β-adrenergic blocking agents in the treatment of pregnancy-induced hypertension

E. Paran, G. Holzberg, M. Mazor, E. Zmora, V. Insler

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Fifty-one women with pregnancy-induced hypertension (PIH) were randomly allocated to one of three treatment groups: A: hydralazine (13); B: hydralazine and propranolol (17); and C: hydralazine and pindolol (19). All women fulfilled the pretreatment criteria and were of similar age, numbers of previous pregnancies and had systolic blood pressure (SBP) of between 140 and 160 mmHg and diastolic blood pressure (DBP) of between 95 and 110 mmHg. Hypertension was treated equally well by all three regimens (mean SBP was 133.6, 130 and 134 mmHg, respectively). Heart rate was significantly higher than baseline in group A and lower in groups B and C, as is to be expected with β-blocker treatment. Side-effects were more frequent in group A than in groups B and C, 62% of the patients on hydralazine monotherapy complained of palpitations compared to 35% on combination treatment. Fetal outcome differed in the various groups. Birth weight was significantly lower in group B, where regimen included propranolol, compared to that of group C, for whom the regimen included pindolol (3,044.7 ± 443.8 and 2,709.6 ± 485.5 gm, p < 0.05). Mean blood glucose of the newborns were similar in groups A and C (76.5 ± 16.5 and 78.6 ± 15 gm%) and significantly lower in group B (62.6 ± 14 gm%, p < 0.02). In conclusion, blood pressure was equally well treated in all three treatment groups. However, more maternal side-effects occurred in group A, the group treated with hydralazine monotherapy, while propranolol in combination with hydrazaline (group B) had some negative effects on fetal development which did not occur in pindolol/hydrazaline combination.

Original languageEnglish
Pages (from-to)119-123
Number of pages5
JournalInternational Journal of Clinical Pharmacology and Therapeutics
Volume33
Issue number2
StatePublished - 21 Feb 1995
Externally publishedYes

Keywords

  • Birth weight
  • Pregnancy-induced hypertension PIH
  • β-adrenergic blocking agents

Fingerprint

Dive into the research topics of 'β-adrenergic blocking agents in the treatment of pregnancy-induced hypertension'. Together they form a unique fingerprint.

Cite this