A chiral pool based synthesis of platensimycin

K. C. Nicolaou; Doron Pappo; Kit Y. Tsang; Romelo Gibe; David Y.K. Chen

doi:10.1002/anie.200705080

A chiral pool based synthesis of platensimycin

K. C. Nicolaou, Doron Pappo, Kit Y. Tsang, Romelo Gibe, David Y.K. Chen

Research output: Contribution to journal › Article › peer-review

90 Scopus citations

Abstract

(Chemical Equation Presented) Extensive pharming: An expedient entry into the tetracycle 2, a late-stage synthetic intermediate en route to the broad-spectrum antibiotic (-)-platensimycin (1) has been accomplished. The strategy involves a series of cyclizations starting from the inexpensive chiral pool starting material (R)-(-)-carvone.

Original language	English
Pages (from-to)	944-946
Number of pages	3
Journal	Angewandte Chemie - International Edition
Volume	47
Issue number	5
DOIs	https://doi.org/10.1002/anie.200705080
State	Published - 1 Feb 2008
Externally published	Yes

Keywords

Antibiotics
Natural products
Radicals
Synthesis design

ASJC Scopus subject areas

Catalysis
General Chemistry

Access to Document

10.1002/anie.200705080

Cite this

@article{3448500a703a4227a796ca6168606e39,

title = "A chiral pool based synthesis of platensimycin",

abstract = "(Chemical Equation Presented) Extensive pharming: An expedient entry into the tetracycle 2, a late-stage synthetic intermediate en route to the broad-spectrum antibiotic (-)-platensimycin (1) has been accomplished. The strategy involves a series of cyclizations starting from the inexpensive chiral pool starting material (R)-(-)-carvone.",

keywords = "Antibiotics, Natural products, Radicals, Synthesis design",

author = "Nicolaou, {K. C.} and Doron Pappo and Tsang, {Kit Y.} and Romelo Gibe and Chen, {David Y.K.}",

year = "2008",

month = feb,

day = "1",

doi = "10.1002/anie.200705080",

language = "English",

volume = "47",

pages = "944--946",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "John Wiley and Sons Ltd",

number = "5",

}

TY - JOUR

T1 - A chiral pool based synthesis of platensimycin

AU - Nicolaou, K. C.

AU - Pappo, Doron

AU - Tsang, Kit Y.

AU - Gibe, Romelo

AU - Chen, David Y.K.

PY - 2008/2/1

Y1 - 2008/2/1

N2 - (Chemical Equation Presented) Extensive pharming: An expedient entry into the tetracycle 2, a late-stage synthetic intermediate en route to the broad-spectrum antibiotic (-)-platensimycin (1) has been accomplished. The strategy involves a series of cyclizations starting from the inexpensive chiral pool starting material (R)-(-)-carvone.

AB - (Chemical Equation Presented) Extensive pharming: An expedient entry into the tetracycle 2, a late-stage synthetic intermediate en route to the broad-spectrum antibiotic (-)-platensimycin (1) has been accomplished. The strategy involves a series of cyclizations starting from the inexpensive chiral pool starting material (R)-(-)-carvone.

KW - Antibiotics

KW - Natural products

KW - Radicals

KW - Synthesis design

UR - http://www.scopus.com/inward/record.url?scp=38549174642&partnerID=8YFLogxK

U2 - 10.1002/anie.200705080

DO - 10.1002/anie.200705080

M3 - Article

AN - SCOPUS:38549174642

SN - 1433-7851

VL - 47

SP - 944

EP - 946

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 5

ER -

A chiral pool based synthesis of platensimycin

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this