2-D Bi2O2Se Nanosheets for Nonenzymatic Electrochemical Detection of H2O2

Bismuth oxyselenide (Bi2O2Se) has recently emerged as a promising 2-D material for high-performance electronic and optoelectronic applications. However, its true potential is yet to be explored for chemical sensing applications. The present investigation highlights the first demonstration of a Bi2O2Se nanosheets-based sensor for nonenzymatic electrochemical detection of hydrogen peroxide (H2O2). A solution-phase method is employed to synthesize Bi2O2Se nanosheets. Cyclic voltammetry is performed to study the quantitative detection of H2O2 with a reduction potential of -0.68 V versus Ag/AgCl in nitrogen-saturated 0.1 M PBS (pH 7.4). The Bi2O2Se nanosheets-based H2O2 sensor shows efficient detection of H2O2 in the range of 50-500 μM with a sensitivity of 100 μA mA-1 cm-2, and negligible interference was observed for most of the common interferents such as NaCl, ascorbic acid, uric acid, and dopamine. Furthermore, the applicability of this electrochemical approach for practical applications is confirmed by the observation of concentration-dependent effect of H2O2 on the reduction current in artificial sweat, making Bi2O2Se nanosheets a compelling electrocatalyst candidate for the development of new wearable glucose sensors.