A chiral pool based synthesis of platensimycin

K. C. Nicolaou, Doron Pappo, Kit Y. Tsang, Romelo Gibe, David Y.K. Chen

Research output: Contribution to journalArticlepeer-review

89 Scopus citations

Abstract

(Chemical Equation Presented) Extensive pharming: An expedient entry into the tetracycle 2, a late-stage synthetic intermediate en route to the broad-spectrum antibiotic (-)-platensimycin (1) has been accomplished. The strategy involves a series of cyclizations starting from the inexpensive chiral pool starting material (R)-(-)-carvone.

Original languageEnglish
Pages (from-to)944-946
Number of pages3
JournalAngewandte Chemie - International Edition
Volume47
Issue number5
DOIs
StatePublished - 1 Feb 2008
Externally publishedYes

Keywords

  • Antibiotics
  • Natural products
  • Radicals
  • Synthesis design

ASJC Scopus subject areas

  • Catalysis
  • Chemistry (all)

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