1000-Fold accelertatinon of surface biosensors using isotachophoresis

Merav Karsenty, Shimon Rubin, Tally Rosenfeld, Moran Bercovici

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

We present an experimental study of a novel method and device enabling 1000-fold acceleration of surface-based reactions. Our method leverages isotachophoresis (ITP) to deliver a highly focused sample to a pre-functionalized surface, thus enabling rapid reaction at the sensor site. Using electric current readings alone, we are able to precisely detect the location of the focused sample and deliver it with an accuracy of 50 μm to the sensor site. The presented assay is a one-step react-and-wash assay which can be performed in a simple channel and does not require flow control elements or moving parts.

Original languageEnglish
Title of host publication18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
PublisherChemical and Biological Microsystems Society
Pages1957-1959
Number of pages3
ISBN (Electronic)9780979806476
StatePublished - 1 Jan 2014
Externally publishedYes
Event18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 - San Antonio, United States
Duration: 26 Oct 201430 Oct 2014

Publication series

Name18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

Conference

Conference18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
Country/TerritoryUnited States
CitySan Antonio
Period26/10/1430/10/14

Keywords

  • Biosensors
  • Hybridization
  • Isotachophoresis
  • Microfluidics
  • Reaction kinetics

ASJC Scopus subject areas

  • Control and Systems Engineering

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