7 Oxo Δ1 tetrahydrocannabinol: a novel metabolite of Δ1 tetrahydrocannabinol

Z. Ben Zvi; S. Burstein

7 Oxo Δ¹ tetrahydrocannabinol: a novel metabolite of Δ¹ tetrahydrocannabinol

Z. Ben Zvi, S. Burstein

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

A careful analysis of the incubation products of Δ⁹ tetrahydrocannabinol (THC) with rat liver microsomes revealed the presence of a hitherto unidentified metabolite. Mass spectral data suggested the 7 oxo derivative; LiAlH₄ reduction of this product gave 7 hydroxy Δ⁹ tetrahydrocannabinol substantiating this assignment. Such an aldehyde is a likely intermediate in the detoxication of Δ⁹ THC which leads to acidic products.

Original language	English
Pages (from-to)	223-229
Number of pages	7
Journal	Research Communications in Chemical Pathology and Pharmacology
Volume	8
Issue number	2
State	Published - 1 Jan 1974
Externally published	Yes

ASJC Scopus subject areas

Pathology and Forensic Medicine
Toxicology
Pharmacology
General Pharmacology, Toxicology and Pharmaceutics

Cite this

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title = "7 Oxo Δ1 tetrahydrocannabinol: a novel metabolite of Δ1 tetrahydrocannabinol",

abstract = "A careful analysis of the incubation products of Δ9 tetrahydrocannabinol (THC) with rat liver microsomes revealed the presence of a hitherto unidentified metabolite. Mass spectral data suggested the 7 oxo derivative; LiAlH4 reduction of this product gave 7 hydroxy Δ9 tetrahydrocannabinol substantiating this assignment. Such an aldehyde is a likely intermediate in the detoxication of Δ9 THC which leads to acidic products.",

author = "{Ben Zvi}, Z. and S. Burstein",

year = "1974",

month = jan,

day = "1",

language = "English",

volume = "8",

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TY - JOUR

T1 - 7 Oxo Δ1 tetrahydrocannabinol

T2 - a novel metabolite of Δ1 tetrahydrocannabinol

AU - Ben Zvi, Z.

AU - Burstein, S.

PY - 1974/1/1

Y1 - 1974/1/1

N2 - A careful analysis of the incubation products of Δ9 tetrahydrocannabinol (THC) with rat liver microsomes revealed the presence of a hitherto unidentified metabolite. Mass spectral data suggested the 7 oxo derivative; LiAlH4 reduction of this product gave 7 hydroxy Δ9 tetrahydrocannabinol substantiating this assignment. Such an aldehyde is a likely intermediate in the detoxication of Δ9 THC which leads to acidic products.

AB - A careful analysis of the incubation products of Δ9 tetrahydrocannabinol (THC) with rat liver microsomes revealed the presence of a hitherto unidentified metabolite. Mass spectral data suggested the 7 oxo derivative; LiAlH4 reduction of this product gave 7 hydroxy Δ9 tetrahydrocannabinol substantiating this assignment. Such an aldehyde is a likely intermediate in the detoxication of Δ9 THC which leads to acidic products.

UR - http://www.scopus.com/inward/record.url?scp=0016077374&partnerID=8YFLogxK

M3 - Article

C2 - 4855455

AN - SCOPUS:0016077374

SN - 0034-5164

VL - 8

SP - 223

EP - 229

JO - Research Communications in Chemical Pathology and Pharmacology

JF - Research Communications in Chemical Pathology and Pharmacology

IS - 2

ER -

7 Oxo Δ¹ tetrahydrocannabinol: a novel metabolite of Δ¹ tetrahydrocannabinol

Abstract

ASJC Scopus subject areas

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