Abstract
Although epilepsy afflicts numerous people worldwide, its dynamics are still controversial. Especially seizure termination is relatively unidentified. Here we suggest a coherent explanation to all stages of epilepsy, its genesis, seizure initiation and termination. We present biophysical features that could account for the phenomenon: all phases of epilepsy can be related to the brain's “waste disposal” systems. Although problems in the astrocytic system have already been suggested as a major player in this malfunction, the termination phase is not really understood. Here it is assumed to arise from a G-lymphatic clearance system. Our biophysical mechanism provides a coherent explanation of the phenomenon, offers support for the previously published mathematical model, and can shed light on the conflicting results encountered in norepinephrine measurements in epilepsy treatment.
Original language | English |
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Article number | 109384 |
Journal | Medical Hypotheses |
Volume | 133 |
DOIs | |
State | Published - 1 Dec 2019 |
Keywords
- Epilepsy stages
- G-lymphatic system
- Ictal termination by brain's waste disposal
ASJC Scopus subject areas
- General Medicine