A chiral template-driven synthesis of a 3′-deoxy-3′-18F-fluorothymidine precursor

Papiya Dey, K. S. Ajish Kumar, Anubha Sharma, Subrata Chattopadhyay

Research output: Contribution to journalArticlepeer-review

Abstract

An asymmetric synthesis of a 3′-deoxy-3′-18F-fluorothymidine (18F-FLT) precursor has been developed wherein the deoxysugar moiety was synthesized using a novel Ga-mediated allylation of (R)-2,3-cyclohexylideneglyceraldehyde as the key step. The synthesis deviates significantly from the previous syntheses of the 18F-FLT precursors wherein the expensive starting material, thymidine was used.

Original languageEnglish
Pages (from-to)1457-1462
Number of pages6
JournalEuropean Journal of Medicinal Chemistry
Volume143
DOIs
StatePublished - 1 Jan 2018
Externally publishedYes

Keywords

  • Asymmetric synthesis
  • Chiral template
  • FLT
  • PET imaging agent

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

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