Low Levels and Activity of Circulating Alpha-1 Antitrypsin are a Possible Cause for Severe Preeclampsia

Guy Twina; Eli C Lewis; Galit Shahaf; Shimrit Yaniv Salem; Tamar Madar; Joel Baron; Arnon Wiznitzer; Moshe Mazor; Gershon Holcberg; Eyal Sheiner

doi:10.1016/j.ajog.2011.10.775

Low Levels and Activity of Circulating Alpha-1 Antitrypsin are a Possible Cause for Severe Preeclampsia

Guy Twina, Eli C Lewis, Galit Shahaf, Shimrit Yaniv Salem, Tamar Madar, Joel Baron, Arnon Wiznitzer, Moshe Mazor, Gershon Holcberg, Eyal Sheiner

Research output: Contribution to journal › Meeting Abstract

Abstract

Alpha-1 antitrypsin (AAT) inhibits a wide variety of proteases and possesses anti-inflammatory and tissue-protective properties. During normal pregnancy, circulating AAT rises towards the third trimester. AAT was previously linked to placental and pregnancy complications. Preeclampsia is a multisystem pregnancy disorder of unknown cause. An immunological insight into the origin of preeclampsia was previously suggested. The purpose of the present prospective study was to examine whether low plasma concentration and activity of AAT might correlate with severe preeclampsia.

Original language	English
Article number	abstract 757
Pages (from-to)	S335-S335
Number of pages	1
Journal	American Journal of Obstetrics Gynecology
Volume	206
Issue number	Supplement
DOIs	https://doi.org/10.1016/j.ajog.2011.10.775
State	Published - Jan 2012

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Twina, G., Lewis, E. C., Shahaf, G., Salem, S. Y., Madar, T., Baron, J., Wiznitzer, A., Mazor, M., Holcberg, G., & Sheiner, E. (2012). Low Levels and Activity of Circulating Alpha-1 Antitrypsin are a Possible Cause for Severe Preeclampsia. American Journal of Obstetrics Gynecology, 206(Supplement), S335-S335. Article abstract 757. https://doi.org/10.1016/j.ajog.2011.10.775

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title = "Low Levels and Activity of Circulating Alpha-1 Antitrypsin are a Possible Cause for Severe Preeclampsia",

abstract = "Alpha-1 antitrypsin (AAT) inhibits a wide variety of proteases and possesses anti-inflammatory and tissue-protective properties. During normal pregnancy, circulating AAT rises towards the third trimester. AAT was previously linked to placental and pregnancy complications. Preeclampsia is a multisystem pregnancy disorder of unknown cause. An immunological insight into the origin of preeclampsia was previously suggested. The purpose of the present prospective study was to examine whether low plasma concentration and activity of AAT might correlate with severe preeclampsia.",

author = "Guy Twina and Lewis, {Eli C} and Galit Shahaf and Salem, {Shimrit Yaniv} and Tamar Madar and Joel Baron and Arnon Wiznitzer and Moshe Mazor and Gershon Holcberg and Eyal Sheiner",

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doi = "10.1016/j.ajog.2011.10.775",

language = "English",

volume = "206",

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T1 - Low Levels and Activity of Circulating Alpha-1 Antitrypsin are a Possible Cause for Severe Preeclampsia

AU - Twina, Guy

AU - Lewis, Eli C

AU - Shahaf, Galit

AU - Salem, Shimrit Yaniv

AU - Madar, Tamar

AU - Baron, Joel

AU - Wiznitzer, Arnon

AU - Mazor, Moshe

AU - Holcberg, Gershon

AU - Sheiner, Eyal

PY - 2012/1

Y1 - 2012/1

N2 - Alpha-1 antitrypsin (AAT) inhibits a wide variety of proteases and possesses anti-inflammatory and tissue-protective properties. During normal pregnancy, circulating AAT rises towards the third trimester. AAT was previously linked to placental and pregnancy complications. Preeclampsia is a multisystem pregnancy disorder of unknown cause. An immunological insight into the origin of preeclampsia was previously suggested. The purpose of the present prospective study was to examine whether low plasma concentration and activity of AAT might correlate with severe preeclampsia.

AB - Alpha-1 antitrypsin (AAT) inhibits a wide variety of proteases and possesses anti-inflammatory and tissue-protective properties. During normal pregnancy, circulating AAT rises towards the third trimester. AAT was previously linked to placental and pregnancy complications. Preeclampsia is a multisystem pregnancy disorder of unknown cause. An immunological insight into the origin of preeclampsia was previously suggested. The purpose of the present prospective study was to examine whether low plasma concentration and activity of AAT might correlate with severe preeclampsia.

U2 - 10.1016/j.ajog.2011.10.775

DO - 10.1016/j.ajog.2011.10.775

M3 - Meeting Abstract

SN - 1097-6868

SN - 2589-9333

VL - 206

SP - S335-S335

JO - American Journal of Obstetrics Gynecology

JF - American Journal of Obstetrics Gynecology

IS - Supplement

M1 - abstract 757

ER -

Low Levels and Activity of Circulating Alpha-1 Antitrypsin are a Possible Cause for Severe Preeclampsia

Abstract

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