3-D docking of protein molecules

Daniel Fischer, Raquel Norel, Ruth Nussinov, Haim J. Wolfson

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

11 Scopus citations

Abstract

We present geometric algorithms which tackle the docking problem in Molecular Biology. This problem is a central research topic both for synthetic drug design and for biomolecular recognition and interaction of proteins in general. Our algorithms have been implemented and experimented on several ‘real world’ biological examples. The preliminary experimental results show an order of magnitude improvement in the actual run-time of the algorithms in comparison to previously published techniques. The matching part of our algorithm is based on the Geometric Hashing technique, originally developed for Computer Vision applications. The algorithmic similarity between the problems emphasizes the importance of interdisciplinary research in Computational Molecular Biology. Future research directions are outlined as well.

Original languageEnglish
Title of host publicationCombinatorial Pattern Matching - 4th Annual Symposium, CPM 1993, Proceedings
EditorsAlberto Apostolico, Alberto Apostolico, Maxime Crochemore , Zvi Galil, Zvi Galil, Udi Manber
PublisherSpringer Verlag
Pages20-34
Number of pages15
ISBN (Print)9783540567646
DOIs
StatePublished - 1 Jan 1993
Externally publishedYes
EventConference of the European Society for Fuzzy Logic and Technology, EUSFLAT 2017 and 16th International Workshop on Intuitionistic Fuzzy Sets and Generalized Nets, IWIFSGN 2017 - Warsaw, Poland
Duration: 11 Sep 201715 Sep 2017

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume684 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

ConferenceConference of the European Society for Fuzzy Logic and Technology, EUSFLAT 2017 and 16th International Workshop on Intuitionistic Fuzzy Sets and Generalized Nets, IWIFSGN 2017
Country/TerritoryPoland
CityWarsaw
Period11/09/1715/09/17

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science (all)

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