β-endorphin regulates interleukin 1 production and release by murine bone marrow macrophages

Ron N. Apte, Joost J. Oppenhelm, Scott K. Durum

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

The role of the nEuropeptide β-endorphin on interleukin 1 (IL-1) production by murine bone marrow-derived macrophages was assessed. β-Endorphin by itself did not induce IL-1 generation. However, over a wide range of concentrations (10-6- 10-14 M) β-endorphin potentiated lipopolysaccharide (LPS)- or silica-induced production of intracellular and extracellular IL-1. This enhancement by β-endorphin was most evident when using suboptimal doses of LPS. Naioxone, a competitive inhibttor of β-endorphin opioid receptor interactions, abrogated the enhancing effects of β-endorphin on LPS-induced IL-1 prduction. Furthermore, LPS-induced IL-1 production by macrophages (in the absence of added β-endorphin) was also partially inhibited following treatment with naioxone, suggesting that opioids derived from activated macrophages may also modulate IL-1 generation and secretion. Thus, β-endorphin-opioid receptor interactions result in enhanced production of immunomodulators such as IL-1.

Original languageEnglish
Pages (from-to)465-470
Number of pages6
JournalInternational Immunology
Volume1
Issue number5
DOIs
StatePublished - 1 Nov 1989

Keywords

  • Bone marrow macrophages
  • Interleukin 1
  • Opioid receptors
  • β-endorphin

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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