ABSTRACT – In an effort to explore possible changes in 5‐hydroxytryptamine (5‐HT) metabolism in idiopathic torsion dystonia (ITD), platelets from patients were studied. Platelet 5‐HT concentrations did not differ from those in matched controls. 5‐HT uptake by the platelets was also studied, and the results demonstrated significantly higher Km values, but Vmax values were normal among patients. Inhibition by imipramine of 5‐HT uptake by platelets taken from ITD patients was also normal. The therapeutic implications of the low affinity of 5‐HT to its platelet receptors are discussed.
|Number of pages||3|
|Journal||Acta Neurologica Scandinavica|
|State||Published - 1 Jan 1985|
- torsion dystonia