Abstract
An asymmetric synthesis of a 3′-deoxy-3′-18F-fluorothymidine (18F-FLT) precursor has been developed wherein the deoxysugar moiety was synthesized using a novel Ga-mediated allylation of (R)-2,3-cyclohexylideneglyceraldehyde as the key step. The synthesis deviates significantly from the previous syntheses of the 18F-FLT precursors wherein the expensive starting material, thymidine was used.
Original language | English |
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Pages (from-to) | 1457-1462 |
Number of pages | 6 |
Journal | European Journal of Medicinal Chemistry |
Volume | 143 |
DOIs | |
State | Published - 1 Jan 2018 |
Externally published | Yes |
Keywords
- Asymmetric synthesis
- Chiral template
- FLT
- PET imaging agent
ASJC Scopus subject areas
- Pharmacology
- Drug Discovery
- Organic Chemistry