Abstract
The formation of 1,3,8-trimethylallantoin from caffeine is demonstrated for the first time in vitro in rat liver slices. This compound constitutes 15% of total in vitro metabolites. With this identification, all the metabolic pathways of caffeine shown in vivo (N-demethylation, oxidation to uric acids and formation of uracil and allantoin derivatives) are demonstrated in vitro.
| Original language | English |
|---|---|
| Pages (from-to) | 407-410 |
| Number of pages | 4 |
| Journal | Research Communications in Chemical Pathology and Pharmacology |
| Volume | 52 |
| Issue number | 3 |
| State | Published - 1 Jan 1986 |
| Externally published | Yes |
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Toxicology
- Pharmacology
- General Pharmacology, Toxicology and Pharmaceutics