A Comprehensive Review on Selective Catalytic Methods for Functionalization of Adamantane Scaffolds

Over the decades, conventional techniques have been reported for the direct conversion of a substantial framework of adamantyl C(sp³)-H/Br/COOH bonds to various C−C, C−N, and other C−X bonds enabled by various catalytic conditions and reagents. There are various simple and direct methods for converting adamantane tertiary and secondary C-(Sp³)-H/X/M bonds to quaternary/ tertiary carbon-carbon bonds that have been reported in previous years, which include methods such as catalytic approaches, cross-coupling reactions, C−H bond functionalization, radical reactions, organometallics, and dual catalysis, etc. The selective catalytic techniques published between 2010 and 2023 are covered in this article. These adamantane derivatives are broadly studied in various fields such as medicinal chemistry applications, drug development, supramolecular chemistry, material science, catalysts/ligands, and nanotechnologies.