4-aminosalicylic acid adducts

Suryanarayan Cherukuvada; Geetha Bolla; Kanishka Sikligar; Ashwini Nangia

doi:10.1021/cg301798s

4-aminosalicylic acid adducts

Suryanarayan Cherukuvada, Geetha Bolla, Kanishka Sikligar, Ashwini Nangia

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

4-Aminosalicylic acid (p-aminosalicylic acid, PAS), an antituberculosis drug, is a model active pharmaceutical ingredient to study salt and cocrystal formation in a multiple hydrogen-bonding functionality molecule with carboxylic acid, amine, and phenol groups. A cytosine salt CYT⁺-PAS^-, salt cocrystal hydrate CYT⁺-PAS^--CYT-H₂O, and nicotinamide cocrystal hydrate PAS-NAM-H₂O, are described in this article. Furthermore, X-ray crystal structures of PAS sodium dihydrate, sulfate, and mesylate salts and dehydration/rehydration behavior of the sodium salt by powder X-ray diffraction are discussed.

Original language	English
Pages (from-to)	1551-1557
Number of pages	7
Journal	Crystal Growth and Design
Volume	13
Issue number	4
DOIs	https://doi.org/10.1021/cg301798s
State	Published - 3 Apr 2013
Externally published	Yes

ASJC Scopus subject areas

General Chemistry
General Materials Science
Condensed Matter Physics

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10.1021/cg301798s

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title = "4-aminosalicylic acid adducts",

abstract = "4-Aminosalicylic acid (p-aminosalicylic acid, PAS), an antituberculosis drug, is a model active pharmaceutical ingredient to study salt and cocrystal formation in a multiple hydrogen-bonding functionality molecule with carboxylic acid, amine, and phenol groups. A cytosine salt CYT+-PAS-, salt cocrystal hydrate CYT+-PAS--CYT-H2O, and nicotinamide cocrystal hydrate PAS-NAM-H2O, are described in this article. Furthermore, X-ray crystal structures of PAS sodium dihydrate, sulfate, and mesylate salts and dehydration/rehydration behavior of the sodium salt by powder X-ray diffraction are discussed.",

author = "Suryanarayan Cherukuvada and Geetha Bolla and Kanishka Sikligar and Ashwini Nangia",

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T1 - 4-aminosalicylic acid adducts

AU - Cherukuvada, Suryanarayan

AU - Bolla, Geetha

AU - Sikligar, Kanishka

AU - Nangia, Ashwini

PY - 2013/4/3

Y1 - 2013/4/3

N2 - 4-Aminosalicylic acid (p-aminosalicylic acid, PAS), an antituberculosis drug, is a model active pharmaceutical ingredient to study salt and cocrystal formation in a multiple hydrogen-bonding functionality molecule with carboxylic acid, amine, and phenol groups. A cytosine salt CYT+-PAS-, salt cocrystal hydrate CYT+-PAS--CYT-H2O, and nicotinamide cocrystal hydrate PAS-NAM-H2O, are described in this article. Furthermore, X-ray crystal structures of PAS sodium dihydrate, sulfate, and mesylate salts and dehydration/rehydration behavior of the sodium salt by powder X-ray diffraction are discussed.

AB - 4-Aminosalicylic acid (p-aminosalicylic acid, PAS), an antituberculosis drug, is a model active pharmaceutical ingredient to study salt and cocrystal formation in a multiple hydrogen-bonding functionality molecule with carboxylic acid, amine, and phenol groups. A cytosine salt CYT+-PAS-, salt cocrystal hydrate CYT+-PAS--CYT-H2O, and nicotinamide cocrystal hydrate PAS-NAM-H2O, are described in this article. Furthermore, X-ray crystal structures of PAS sodium dihydrate, sulfate, and mesylate salts and dehydration/rehydration behavior of the sodium salt by powder X-ray diffraction are discussed.

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U2 - 10.1021/cg301798s

DO - 10.1021/cg301798s

M3 - Article

AN - SCOPUS:84875802425

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VL - 13

SP - 1551

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JO - Crystal Growth and Design

JF - Crystal Growth and Design

IS - 4

ER -

4-aminosalicylic acid adducts

Abstract

ASJC Scopus subject areas

UN SDGs

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