115: Placental abruption as a marker for long term cardiovascular mortality: a follow up period of more than a decade

Objective
To investigate the risk for subsequent cardiovascular events in women having placental abruption, during a follow-up period of more than 10 years.
Study Design
A population-based study comparing consecutive pregnancies of women with and without placental abruption was conducted. Deliveries occurred during the years 1988-1999 and had a follow up until the year 2010. Associations between placental abruption and maternal long-term cardiovascular hospitalizations, morbidity and mortality were investigated. Multivariable analysis was used to control for confounders.
Results
During the study period, there were 47,909 deliveries who met the inclusion criteria, of these 1.4% (n=653) occurred in patients with placental abruption. No significant differences were noted regarding subsequent long term hospitalizations due to cardiovascular causes during at least a decade of follow-up (OR= 1.2, 95% CI 0.8-1.8, P=0.314), as well as regarding invasive procedures (OR=1.5 95% CI 0.7-3.3, P=0.312; table). However, placental abruption was noted as a risk factor for long term cardiovascular mortality (OR= 6.6, 95% CI 2.3-18.4, P=0.004). The case fatality rate for placental abruption was 13.0% vs. 2.5% in the comparison group. ( P<0.001). In a multivariate logistic regression model, after controlling for confounders such as ethnicity and maternal age, placental abruption was noted as an independent risk factor for maternal long-term cardiovascular mortality (adjusted OR= 4.5; 95% CI-1.1-19.1, P = 0.041).
Subsequent cardiovascular events in women having placental abruption
Conclusion
Placental abruption is a significant risk factor for long-term cardiovascular mortality in a follow-up period of more than a decade.