Abstract
Guinea pig cerebrocortical synaptosome preparations were used to study the effect of compression to 62 ATA on45Ca2+ uptake and [3H]GABA release using a calcium ionophore A23187, which bypasses the voltage-sensitive calcium channel. Pressure was found to exert a suppressive effect on the A 23187-induced release of [3H]GABA, while having no significant effect on A 23187-stimulated45Ca2+ uptake. On the other hand, both depolarization-induced45Ca2+ uptake and [3H]GABA release were inhibited by pressure exposure. These results suggest that pressure may suppress GABA release by affecting pre-synaptic events subsequent to calcium influx.
Original language | English |
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Pages (from-to) | 1-9 |
Number of pages | 9 |
Journal | Journal of Neural Transmission |
Volume | 86 |
Issue number | 1 |
DOIs | |
State | Published - 1 Feb 1991 |
Externally published | Yes |
Keywords
- A23187
- GABA release
- HPNS
- Pressure
- ionophore
ASJC Scopus subject areas
- Neurology
- Clinical Neurology
- Psychiatry and Mental health
- Biological Psychiatry