Abstract
Objective
The present study was aimed to evaluate long term morbidity of patients with preeclampsia.
Study Design
A retrospective cohort study was conducted, including women who gave birth between the years of 1988 to 1998, and had a follow-up until 2009. Data were extracted by linking a computerized database of hospitalizations with computerized database containing maternal records from the district hospital during the study period. The exposed group consisted of 2072 patients with preeclampsia (either mild or severe) in one or more of their pregnancies that were compared to 20742 patients without preeclampsia (non exposed group). Excluded from the study were patients with chronic hypertension and pre-gestational diabetes before the index pregnancy (in 1988 to 1998). Data were collected regarding subsequent hospitalizations in internal medicine, oncology, nephrology, neurology, cardiac intensive care unit, and hematology as well as regarding chronic hypertension during the follow up period until December 2009.
Results
Patients with preeclampsia had significantly higher rates of chronic hypertension diagnosed after the index pregnancy as compared with patients without preeclampsia (12.5% vs. 0.9%; OR=15.8, 95% CI 12.9-19.3; P<0.001). Likewise, during at least 10 years of follow-up, patients with preeclampsia were more likely to be hospitalized at least once in internal medicine, oncology, nephrology, neurology, cardiac intensive care unit, and hematology (13.7% vs. 11.4%; OR=1.2, 95% CI 1.1-1.4; P=0.002) as compared with patients without preeclampsia. In particular, exposed women had 582 hospitalizations (0.28 hospitalization/patient), while the non-exposed patients had a total of 4687 hospitalizations (0.23 hospitalization/patient).
Conclusion
Preeclampsia is a significant risk factor for long-term morbidity such as chronic hypertension and hospitalizations in internal medicine, oncology, nephrology, neurology, cardiac intensive care unit, and hematology.
The present study was aimed to evaluate long term morbidity of patients with preeclampsia.
Study Design
A retrospective cohort study was conducted, including women who gave birth between the years of 1988 to 1998, and had a follow-up until 2009. Data were extracted by linking a computerized database of hospitalizations with computerized database containing maternal records from the district hospital during the study period. The exposed group consisted of 2072 patients with preeclampsia (either mild or severe) in one or more of their pregnancies that were compared to 20742 patients without preeclampsia (non exposed group). Excluded from the study were patients with chronic hypertension and pre-gestational diabetes before the index pregnancy (in 1988 to 1998). Data were collected regarding subsequent hospitalizations in internal medicine, oncology, nephrology, neurology, cardiac intensive care unit, and hematology as well as regarding chronic hypertension during the follow up period until December 2009.
Results
Patients with preeclampsia had significantly higher rates of chronic hypertension diagnosed after the index pregnancy as compared with patients without preeclampsia (12.5% vs. 0.9%; OR=15.8, 95% CI 12.9-19.3; P<0.001). Likewise, during at least 10 years of follow-up, patients with preeclampsia were more likely to be hospitalized at least once in internal medicine, oncology, nephrology, neurology, cardiac intensive care unit, and hematology (13.7% vs. 11.4%; OR=1.2, 95% CI 1.1-1.4; P=0.002) as compared with patients without preeclampsia. In particular, exposed women had 582 hospitalizations (0.28 hospitalization/patient), while the non-exposed patients had a total of 4687 hospitalizations (0.23 hospitalization/patient).
Conclusion
Preeclampsia is a significant risk factor for long-term morbidity such as chronic hypertension and hospitalizations in internal medicine, oncology, nephrology, neurology, cardiac intensive care unit, and hematology.
| Original language | English |
|---|---|
| Pages (from-to) | S332-S333 |
| Journal | American Journal of Obstetrics and Gynecology |
| Volume | 206 |
| Issue number | 1 |
| DOIs | |
| State | Published - 31 Jan 2012 |