A 23187-stimulated calcium uptake and GABA release by cerebrocortical synaptosomes: effects of high pressure

S. C. Gilman, J. S. Colton, Y. Grossman

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Guinea pig cerebrocortical synaptosome preparations were used to study the effect of compression to 62 ATA on45Ca2+ uptake and [3H]GABA release using a calcium ionophore A23187, which bypasses the voltage-sensitive calcium channel. Pressure was found to exert a suppressive effect on the A 23187-induced release of [3H]GABA, while having no significant effect on A 23187-stimulated45Ca2+ uptake. On the other hand, both depolarization-induced45Ca2+ uptake and [3H]GABA release were inhibited by pressure exposure. These results suggest that pressure may suppress GABA release by affecting pre-synaptic events subsequent to calcium influx.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalJournal of Neural Transmission
Volume86
Issue number1
DOIs
StatePublished - 1 Feb 1991
Externally publishedYes

Keywords

  • A23187
  • GABA release
  • HPNS
  • Pressure
  • ionophore

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

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