A 23187-stimulated calcium uptake and GABA release by cerebrocortical synaptosomes: effects of high pressure

S. C. Gilman; J. S. Colton; Y. Grossman

doi:10.1007/BF01250371

A 23187-stimulated calcium uptake and GABA release by cerebrocortical synaptosomes: effects of high pressure

S. C. Gilman
, J. S. Colton
, Y. Grossman

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Guinea pig cerebrocortical synaptosome preparations were used to study the effect of compression to 62 ATA on⁴⁵Ca²⁺ uptake and [³H]GABA release using a calcium ionophore A23187, which bypasses the voltage-sensitive calcium channel. Pressure was found to exert a suppressive effect on the A 23187-induced release of [³H]GABA, while having no significant effect on A 23187-stimulated⁴⁵Ca²⁺ uptake. On the other hand, both depolarization-induced⁴⁵Ca²⁺ uptake and [³H]GABA release were inhibited by pressure exposure. These results suggest that pressure may suppress GABA release by affecting pre-synaptic events subsequent to calcium influx.

Original language	English
Pages (from-to)	1-9
Number of pages	9
Journal	Journal of Neural Transmission
Volume	86
Issue number	1
DOIs	https://doi.org/10.1007/BF01250371
State	Published - 1 Feb 1991
Externally published	Yes

Keywords

A23187
GABA release
HPNS
ionophore
Pressure

ASJC Scopus subject areas

Neurology
Clinical Neurology
Psychiatry and Mental health
Biological Psychiatry

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10.1007/BF01250371

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AU - Grossman, Y.

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A 23187-stimulated calcium uptake and GABA release by cerebrocortical synaptosomes: effects of high pressure

Abstract

Keywords

ASJC Scopus subject areas

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