A careful analysis of the incubation products of Δ9 tetrahydrocannabinol (THC) with rat liver microsomes revealed the presence of a hitherto unidentified metabolite. Mass spectral data suggested the 7 oxo derivative; LiAlH4 reduction of this product gave 7 hydroxy Δ9 tetrahydrocannabinol substantiating this assignment. Such an aldehyde is a likely intermediate in the detoxication of Δ9 THC which leads to acidic products.
|Number of pages||7|
|Journal||Research Communications in Chemical Pathology and Pharmacology|
|State||Published - 1 Jan 1974|
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Pharmacology, Toxicology and Pharmaceutics (all)