Abstract
Objective
To investigate whether a diagnosis of anemia during pregnancy is a risk factor for subsequent long-term cardiovascular morbidity, in a follow-up period of more than a decade.
Study Design
A population-based study comparing long-term cardiovascular complications of consecutive pregnancies of women with and without a diagnosis of anemia during pregnancy (defined as hemoglobin level< 10 gr/dL) was conducted. Deliveries occurred during the years 1988-1999 and had a follow up period (for cardiovascular morbidity) until 2010. Incidence of long-term cardiovascular hospitalizations and morbidity was compared between women with anemia and women who gave birth at the same period with no anemia. Multiple logistic regression models were constructed to control for confounders.
Results
During the study period there were 47909 deliveries who met the inclusion criteria, 12,362 (25.8%) occurred in patients who were diagnosed with anemia during pregnancy. No significant differences were noted regarding subsequent long term non-invasive and invasive cardiovascular procedures. Nevertheless, patients with anemia had significantly higher rates of complex cardiovascular events, such as congestive heart failure, cardiac arrest etc. (OR=1.7, 95% CI 1-2.8, P=0.042; table). In a multivariate logistic regression model, controlling for confounders such as maternal age and ethnicity, anemia during pregnancy was noted as an independent risk factor for long-term cardiovascular hospitalizations (adjusted OR= 1.3; 95% CI-1.1-1.4, P = 0.001).
Conclusion
Anemia during pregnancy is associated with an increased risk for long-term cardiovascular morbidity in a follow-up period of more than a decade.
To investigate whether a diagnosis of anemia during pregnancy is a risk factor for subsequent long-term cardiovascular morbidity, in a follow-up period of more than a decade.
Study Design
A population-based study comparing long-term cardiovascular complications of consecutive pregnancies of women with and without a diagnosis of anemia during pregnancy (defined as hemoglobin level< 10 gr/dL) was conducted. Deliveries occurred during the years 1988-1999 and had a follow up period (for cardiovascular morbidity) until 2010. Incidence of long-term cardiovascular hospitalizations and morbidity was compared between women with anemia and women who gave birth at the same period with no anemia. Multiple logistic regression models were constructed to control for confounders.
Results
During the study period there were 47909 deliveries who met the inclusion criteria, 12,362 (25.8%) occurred in patients who were diagnosed with anemia during pregnancy. No significant differences were noted regarding subsequent long term non-invasive and invasive cardiovascular procedures. Nevertheless, patients with anemia had significantly higher rates of complex cardiovascular events, such as congestive heart failure, cardiac arrest etc. (OR=1.7, 95% CI 1-2.8, P=0.042; table). In a multivariate logistic regression model, controlling for confounders such as maternal age and ethnicity, anemia during pregnancy was noted as an independent risk factor for long-term cardiovascular hospitalizations (adjusted OR= 1.3; 95% CI-1.1-1.4, P = 0.001).
Conclusion
Anemia during pregnancy is associated with an increased risk for long-term cardiovascular morbidity in a follow-up period of more than a decade.
| Original language | English |
|---|---|
| Pages (from-to) | S285 |
| Journal | American Journal of Obstetrics and Gynecology |
| Volume | 208 |
| Issue number | 1 |
| DOIs | |
| State | Published - 31 Jan 2013 |