5‐hydroxytryptamine in platelets of torsion dystonia patients

Amos D. Korczyn, Jeanette Lazarovits, Alexander Dvilanski, Yechiel Eshel, Ilana Nathan

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

ABSTRACT – In an effort to explore possible changes in 5‐hydroxytryptamine (5‐HT) metabolism in idiopathic torsion dystonia (ITD), platelets from patients were studied. Platelet 5‐HT concentrations did not differ from those in matched controls. 5‐HT uptake by the platelets was also studied, and the results demonstrated significantly higher Km values, but Vmax values were normal among patients. Inhibition by imipramine of 5‐HT uptake by platelets taken from ITD patients was also normal. The therapeutic implications of the low affinity of 5‐HT to its platelet receptors are discussed.

Original languageEnglish
Pages (from-to)171-173
Number of pages3
JournalActa Neurologica Scandinavica
Volume71
Issue number2
DOIs
StatePublished - 1 Jan 1985

Keywords

  • 5‐HT
  • platelets
  • torsion dystonia

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