7 to 10 years' follow-up of 573 patients with elevated prostate-specific antigen (>4 ng/ml) or/and suspected rectal examination: Biopsies protocol and follow-up guides

Sergey Kravchick, Shmuel Cytron, Eugeny Stepnov, David Ben-Dor, Kravchenko Yakov, Ronit Peled

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1 Scopus citations

Abstract

Purpose: In this study, we tried to design a scheme for performing transrectal ultrasonographic (TRUS)-biopsies that would be accurate and include the optimal number of cores. Patients and Methods: We included in this study 600 consecutive patients with suspicious findings on a per-rectum examination and/or an elevated prostate-specific antigen (PSA) (>4 ng/mL) level. Patients were followed for 7 to 10 years. In all patients, we took from 8 to 16 biopsy samples, according to the prostate volume, from the lateral aspects. In the second session, the biopsy samples were taken medially; in the third session, we included the transitional zone, while in consecutive sessions, we increased the number of cores from all areas. Results: Only 573 of the patients remained in follow-up. TRUS-biopsy detected prostate cancer (PCa) in 257 patients (44.85% overall detection rate). The detection rate in the first and second sessions was 32.98% and 14.94%, respectively, reaching 13.2% and 2.17%, in the third and fourth sessions, respectively. Prostate volumes were significantly smaller (52.9 ± 22.4 cc vs 58.9 ± 23.8 cc, P < 0.002) and the PSA/adenoma/prostate volumes ratio (ad-pro) ratio was higher (18.3 ±9 vs 13.96, P<0/001) in the patients with PCa. Patients with PCa underwent fewer biopsy procedures and biopsy sessions than patients without a diagnosis of PCa (14.9 ±8.9 vs 20.4 ± 12, P < 0.001;1.3 ± 0.6 vs 1.7 ± 0.9, P < 0.001). Biopsy samples obtained from the base were positive for cancer only in larger prostates with a mean volume of 54.3 ± 15.3 cc. Numbers of biopsy procedures and PSA/ad-pro ratio were the strongest predictive factors for PCa detection (P< 0.001). Conclusions: In patients with a prostate volume ≥53 cc and PSA/ad-pro ratio ≥18, the optimal biopsy cores should be ≥15. Using this scheme, the discontinuation of biopsy procedures might be considered after three consecutive sessions.

Original languageEnglish
Pages (from-to)1007-1013
Number of pages7
JournalJournal of Endourology
Volume23
Issue number6
DOIs
StatePublished - 1 Jun 2009
Externally publishedYes

ASJC Scopus subject areas

  • Urology

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