Activities per year
Project Details
Description
Mediterranean (MED) diet, richer in plants/seeds (and dietary polyphenols) and low in processed meat (green-MED diet) may have a pronounced beneficial effect on age-related declines that begin in middle age, reflected by changes in adiposity, cognitive function, and cardiometabolic risk. The investigators hypothesize that long-term intake of this diet will significantly potentiate the effects of a healthy lifestyle (physical activity and Mediterranean diet), constituting a powerful strategy to halt or even reverse the progression of several age-related processes related to adiposity, cardiometabolic health and cognition. The investigators further hypothesize that lifestyle intervention might modify the gut microbiota profile and that autologous fecal microbiota supplement derived from the time of maximal weight loss might halt the expected subsequent regain phase.
Short title | DIRECT-PLUS |
---|---|
Status | Finished |
Effective start/end date | 1/01/17 → 31/03/19 |
Links | https://clinicaltrials.gov/ct2/show/NCT03020186 |
Keywords
- Metabolic Syndrome
- Obesity, Abdominal
- Insulin Resistance
- Hyperinsulinism
- Glucose Metabolism Disorders
- microbiome
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Activities
- 1 Other
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conference- colors of nutrition in Israel
Shai, I. (Other), Gilron, J. (Participant), Sagi (Participant), Boussiba, S. (Participant), Fait, A. (Participant) & Hu, F. (Other)
31 Mar 2019 → 4 Apr 2019Activity: Other
Research output
- 1 Article
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The Effects of the Green-Mediterranean Diet on Cardiometabolic Health are Linked to Gut Microbiome Modifications: A Randomized Controlled Trial
Rinott, E., Meir, A. Y., Tsaban, G., Zelicha, H., Kaplan, A., Knights, D., Tuohy, K., Scholz, M. U., Koren, O., Stampfer, M. J., Wang, D. D., Shai, I. & Youngster, I., 10 Mar 2022, In: Genome Medicine. 14, 1, 29.Research output: Contribution to journal › Article › peer-review
Open Access56 Scopus citations
Press/Media
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פריצת דרך מדעית: נמצאו חיידקים במעיים הקשורים לסוכרת מסוג 2
28/08/24
1 item of Media coverage
Press/Media