A comparative analysis of major clinical outcomes with drug-eluting stents versus bare metal stents in male versus female patients

Ran Kornowski, Hana Vaknin-Assa, Abid Assali, Eli I. Lev, Avital Porter, Alexander Battler, Tamir Bental

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Aims: To conduct a risk-adjusted gender-based analysis of clinical outcomes following drug-eluting stent (DES) versus bare metal stent (BMS) implantation in patients with coronary artery disease. Methods and results: We compared risk-adjusted total mortality rate, myocardial infarction, and eventfree survival (defined as freedom from death, myocardial infarction and/or repeat revascularisation) in a consecutive cohort of 7,662 patients undergoing percutaneous coronary intervention at our institution, including 1,835 (25.4%) women. Follow-up was six months to 6.2 years (mean: 3.5 years; median: 3.6 years). The women were older than men and more likely to suffer from diabetes, hypertension or congestive heart failure. Smokers were more often men, and men were more likely to have had prior coronary bypass surgery compared to women. A DES was used in 39.9% of males and 39.5% of females. Both genders derived a significant long-term clinical benefit from DES compared to BMS; advantages were observed for mortality (men: HR=0.78, 95% CI: 0.64-0.96, p=0.016; women: HR=0.62, 95% CI: 0.45-0.85, p=0.003) and major adverse cardiac events (men: HR=0.73, 95% CI: 0.63-0.84, p<0.001; women: HR=0.76, 95% CI: 0.52-0.84, p=0.001). Among BMS-treated patients, women had worse cumulative clinical outcomes than men. DES eliminated the gender differences in cardiac prognosis. Conclusions: Our analysis indicated a profound prognostic advantage for DES versus BMS among both genders, though female patients appeared to derive the greatest benefit.

Original languageEnglish
Pages (from-to)1051-1059
Number of pages9
JournalEuroIntervention
Volume7
Issue number9
DOIs
StatePublished - 1 Jan 2012
Externally publishedYes

Keywords

  • Bare metal stent
  • Coronary artery disease
  • Drug-eluting stent

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint

Dive into the research topics of 'A comparative analysis of major clinical outcomes with drug-eluting stents versus bare metal stents in male versus female patients'. Together they form a unique fingerprint.

Cite this