6-Gingerol-derived semisynthetic analogs mitigate oxidative stress, and reverse acrylamide induced neurotoxicity in zebrafish

Tamilvelan Manjunathan; Ajay Guru; B. Haridevamuthu; Rambabu Dandela; Jesu Arokiaraj; Pushparathinam Gopinath

doi:10.1039/d3nj01004j

6-Gingerol-derived semisynthetic analogs mitigate oxidative stress, and reverse acrylamide induced neurotoxicity in zebrafish

Tamilvelan Manjunathan, Ajay Guru, B. Haridevamuthu, Rambabu Dandela, Jesu Arokiaraj, Pushparathinam Gopinath

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

A semisynthetic strategy has been developed for the synthesis of novel 6-gingerol based analogs using simple and robust chemistries. These newer analogs were able to quench ROS and RNS in vitro, and retrieve the oxidative stress induced by acrylamide in zebrafish larvae. They are also capable of restoring the locomotion behavior in zebrafish.

Original language	English
Pages (from-to)	10488-10492
Number of pages	5
Journal	New Journal of Chemistry
Volume	47
Issue number	22
DOIs	https://doi.org/10.1039/d3nj01004j
State	Published - 17 May 2023
Externally published	Yes

ASJC Scopus subject areas

Catalysis
General Chemistry
Materials Chemistry

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10.1039/d3nj01004j

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abstract = "A semisynthetic strategy has been developed for the synthesis of novel 6-gingerol based analogs using simple and robust chemistries. These newer analogs were able to quench ROS and RNS in vitro, and retrieve the oxidative stress induced by acrylamide in zebrafish larvae. They are also capable of restoring the locomotion behavior in zebrafish.",

author = "Tamilvelan Manjunathan and Ajay Guru and B. Haridevamuthu and Rambabu Dandela and Jesu Arokiaraj and Pushparathinam Gopinath",

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AU - Manjunathan, Tamilvelan

AU - Guru, Ajay

AU - Haridevamuthu, B.

AU - Dandela, Rambabu

AU - Arokiaraj, Jesu

AU - Gopinath, Pushparathinam

PY - 2023/5/17

Y1 - 2023/5/17

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AB - A semisynthetic strategy has been developed for the synthesis of novel 6-gingerol based analogs using simple and robust chemistries. These newer analogs were able to quench ROS and RNS in vitro, and retrieve the oxidative stress induced by acrylamide in zebrafish larvae. They are also capable of restoring the locomotion behavior in zebrafish.

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JO - New Journal of Chemistry

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6-Gingerol-derived semisynthetic analogs mitigate oxidative stress, and reverse acrylamide induced neurotoxicity in zebrafish

Abstract

ASJC Scopus subject areas

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