452: Recurrence of preterm delivery in women with a family history of preterm delivery

Yehonatan Sherf, Eyal Sheiner, Ilana Shoham-Vardi, Ruslan Sergienko, Jamie Klein, Natalya Bilenko

Research output: Contribution to journalMeeting Abstractpeer-review


To evaluate the role of familial history of preterm delivery on the risk of preterm delivery in the next generation.
Study Design
A retrospective population-based study was conducted. Perinatal information was gathered from 2311 familial triads, comprised of mothers (F0), daughters (F1) and children (F2). All births occurred in the same regional medical center between the years 1991-2013. If a mother in the F0 generation gave birth preterm, at any stage during her reproductive history, it was documented as family history of preterm delivery. Logistic regression was performed to assess the risk for F1 delivering preterm if (a) she was born preterm herself or (b) she born at term but her mother gave birth preterm to any of her siblings.

The risk for preterm delivery of the F1 parturient was 34% greater if their mother (F0) at any of her births had delivered preterm, controlling for F1 parity, maternal age at delivery and preeclampsia (adjusted OR=1.34, CI 95% - 1.01-1.77; P=0.042; Table). A non-significant increase in the risk for F1 giving birth preterm if she herself was born preterm was demonstrated (adjusted OR=1.29, CI 95% - 0.72-2.3; P=0.388).
Maternal history of preterm delivery is associated with increased risk of preterm delivery of all her daughters, even those who had not themselves been born preterm. Although future studies are needed, it appears that a parturient with a family history of preterm delivery may benefit from careful surveillance.
Original languageEnglish
Pages (from-to)S249
JournalAmerican Journal of Obstetrics and Gynecology
Issue number1
StatePublished - 31 Jan 2016


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