly imaging and elimination of intracellular multidrug-resistant superbugs
Guo, Z., Liu, W., Liu, T., Wang, J., Jiang, H., Liu, X., Weizmann, Y. & Wang, X., 1 Jul 2024, In: Chinese Chemical Letters. 35, 7, 109060.Research output: Contribution to journal › Article › peer-review
11 Scopus citations -
In situ assembly FeS2-tetrathiomolybdate nanosheets for imaging-guided tumor vascular collapse and amplified catalytic therapy
Yin, J., Sun, W., Xiong, H., Xiao, J., Guo, Z., Liu, X., Zhang, B., Jiang, H., Weizmann, Y. & Wang, X., 1 Jun 2024, In: Nano Today. 56, 102244.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
Light-induced MOF synthesis enabling composite photothermal materials
Shelonchik, O., Lemcoff, N., Shimoni, R., Biswas, A., Yehezkel, E., Yesodi, D., Hod, I. & Weizmann, Y., 1 Dec 2024, In: Nature Communications. 15, 1, 1154.Research output: Contribution to journal › Article › peer-review
Open Access56 Scopus citations
Press/Media
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Ben-Gurion University chemists develop smart plastic-like materials that use light or gentle heat to activate
Lemcoff, G., Weizmann, Y., Shelonchik, O., Iudanov, K., Ben Nun, U. S., Gordon, G. & Lemcoff, N.
5/01/26 → 8/01/26
3 items of Media coverage
Press/Media
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New laboratory for materials science and DNA Nanotechnology research
Weizmann, Y. (PI)
1/01/20 → …
Project: Research
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New laboratory for materials science and DNA Nanotechnology research
Weizmann, Y. (PI)
1/01/20 → …
Project: Research
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Exploring plasmonic photothermal nanoparticles for ultrafast magneto-immunoPCR
Weizmann, Y. (PI)
1/01/20 → 31/12/23
Project: Research
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Programmable self-assembled RNA nanocages as an innovative intelligent delivery platform for precise cancer therapeutics
Weizmann, Y. (PI), Wang, X. X. (CoPI), Wang, M. (CoPI), Wang, Y. Y. (CoPI), Yu, F. F. (CoPI), Farouk, S. S. (CoPI), Huang, K. K. (CoPI), Cai, W. (CoPI), Ding, H. H. (CoPI), Chen, Y. Y. (CoPI), Guo, Z. Z. (CoPI), Li, C. C. (CoPI), Zeng, J. (CoPI) & Zhang, H. H. (CoPI)
1/01/20 → 31/12/22
Project: Research
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Programmable self-assembled RNA nanocages as an innovative intelligent delivery platform for precise cancer therapeutics
Weizmann, Y. (PI), Wang, X. X. (CoPI), Wang, M. (CoPI), Wang, Y. Y. (CoPI), Yu, F. F. (CoPI), Farouk, S. S. (CoPI), Huang, K. K. (CoPI), Cai, W. (CoPI), Ding, H. H. (CoPI), Chen, Y. Y. (CoPI), Guo, Z. Z. (CoPI), Li, C. C. (CoPI), Zeng, J. (CoPI) & Zhang, H. H. (CoPI)
1/01/20 → 1/01/23
Project: Research
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Exploring plasmonic photothermal nanoparticles for ultrafast magneto-immunoPCR
Weizmann, Y. (PI)
1/01/20 → 31/12/23
Project: Research
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CAREER: Programmable Artificial DNA Topology for Biological and Medical Applications
Weizmann, Y. (PI)
15/02/16 → 30/06/19
Project: Research