Isolated Obesity in Pregnancy is Associated with Low Levels and Activity of α1-Antitrypsin

Shimrit Yaniv Salem, Galit Shahaf, Eli Lewis, Joel Baron, Tamar Madar, Guy Twina, Eyal Sheiner

Research output: Contribution to journalMeeting Abstractpeer-review


To examine possible correlation between α1-antitrypsin (AAT) levels and activity in parturients with and without isolated obesity (after excluding complications such as diabetes mellitus) during pregnancy.
Study Design
A prospective case-control study was conducted. AAT levels were determined by standard human AAT ELISA according to the manufacturer’s instructions (Immunology Consultants Laboratories, OR, USA). Elastase inhibition was determined by kinetic assay according to manufacturer recommendations (Sigma-Aldrich, Rehovot, Israel). Assays were performed in duplicates and repeated twice for each sample in separate sessions. Patients with diabetes mellitus were excluded from the study. The Mann-Whitney U-test was used to evaluate the statistical differences between groups in AAT concentration and activity.
During the study period 43 parturients were recruited: 21 had isolated obesity and the control group consisted of 22 non-obese parturients. AAT concentration was lower in obese as compared with non-obese parturients (8.31 ± 0.28 mg/ml vs. 9.5 ± 0.37 mg/ml, p=0.0155; figure 1A). Likewise, the elastase inhibitory capacity was lower in the obese vs. the non-obese parturients (mean 27.33 ± 2.08 % vs. 43.73 ± 3.1%, p<0.001; figure 1B).
Isolated obesity in pregnancy is associated with lower levels and activity of AAT. These findings correlate with the reduced concentration and activity of AAT found in patients with gestational diabetes mellitus. Accordingly, it might suggest an inflammatory cascade associating between obesity and the development of insulin resistance.
Original languageEnglish GB
Pages (from-to)S358
JournalAmerican Journal of Obstetrics Gynecology
Issue number1
StatePublished - 2014


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