3,5,4'-trihydroxy-6,7,3'-trimethoxyflavone protects against beta amyloid-induced neurotoxicity through antioxidative activity and interference with cell signaling

Keyphrases

• Alzheimer's Disease 100%
• Amyloid beta 100%
• Cell Signaling 100%
• Antioxidant System 100%
• Neurotoxicity 100%
• Protein Kinase 66%
• Neuronal Cells 66%
• Oxidative Stress 66%
• C-Jun N-terminal Kinase 66%
• Achillea Fragrantissima 66%
• Protein Stress 66%
• Stress-activated Protein Kinase 66%
• Cognitive Function 33%
• Cell Viability 33%
• Flavonoids 33%
• Enzyme-linked Immunosorbent Assay (ELISA) 33%
• Phosphorylation 33%
• Neurodegenerative Diseases 33%
• Signaling Molecules 33%
• Cytotoxicity 33%
• Potential Therapeutics 33%
• Reactive Oxygen Species 33%
• Effective Approach 33%
• Mitogen-activated Protein Kinase 33%
• Reactive Oxygen Species Level 33%
• Cellular Level 33%
• Major Contributor 33%
• Intracellular Reactive Oxygen Species 33%
• Induced Toxicity 33%
• Chromatographic Methods 33%
• Memory Function 33%
• ERK2 33%
• N2a Neuroblastoma Cells 33%
• Phosphorylated Extracellular Signal-regulated Kinase 33%
• Cell-conditioned Medium 33%
• Intracellular Accumulation 33%
• Kinase Family 33%
• 2′,7′-Dichlorofluorescein 33%
• Diacetate 33%
• Cell Staining 33%
• ERK1 33%
• Lactate Dehydrogenase Activity 33%
• Crystal Violet 33%
• Toxicity Stress 33%

Neuroscience

• Alzheimer's Disease 100%
• Oxidative Stress 100%
• Beta Amyloid 100%
• Cell Signaling 100%
• Amino Terminal Sequence 100%
• Kinase 100%
• C-Jun N-Terminal Kinases 100%
• Protein Kinase C 100%
• Neurotoxicity 100%
• Reactive Oxygen Species 100%
• Mitogen Activated Protein Kinase 3 100%
• Cognitive Function 50%
• Cell Line 50%
• Neurodegenerative Disorder 50%
• Treatment of Alzheimer's Disease 50%
• Mitogen-Activated Protein Kinase 50%
• Staining Technique 50%
• Cytotoxicity 50%
• Extracellular Signal-Regulated Kinases 50%
• Lactate Dehydrogenase 50%
• Cell Viability 50%
• Neuroblastoma 50%
• Flavonoid 50%
• Crystal Violet 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Alzheimer's Disease 100%
• Amyloid 100%
• Antioxidant 100%
• Neurotoxicity 100%
• Phosphotransferase 66%
• Stress Activated Protein Kinase 66%
• Mitogen Activated Protein Kinase 66%
• Reactive Oxygen Metabolite 66%
• Protein Kinase C 66%
• Mitogen Activated Protein Kinase 3 66%
• Achillea 66%
• Disease 33%
• Enzyme-Linked Immunosorbent Assay 33%
• Degenerative Disease 33%
• Lactate Dehydrogenase 33%
• Cytotoxicity 33%
• Cell Viability 33%
• Dichlorofluorescein 33%
• Crystal Violet 33%
• Flavonoid 33%
• Neuroblastoma 33%
• Acetoacetic Acid 33%