Project Details
Description
As more people live longer, the number of cancer cases is increasing. This is especially important as the population of people over 80 is expected to almost triple by 2050. Understanding how aging affects cancer and the activity (expression) of genes in cancer is becoming increasingly crucial. Our study is delving into how aging influences advanced and metastatic breast cancer (MBC), particularly in the most prevalent subtype of breast cancer — estrogen-receptor positive. We're exploring the patterns of gene activity related to aging in these cancer cells and evaluating the capacity of certain treatments to modulate age-related pathogenic gene expression states. Our study's main steps include: (1) Analyzing detailed clinical and molecular information from 775 MBC patients to spot unique aging-related patterns of gene expression. (2) Examining over 100k single cells from 29 MBC tumors will allow us to see these patterns With incredible detail and how different cell types (cancer, immune, strorna) play a role in age-related states. (3) Understanding how these aging- related gene activity patterns are linked to patient characteristics and certain treatments. This may illuminate how treatments can modulate harmful age-related states. (4) Conducting experiments in rats with breast cancer to see how these aging-related patterns can be influenced by genetic changes and treatments. By piecing together this puzzle, we hope to improve how advanced breast cancer is treated, considering how a patient's chronological age affects the disease and potentially how certain treatments can alter the patient's "molecular age" and improve their outcome.
Status | Finished |
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Effective start/end date | 1/09/20 → 31/08/24 |
Links | https://www.bsf.org.il/search-grant/ |
Funding
- United States-Israel Binational Science Foundation (BSF)