A convenient method for the synthesis of α-silylacetic acids

Alex V. Shtelman; James Y. Becker

doi:10.1016/j.tetlet.2008.03.050

A convenient method for the synthesis of α-silylacetic acids

Alex V. Shtelman, James Y. Becker

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

A method is described for the preparation of α-silylacetic acids of the type R₃SiCH₂CO₂H by treating trimethylsilyl acetate with LDA followed by quenching with chlorosilanes.

Original language	English
Pages (from-to)	3101-3103
Number of pages	3
Journal	Tetrahedron Letters
Volume	49
Issue number	19
DOIs	https://doi.org/10.1016/j.tetlet.2008.03.050
State	Published - 5 May 2008

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2008.03.050

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title = "A convenient method for the synthesis of α-silylacetic acids",

abstract = "A method is described for the preparation of α-silylacetic acids of the type R3SiCH2CO2H by treating trimethylsilyl acetate with LDA followed by quenching with chlorosilanes.",

author = "Shtelman, {Alex V.} and Becker, {James Y.}",

note = "Funding Information: This research was supported (in part) by The Israel Science Foundation. ",

year = "2008",

month = may,

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doi = "10.1016/j.tetlet.2008.03.050",

language = "English",

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T1 - A convenient method for the synthesis of α-silylacetic acids

AU - Shtelman, Alex V.

AU - Becker, James Y.

N1 - Funding Information: This research was supported (in part) by The Israel Science Foundation.

PY - 2008/5/5

Y1 - 2008/5/5

N2 - A method is described for the preparation of α-silylacetic acids of the type R3SiCH2CO2H by treating trimethylsilyl acetate with LDA followed by quenching with chlorosilanes.

AB - A method is described for the preparation of α-silylacetic acids of the type R3SiCH2CO2H by treating trimethylsilyl acetate with LDA followed by quenching with chlorosilanes.

UR - http://www.scopus.com/inward/record.url?scp=41649087529&partnerID=8YFLogxK

U2 - 10.1016/j.tetlet.2008.03.050

DO - 10.1016/j.tetlet.2008.03.050

M3 - Article

AN - SCOPUS:41649087529

SN - 0040-4039

VL - 49

SP - 3101

EP - 3103

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 19

ER -

A convenient method for the synthesis of α-silylacetic acids

Abstract

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