γ/δ T-cell lymphoma involving the subcutaneous tissue and associated with a hemophagocytic syndrome

I. Avinoach, S. Halevy, S. Argov, M. Sacks

Research output: Contribution to journalArticlepeer-review

79 Scopus citations

Abstract

A case of γ/δ-positive T-cell lymphoma localized primarily in the subcutaneous adipose tissue and associated with an extensive hemophagocytic syndrome and a rapid, fatal outcome is presented. Previous reports of γ/δ cutaneous and subcutaneous T-cell lymphomas are reviewed. To define the characteristics of a T-cell subset of neoplastic cells bearing the γ/δ receptor in a subcutaneous lymphoma, we undertook clinical and laboratory examinations, morphological evaluation of biopsies, electron microscopy, and extensive immunohistochemical studies. Immunohistochemical studies showed that the neoplastic cells expressed the γ/δ T-cell receptor (CD3+, CγM1+) and were CD2+, CD43+, CD45+, CD45RO+, PCNA+, but were βF1-, CD1-, CD4-, CD8-, CD15-, CD20-, CD25-, CD30-, CD45R-, CD57-, CD68- , Mac 387-, and HLA Dr-. To the best of our knowledge, this is the first report of a subcutaneous T-cell lymphoma of γ/δ type involving the subcutaneous tissue and associated with a hemophagocytic syndrome.

Original languageEnglish
Pages (from-to)426-433
Number of pages8
JournalAmerican Journal of Dermatopathology
Volume16
Issue number4
DOIs
StatePublished - 1 Jan 1994
Externally publishedYes

Keywords

  • Cutaneous T-cell lymphoma
  • Hemophagocytosis
  • T-cell lymphoma
  • T-cell receptor

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Dermatology

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