Striatal population involvement in OCD symptom domains

Obsessive compulsive disorder (OCD) is associated with disturbances in different areas of flexible behaviour, including flexible actions (compulsions), threat responses (obsessions) and decision making. The striatum is a brain region that is critical for flexible behaviour, and that is also over active in OCD. The current proposal will determine how the two distinct functional neural populations in the striatum contribute to different disturbances in flexible behaviour relevant to OCD.