TY - JOUR
T1 - 5‐hydroxytryptamine in platelets of torsion dystonia patients
AU - Korczyn, Amos D.
AU - Lazarovits, Jeanette
AU - Dvilanski, Alexander
AU - Eshel, Yechiel
AU - Nathan, Ilana
PY - 1985/1/1
Y1 - 1985/1/1
N2 - ABSTRACT – In an effort to explore possible changes in 5‐hydroxytryptamine (5‐HT) metabolism in idiopathic torsion dystonia (ITD), platelets from patients were studied. Platelet 5‐HT concentrations did not differ from those in matched controls. 5‐HT uptake by the platelets was also studied, and the results demonstrated significantly higher Km values, but Vmax values were normal among patients. Inhibition by imipramine of 5‐HT uptake by platelets taken from ITD patients was also normal. The therapeutic implications of the low affinity of 5‐HT to its platelet receptors are discussed.
AB - ABSTRACT – In an effort to explore possible changes in 5‐hydroxytryptamine (5‐HT) metabolism in idiopathic torsion dystonia (ITD), platelets from patients were studied. Platelet 5‐HT concentrations did not differ from those in matched controls. 5‐HT uptake by the platelets was also studied, and the results demonstrated significantly higher Km values, but Vmax values were normal among patients. Inhibition by imipramine of 5‐HT uptake by platelets taken from ITD patients was also normal. The therapeutic implications of the low affinity of 5‐HT to its platelet receptors are discussed.
KW - 5‐HT
KW - platelets
KW - torsion dystonia
UR - http://www.scopus.com/inward/record.url?scp=0021932645&partnerID=8YFLogxK
U2 - 10.1111/j.1600-0404.1985.tb03184.x
DO - 10.1111/j.1600-0404.1985.tb03184.x
M3 - Article
C2 - 3984684
AN - SCOPUS:0021932645
SN - 0001-6314
VL - 71
SP - 171
EP - 173
JO - Acta Neurologica Scandinavica
JF - Acta Neurologica Scandinavica
IS - 2
ER -